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Article: Analysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: Relation to puberty

TitleAnalysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: Relation to puberty
Authors
Issue Date1994
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 1994, v. 78 n. 5, p. 1195-1201 How to Cite?
AbstractTo evaluate the developmental and sex-specific changes in spontaneous GH secretion in terms of both secretory rate and pulsatile pattern, we investigated 24-h GH profiles (integrated 20-min samples) in 208 healthy children (91 girls and 117 boys) of normal heights at all stages of puberty. The plasma GH concentrations were transformed to GH secretion rates by means of a deconvolution technique. In prepubertal boys and girls, the mean secretion rates were comparable (0.66 and 0.68 U/24 h), but increased during puberty differently: earlier in girls, already at stage 2, with the highest rates at stages 3 and 4 (1.70 and 1.96 U/24 h); later in boys, at stage 4 (1.66 U/24 h). In both sexes the GH secretion rate decreased to prepubertal values at stage 5. The GH secretion rate correlated negatively with weight for height expressed in SD scores only in puberty (boys, r = -.044, P < 0.001; girls, r = -0.22; P < 0.05). The number of peaks with high amplitudes increased with the progress of puberty in both boys (stage 2) and girls (stages 3 and 4). In both prepubertal girls and boys, a marked day-night rhythm was observed, which disappeared in midpuberty in boys owing to a greater increase in peak amplitudes during the day than at night. The mean number of peaks per 24 h was unchanged in girls, but decreased in late pubertal boys. In summary, we found a sex-specific increase in the GH secretion rate during pubertal development that occurs at an earlier pubertal stage and is more pronounced in girls than in boys. There are underlying changes in the mean GH amplitudes in both boys and girls as well as an increased baseline secretion in girls. In puberty, body composition modulates the GH secretion rate in both sexes.
Persistent Identifierhttp://hdl.handle.net/10722/49393
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAlbertssonWikland, Ken_HK
dc.contributor.authorRosberg, Sen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorGroth, Ten_HK
dc.date.accessioned2008-06-12T06:41:19Z-
dc.date.available2008-06-12T06:41:19Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 1994, v. 78 n. 5, p. 1195-1201en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49393-
dc.description.abstractTo evaluate the developmental and sex-specific changes in spontaneous GH secretion in terms of both secretory rate and pulsatile pattern, we investigated 24-h GH profiles (integrated 20-min samples) in 208 healthy children (91 girls and 117 boys) of normal heights at all stages of puberty. The plasma GH concentrations were transformed to GH secretion rates by means of a deconvolution technique. In prepubertal boys and girls, the mean secretion rates were comparable (0.66 and 0.68 U/24 h), but increased during puberty differently: earlier in girls, already at stage 2, with the highest rates at stages 3 and 4 (1.70 and 1.96 U/24 h); later in boys, at stage 4 (1.66 U/24 h). In both sexes the GH secretion rate decreased to prepubertal values at stage 5. The GH secretion rate correlated negatively with weight for height expressed in SD scores only in puberty (boys, r = -.044, P < 0.001; girls, r = -0.22; P < 0.05). The number of peaks with high amplitudes increased with the progress of puberty in both boys (stage 2) and girls (stages 3 and 4). In both prepubertal girls and boys, a marked day-night rhythm was observed, which disappeared in midpuberty in boys owing to a greater increase in peak amplitudes during the day than at night. The mean number of peaks per 24 h was unchanged in girls, but decreased in late pubertal boys. In summary, we found a sex-specific increase in the GH secretion rate during pubertal development that occurs at an earlier pubertal stage and is more pronounced in girls than in boys. There are underlying changes in the mean GH amplitudes in both boys and girls as well as an increased baseline secretion in girls. In puberty, body composition modulates the GH secretion rate in both sexes.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Endocrinology and Metabolism. Copyright © The Endocrine Society.en_HK
dc.subject.meshGrowth hormone - blood - secretionen_HK
dc.subject.meshPuberty - blooden_HK
dc.subject.meshSex factorsen_HK
dc.subject.meshTime factorsen_HK
dc.titleAnalysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: Relation to pubertyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=78&issue=5&spage=1195&epage=1201&date=1994&atitle=Analysis+of+24-hour+growth+hormone+profiles+in+healthy+boys+and+girls+of+normal+stature:+relation+to+pubertyen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1210/jc.78.5.1195en_HK
dc.identifier.pmid8175978en_HK
dc.identifier.scopuseid_2-s2.0-0028288736en_HK
dc.identifier.hkuros2917-
dc.identifier.volume78en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1195en_HK
dc.identifier.epage1201en_HK
dc.identifier.isiWOS:A1994NK24100036-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAlbertssonWikland, K=19639814800en_HK
dc.identifier.scopusauthoridRosberg, S=7003930898en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridGroth, T=7006645964en_HK

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