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Article: Oral candidal infections and antimycotics

TitleOral candidal infections and antimycotics
Authors
KeywordsAntimycotics
Candida
Oral candidosis
Post-antifungal effect
Issue Date2000
PublisherInternational and American Associations for Dental Research. The Journal's web site is located at http://crobm.iadrjournals.org/
Citation
Critical Reviews In Oral Biology And Medicine, 2000, v. 11 n. 2, p. 172-198 How to Cite?
AbstractThe advent of the human immunodeficiency virus infection and the increasing prevalence of compromised individuals in the community due to modern therapeutic advances have resulted in a resurgence of opportunistic infections, including oral candidoses. One form of the latter presents classically as a white lesion of 'thrush' and is usually easily diagnosed and cured. Nonetheless, a minority of these lesions appears in new guises such as erythematous candidosis, thereby confounding the unwary clinician and complicating its management. Despite the availability of several effective antimycotics for the treatment of oral candidoses, failure of therapy is not uncommon due to the unique environment of the oral cavity, where the flushing effect of saliva and the cleansing action of the oral musculature tend to reduce the drug concentration to sub-therapeutic levels. This problem has been partly circumvented by the introduction of the triazole agents, which initially appeared to be highly effective. However, an alarming increase of organisms resistant to the triazoles has been reported recently. In this review, an overview of clinical manifestations of oral candidoses and recent advances in antimycotic therapy is given, together with newer concepts, such as the post-antifungal effect (PAFE) and its possible therapeutic implications.
Persistent Identifierhttp://hdl.handle.net/10722/53206
ISSN
2006 Impact Factor: 6.0
2007 SCImago Journal Rankings: 2.029
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEllepola, ANBen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2009-04-03T07:04:07Z-
dc.date.available2009-04-03T07:04:07Z-
dc.date.issued2000en_HK
dc.identifier.citationCritical Reviews In Oral Biology And Medicine, 2000, v. 11 n. 2, p. 172-198en_HK
dc.identifier.issn1045-4411en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53206-
dc.description.abstractThe advent of the human immunodeficiency virus infection and the increasing prevalence of compromised individuals in the community due to modern therapeutic advances have resulted in a resurgence of opportunistic infections, including oral candidoses. One form of the latter presents classically as a white lesion of 'thrush' and is usually easily diagnosed and cured. Nonetheless, a minority of these lesions appears in new guises such as erythematous candidosis, thereby confounding the unwary clinician and complicating its management. Despite the availability of several effective antimycotics for the treatment of oral candidoses, failure of therapy is not uncommon due to the unique environment of the oral cavity, where the flushing effect of saliva and the cleansing action of the oral musculature tend to reduce the drug concentration to sub-therapeutic levels. This problem has been partly circumvented by the introduction of the triazole agents, which initially appeared to be highly effective. However, an alarming increase of organisms resistant to the triazoles has been reported recently. In this review, an overview of clinical manifestations of oral candidoses and recent advances in antimycotic therapy is given, together with newer concepts, such as the post-antifungal effect (PAFE) and its possible therapeutic implications.en_HK
dc.languageengen_HK
dc.publisherInternational and American Associations for Dental Research. The Journal's web site is located at http://crobm.iadrjournals.org/en_HK
dc.relation.ispartofCritical Reviews in Oral Biology and Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAntimycoticsen_HK
dc.subjectCandidaen_HK
dc.subjectOral candidosisen_HK
dc.subjectPost-antifungal effecten_HK
dc.subject.meshAIDS-Related Opportunistic Infections - drug therapyen_HK
dc.subject.meshAmphotericin B - therapeutic useen_HK
dc.subject.meshAnti-Infective Agents, Local - therapeutic useen_HK
dc.subject.meshAntifungal Agents - administration & dosage - classification - therapeutic useen_HK
dc.subject.meshCandida - drug effectsen_HK
dc.subject.meshCandidiasis, Oral - classification - drug therapyen_HK
dc.subject.meshChlorhexidine - therapeutic useen_HK
dc.subject.meshClotrimazole - therapeutic useen_HK
dc.subject.meshDrug Resistance, Fungalen_HK
dc.subject.meshFluconazole - therapeutic useen_HK
dc.subject.meshFlucytosine - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunocompromised Hosten_HK
dc.subject.meshItraconazole - therapeutic useen_HK
dc.subject.meshKetoconazole - therapeutic useen_HK
dc.subject.meshMiconazole - therapeutic useen_HK
dc.subject.meshMouth - physiologyen_HK
dc.subject.meshNystatin - therapeutic useen_HK
dc.subject.meshOpportunistic Infections - drug therapyen_HK
dc.subject.meshSaliva - physiologyen_HK
dc.subject.meshTreatment Failureen_HK
dc.subject.meshTriazoles - administration & dosage - classification - therapeutic useen_HK
dc.titleOral candidal infections and antimycoticsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-4411&volume=11&issue=2&spage=172&epage=198&date=2000&atitle=Oral+Candidal+Infections+and+Antimycoticsen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid12002814-
dc.identifier.scopuseid_2-s2.0-0033909508en_HK
dc.identifier.hkuros51664-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033909508&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue2en_HK
dc.identifier.spage172en_HK
dc.identifier.epage198en_HK
dc.identifier.isiWOS:000087783900003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridEllepola, ANB=6604060863en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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