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Article: MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes

TitleMLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes
Authors
Issue Date1997
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1997, v. 57 n. 1, p. 117-122 How to Cite?
AbstractFifty-six patients with de novo acute myeloid leukemia M4/M5 subtypes were studied for rearrangements of the mixed lineage leukemia gene, MLL (also called HRX, Htrx-1, or ALL-1). Ten patients (18%) showed rearrangements of the MLL gene, 9 in a major breakpoint cluster region within a centromeric 8.3-kb BamHI fragment, whereas rearrangement in one patient was the result of a direct tandem duplication of exons 2-6 of MLL. Analysis of sequences at the duplication junction revealed that the points of MLL fusion within introns 6 and 1 both lie within Alu elements. This suggests the involvement of Alu repeat mediated homologous recombination in MLL self fusion. For the 10 rearranged samples, cytogenetics analysis revealed a normal karyotype in 3, and 3 had abnormalities other than 11q23. Survival analysis of patients revealed no difference between those with rearrangement of MLL and those showing the germ-line configuration.
Persistent Identifierhttp://hdl.handle.net/10722/49408
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, CWen_HK
dc.contributor.authorMa, ZGen_HK
dc.contributor.authorPrice, CMen_HK
dc.contributor.authorDong, Sen_HK
dc.contributor.authorChen, SJen_HK
dc.contributor.authorGu, LJen_HK
dc.contributor.authorSo, CKCen_HK
dc.contributor.authorWiedemann, LMen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2008-06-12T06:41:50Z-
dc.date.available2008-06-12T06:41:50Z-
dc.date.issued1997en_HK
dc.identifier.citationCancer Research, 1997, v. 57 n. 1, p. 117-122en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49408-
dc.description.abstractFifty-six patients with de novo acute myeloid leukemia M4/M5 subtypes were studied for rearrangements of the mixed lineage leukemia gene, MLL (also called HRX, Htrx-1, or ALL-1). Ten patients (18%) showed rearrangements of the MLL gene, 9 in a major breakpoint cluster region within a centromeric 8.3-kb BamHI fragment, whereas rearrangement in one patient was the result of a direct tandem duplication of exons 2-6 of MLL. Analysis of sequences at the duplication junction revealed that the points of MLL fusion within introns 6 and 1 both lie within Alu elements. This suggests the involvement of Alu repeat mediated homologous recombination in MLL self fusion. For the 10 rearranged samples, cytogenetics analysis revealed a normal karyotype in 3, and 3 had abnormalities other than 11q23. Survival analysis of patients revealed no difference between those with rearrangement of MLL and those showing the germ-line configuration.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshChromosomes, Human, Pair 11 - geneticsen_HK
dc.subject.meshGene Rearrangementen_HK
dc.subject.meshLeukemia, Monocytic, Acute - geneticsen_HK
dc.subject.meshLeukemia, Myelomonocytic, Acute - geneticsen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.titleMLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=57&issue=1&spage=117&epage=122&date=1997&atitle=MLL+self+fusion+mediated+by+Alu+repeat+homologous+recombination+and+prognosis+of+AML-M4/M5+subtypesen_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8988051-
dc.identifier.scopuseid_2-s2.0-0031016620en_HK
dc.identifier.hkuros26179-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031016620&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue1en_HK
dc.identifier.spage117en_HK
dc.identifier.epage122en_HK
dc.identifier.isiWOS:A1997WA69100024-
dc.publisher.placeUnited Statesen_HK

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