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Article: Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma: Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells

TitleExpression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma: Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells
Authors
Issue Date1995
PublisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org
Citation
American Journal Of Pathology, 1995, v. 147 n. 4, p. 1152-1160 How to Cite?
AbstractUndifferentiated nasopharyngeal carcinomas (UNPC) are characterized by an association with Epstein-Barr virus and an abundant lymphoid stroma. The role of this lymphoid stroma is uncertain but is mostly thought to represent an immune response against viral or tumor antigens. We have analyzed the expression of immune regulatory receptor/ligand pairs in snap-frozen biopsies of 20 UNPCs. All cases were Epstein-Barr virus positive and the virus- encoded latent membrane protein, LMP1, was expressed in 6 cases. By immunohistochemistry, we have demonstrated the expression of CD70 and CD40 in the tumor cells of 16 and 18 cases, respectively. Infiltrating lymphoid cells expressing CD27, the CD70 receptor, and the CD40 ligand were present in all cases. The Bcl-2 protein was detected in 17 cases. Unexpectedly, tumor cells of 5 cases expressed at least one member of the B7 family (CD80, CD86, and B7-3) and many lymphoid cells expressing the corresponding counter-receptor, CD28, were detected in all cases. Interestingly, 5 of 6 LMP1-positive cases also expressed B7, whereas all 14 LMP1-negative cases were also B7 negative. Our results indicate that T cells and carcinoma cells communicate in the microenvironment of UNPCs and suggest that the presence of a lymphoid stroma may be a requirement for UNPC growth at least in certain stages of tumor development.
Persistent Identifierhttp://hdl.handle.net/10722/49422
ISSN
2015 Impact Factor: 4.206
2015 SCImago Journal Rankings: 2.653
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAgathanggelou, Aen_HK
dc.contributor.authorNiedobitek, Gen_HK
dc.contributor.authorChen, Ren_HK
dc.contributor.authorNicholls, Jen_HK
dc.contributor.authorYin, Wen_HK
dc.contributor.authorYoung, LSen_HK
dc.date.accessioned2008-06-12T06:42:09Z-
dc.date.available2008-06-12T06:42:09Z-
dc.date.issued1995en_HK
dc.identifier.citationAmerican Journal Of Pathology, 1995, v. 147 n. 4, p. 1152-1160en_HK
dc.identifier.issn0002-9440en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49422-
dc.description.abstractUndifferentiated nasopharyngeal carcinomas (UNPC) are characterized by an association with Epstein-Barr virus and an abundant lymphoid stroma. The role of this lymphoid stroma is uncertain but is mostly thought to represent an immune response against viral or tumor antigens. We have analyzed the expression of immune regulatory receptor/ligand pairs in snap-frozen biopsies of 20 UNPCs. All cases were Epstein-Barr virus positive and the virus- encoded latent membrane protein, LMP1, was expressed in 6 cases. By immunohistochemistry, we have demonstrated the expression of CD70 and CD40 in the tumor cells of 16 and 18 cases, respectively. Infiltrating lymphoid cells expressing CD27, the CD70 receptor, and the CD40 ligand were present in all cases. The Bcl-2 protein was detected in 17 cases. Unexpectedly, tumor cells of 5 cases expressed at least one member of the B7 family (CD80, CD86, and B7-3) and many lymphoid cells expressing the corresponding counter-receptor, CD28, were detected in all cases. Interestingly, 5 of 6 LMP1-positive cases also expressed B7, whereas all 14 LMP1-negative cases were also B7 negative. Our results indicate that T cells and carcinoma cells communicate in the microenvironment of UNPCs and suggest that the presence of a lymphoid stroma may be a requirement for UNPC growth at least in certain stages of tumor development.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.orgen_HK
dc.relation.ispartofAmerican Journal of Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma - pathology - virologyen_HK
dc.subject.meshHerpesvirus 4, human - isolation & purificationen_HK
dc.subject.meshImmune system - physiologyen_HK
dc.subject.meshLymphoid tissue - pathology - physiopathologyen_HK
dc.subject.meshNasopharyngeal neoplasms - pathology - virologyen_HK
dc.titleExpression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma: Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cellsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9440&volume=147&issue=4&spage=1152&epage=1160&date=1995&atitle=Expression+of+immune+regulatory+molecules+in+Epstein-Barr+virus-associated+nasopharyngeal+carcinomas+with+prominent+lymphoid+stroma:+evidence+for+a+functional+interaction+between+epithelial+tumor+cells+and+infiltrating+lymphoid+cellsen_HK
dc.identifier.emailNicholls, J:nicholls@pathology.hku.hken_HK
dc.identifier.authorityNicholls, J=rp00364en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid7573360-
dc.identifier.pmcidPMC1871000-
dc.identifier.scopuseid_2-s2.0-0028783879en_HK
dc.identifier.hkuros8738-
dc.identifier.volume147en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1152en_HK
dc.identifier.epage1160en_HK
dc.identifier.isiWOS:A1995RZ18200028-
dc.publisher.placeUnited Statesen_HK

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