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Article: Loss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand

TitleLoss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular ligand
Authors
Issue Date1998
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
National Academy of Sciences Proceedings, 1998, v. 95 n. 2, p. 576-581 How to Cite?
AbstractThe erythropoietin-producing hepatocellular (Eph) family of ligands and receptors has been implicated in the control of axon guidance and the segmental restriction of cells during embryonic development. In this report, we show that ectopic expression of XLerk, a Xenopus homologue of the murine Lerk-2 (ephrin-B1) transmembrane ligand, causes dissociation of Xenopus embryonic blastomeres by the mid-blastula transition. Moreover, a mutant that lacks the extracellular receptor binding domain can induce this phenotype. The carboxyl-terminal 19 amino acids of the cytoplasmic domain of XLerk are necessary but not sufficient to induce cellular dissociation. Basic fibroblast growth factor, but not activin, can rescue both the loss of cell adhesion and mesoderm induction in ectodermal explants expressing XLerk. Collectively, these results show that the cytoplasmic domain of XLerk has a signaling function that is important for cell adhesion, and fibroblast growth factor signaling modulates this function.
Persistent Identifierhttp://hdl.handle.net/10722/49401
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJones, TLen_HK
dc.contributor.authorChong, LDen_HK
dc.contributor.authorKim, Jen_HK
dc.contributor.authorXu, RHen_HK
dc.contributor.authorKung, Hen_HK
dc.contributor.authorDaar, IOen_HK
dc.date.accessioned2008-06-12T06:41:35Z-
dc.date.available2008-06-12T06:41:35Z-
dc.date.issued1998en_HK
dc.identifier.citationNational Academy of Sciences Proceedings, 1998, v. 95 n. 2, p. 576-581en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49401-
dc.description.abstractThe erythropoietin-producing hepatocellular (Eph) family of ligands and receptors has been implicated in the control of axon guidance and the segmental restriction of cells during embryonic development. In this report, we show that ectopic expression of XLerk, a Xenopus homologue of the murine Lerk-2 (ephrin-B1) transmembrane ligand, causes dissociation of Xenopus embryonic blastomeres by the mid-blastula transition. Moreover, a mutant that lacks the extracellular receptor binding domain can induce this phenotype. The carboxyl-terminal 19 amino acids of the cytoplasmic domain of XLerk are necessary but not sufficient to induce cellular dissociation. Basic fibroblast growth factor, but not activin, can rescue both the loss of cell adhesion and mesoderm induction in ectodermal explants expressing XLerk. Collectively, these results show that the cytoplasmic domain of XLerk has a signaling function that is important for cell adhesion, and fibroblast growth factor signaling modulates this function.en_HK
dc.format.extent384 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsNational Academy of Sciences Proceedings. Copyright © National Academy of Sciences.en_HK
dc.subject.meshMembrane Glycoproteins - physiologyen_HK
dc.subject.meshXenopus Proteinsen_HK
dc.subject.meshXenopus laevis - embryology - physiologyen_HK
dc.subject.meshCell Adhesion - physiologyen_HK
dc.subject.meshErythropoietin - physiologyen_HK
dc.titleLoss of cell adhesion in Xenopus laevis embryos mediated by the cytoplasmic domain of XLerk, an erythropoietin-producing hepatocellular liganden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=95&issue=2&spage=576&epage=581&date=1998&atitle=Loss+of+cell+adhesion+in+Xenopus+laevis+embryos+mediated+by+the+cytoplasmic+domain+of+XLerk,+an+erythropoietin-producing+hepatocellular+liganden_HK
dc.identifier.emailKung, H: hkung@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1073/pnas.95.2.576-
dc.identifier.pmid9435234en_HK
dc.identifier.pmcidPMC18462en_HK
dc.identifier.scopuseid_2-s2.0-0031906668-
dc.identifier.hkuros46298-
dc.identifier.isiWOS:000071606000027-

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