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Article: Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene

TitleIdentification and characterization of multiple osmotic response sequences in the human aldose reductase gene
Authors
Issue Date1997
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 1997, v. 272 n. 26, p. 16431-16437 How to Cite?
AbstractAldose reductase (AR) has been implicated in osmoregulation in the kidney because it reduces glucose to sorbitol, which can serve as an osmolite. Under hyperosmotic stress, transcription of this gene is induced to increase the enzyme level. This mode of osmotic regulation of AR gene expression has been observed in a number of nonrenal cells as well, suggesting that this is a common response to hyperosmotic stress. We have identified a 132-base pair sequence 1 kilobase pairs upstream of the transcription start site of the AR gene that enhances the transcription activity of the AR promoter as well as that of the SV40 promoter when the cells are under hyperosmotic stress. Within this 132-base pair sequence, there are three sequences that resemble TonE, the tonicity response element of the canine betaine transporter gene, and the osmotic response element of the rabbit AR gene, suggesting that the mechanism of osmotic regulation of gene expression in these animals is similar. However, our data indicate that cooperative interaction among the three TonE-like sequences in the human AR may be necessary for their enhancer function.
Persistent Identifierhttp://hdl.handle.net/10722/49397
ISSN
2015 Impact Factor: 4.258
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKo, BCBen_HK
dc.contributor.authorRuepp, Ben_HK
dc.contributor.authorBohren, KMen_HK
dc.contributor.authorGabbay, KHen_HK
dc.contributor.authorChung, SSMen_HK
dc.date.accessioned2008-06-12T06:41:29Z-
dc.date.available2008-06-12T06:41:29Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of Biological Chemistry, 1997, v. 272 n. 26, p. 16431-16437en_HK
dc.identifier.issn0021-9258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49397-
dc.description.abstractAldose reductase (AR) has been implicated in osmoregulation in the kidney because it reduces glucose to sorbitol, which can serve as an osmolite. Under hyperosmotic stress, transcription of this gene is induced to increase the enzyme level. This mode of osmotic regulation of AR gene expression has been observed in a number of nonrenal cells as well, suggesting that this is a common response to hyperosmotic stress. We have identified a 132-base pair sequence 1 kilobase pairs upstream of the transcription start site of the AR gene that enhances the transcription activity of the AR promoter as well as that of the SV40 promoter when the cells are under hyperosmotic stress. Within this 132-base pair sequence, there are three sequences that resemble TonE, the tonicity response element of the canine betaine transporter gene, and the osmotic response element of the rabbit AR gene, suggesting that the mechanism of osmotic regulation of gene expression in these animals is similar. However, our data indicate that cooperative interaction among the three TonE-like sequences in the human AR may be necessary for their enhancer function.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_HK
dc.relation.ispartofJournal of Biological Chemistryen_HK
dc.rightsJournal of Biological Chemistry. Copyright © American Society for Biochemistry and Molecular Biology, Inc.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAldehyde Reductase - chemistry - geneticsen_HK
dc.subject.meshGene Expression Regulation, Enzymologicen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshOpen Reading Framesen_HK
dc.subject.meshOsmolar Concentrationen_HK
dc.titleIdentification and characterization of multiple osmotic response sequences in the human aldose reductase geneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9258&volume=272&issue=26&spage=16431&epage=16437&date=1997&atitle=Identification+and+characterization+of+multiple+osmotic+response+sequences+in+the+human+aldose+reductase+geneen_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.authorityChung, SSM=rp00376en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1074/jbc.272.26.16431en_HK
dc.identifier.pmid9195951-
dc.identifier.scopuseid_2-s2.0-0030908643en_HK
dc.identifier.hkuros26393-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030908643&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume272en_HK
dc.identifier.issue26en_HK
dc.identifier.spage16431en_HK
dc.identifier.epage16437en_HK
dc.identifier.isiWOS:A1997XG01900055-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKo, BCB=7102833927en_HK
dc.identifier.scopusauthoridRuepp, B=6507278925en_HK
dc.identifier.scopusauthoridBohren, KM=7004003248en_HK
dc.identifier.scopusauthoridGabbay, KH=7005782145en_HK
dc.identifier.scopusauthoridChung, SSM=14120761600en_HK

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