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Article: Selection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from southeast Asia

TitleSelection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from southeast Asia
Authors
Issue Date2004
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2004, v. 78 n. 13, p. 7131-7137 How to Cite?
AbstractThe geographically constrained distribution of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in southeast Asian populations suggests that both viral and host genetics may influence disease risk. Although susceptibility loci have been mapped within the human genome, the role of viral genetics in the focal distribution of NPC remains an enigma. Here we report a molecular phylogenetic analysis of an NPC-associated viral oncogene, LMP1, in a large panel of EBV isolates from southeast Asia and from Papua New Guinea, Africa, and Australia, regions of the world where NPC is and is not endemic, respectively. This analysis revealed that LMP1 sequences show a distinct geographic structure, indicating that the southeast Asian isolates have evolved as a lineage distinct from those of Papua New Guinea, African, and Australian isolates. Furthermore, a likelihood ratio test revealed that the C termini of the LMP1 sequences of the southeast Asian lineage are under significant positive selection pressure, particularly at some sites within the C-terminal activator regions. We also present evidence that although the N terminus and transmembrane region of LMP1 have undergone recombination, the C-terminal region of the gene has evolved without any history of recombination. Based on these observations, we speculate that selection pressure may be driving the LMP1 sequences in virus isolates from southeast Asia towards a more malignant phenotype, thereby influencing the endemic distribution of NPC in this region.
Persistent Identifierhttp://hdl.handle.net/10722/49423
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBurrows, JMen_HK
dc.contributor.authorBromham, Len_HK
dc.contributor.authorWoolfit, Men_HK
dc.contributor.authorPiganeau, Gen_HK
dc.contributor.authorTellam, Jen_HK
dc.contributor.authorConnolly, Gen_HK
dc.contributor.authorWebb, Nen_HK
dc.contributor.authorPoulsen, Len_HK
dc.contributor.authorCooper, Len_HK
dc.contributor.authorBurrows, SRen_HK
dc.contributor.authorMoss, DJen_HK
dc.contributor.authorHaryana, SMen_HK
dc.contributor.authorNg, Men_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorKhanna, Ren_HK
dc.date.accessioned2008-06-12T06:42:11Z-
dc.date.available2008-06-12T06:42:11Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Virology, 2004, v. 78 n. 13, p. 7131-7137en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49423-
dc.description.abstractThe geographically constrained distribution of Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) in southeast Asian populations suggests that both viral and host genetics may influence disease risk. Although susceptibility loci have been mapped within the human genome, the role of viral genetics in the focal distribution of NPC remains an enigma. Here we report a molecular phylogenetic analysis of an NPC-associated viral oncogene, LMP1, in a large panel of EBV isolates from southeast Asia and from Papua New Guinea, Africa, and Australia, regions of the world where NPC is and is not endemic, respectively. This analysis revealed that LMP1 sequences show a distinct geographic structure, indicating that the southeast Asian isolates have evolved as a lineage distinct from those of Papua New Guinea, African, and Australian isolates. Furthermore, a likelihood ratio test revealed that the C termini of the LMP1 sequences of the southeast Asian lineage are under significant positive selection pressure, particularly at some sites within the C-terminal activator regions. We also present evidence that although the N terminus and transmembrane region of LMP1 have undergone recombination, the C-terminal region of the gene has evolved without any history of recombination. Based on these observations, we speculate that selection pressure may be driving the LMP1 sequences in virus isolates from southeast Asia towards a more malignant phenotype, thereby influencing the endemic distribution of NPC in this region.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2004, v. 78 n. 13, p. 7131-7137en_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshHerpesvirus 4, Human - genetics - isolation & purificationen_HK
dc.subject.meshNasopharyngeal Neoplasms - virologyen_HK
dc.subject.meshSelection (Genetics)en_HK
dc.subject.meshViral Matrix Proteins - geneticsen_HK
dc.titleSelection pressure-driven evolution of the Epstein-Barr virus-encoded oncogene LMP1 in virus isolates from southeast Asiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=78&issue=13&spage=7131&epage=7137&date=2004&atitle=Selection+pressure-driven+evolution+of+the+Epstein-Barr+virus-encoded+oncogene+LMP1+in+virus+isolates+from+southeast+Asiaen_HK
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.78.13.7131-7137.2004en_HK
dc.identifier.pmid15194789-
dc.identifier.pmcidPMC421669en_HK
dc.identifier.scopuseid_2-s2.0-2942687018en_HK
dc.identifier.hkuros94890-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942687018&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue13en_HK
dc.identifier.spage7131en_HK
dc.identifier.epage7137en_HK
dc.identifier.isiWOS:000222153800045-
dc.publisher.placeUnited Statesen_HK

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