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Article: Prevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat
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TitlePrevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat
 
AuthorsHui, SC
Sevilla, EL2
Ogle, CW1
 
KeywordsOndansetron
Cyproheptadine
Morphine dependence
Morphine tolerance
 
Issue Date1996
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjp
 
CitationBritish Journal of Pharmacology, 1996, v. 118 n. 4, p. 1044-1050 [How to Cite?]
 
Abstract1. The effect of ondansetron, a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, was studied in morphine-addicted rats. Morphine-dependence and tolerance, induced by drinking increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks, were demonstrated by the naloxone-precipitated withdrawal syndrome and tail flick response to a thermal noxious stimulus (water at 50 degrees C), respectively. 2. Morphine-dependence, assessed by naloxone precipitated withdrawal, was undetectable by the 6th day, when the animals drank only tap water for 7 days after the 3-week induction period. 3. When detoxified rats were offered sucrose and morphine solutions for 10 days, the recurrence of opiate solution preference with relapse to dependence and tolerance was observed. 4. Giving ondansetron (0.1 or 1 microgram kg-1; i.p.; twice daily) on the 14th day of, or 7 days prior to, the 3-week induction period reduced dependence and tolerance seen during the 3-week morphine induction and the 10-day drinking preference periods. 5. 5-Hydroxytryptamine2 (5-HT2) receptor antagonism by cyproheptadine (100 or 250 micrograms kg-1; i.p.; twice daily) did not influence morphine-dependence and tolerance. 6. These findings suggest that ondansetron may be useful for treating opiate addiction and lowering the recidivism rate.
 
ISSN0007-1188
2012 Impact Factor: 5.067
2012 SCImago Journal Rankings: 1.488
 
PubMed Central IDPMC1909532
 
ISI Accession Number IDWOS:A1996UT59300031
 
DC FieldValue
dc.contributor.authorHui, SC
 
dc.contributor.authorSevilla, EL
 
dc.contributor.authorOgle, CW
 
dc.date.accessioned2008-06-12T06:41:13Z
 
dc.date.available2008-06-12T06:41:13Z
 
dc.date.issued1996
 
dc.description.abstract1. The effect of ondansetron, a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, was studied in morphine-addicted rats. Morphine-dependence and tolerance, induced by drinking increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks, were demonstrated by the naloxone-precipitated withdrawal syndrome and tail flick response to a thermal noxious stimulus (water at 50 degrees C), respectively. 2. Morphine-dependence, assessed by naloxone precipitated withdrawal, was undetectable by the 6th day, when the animals drank only tap water for 7 days after the 3-week induction period. 3. When detoxified rats were offered sucrose and morphine solutions for 10 days, the recurrence of opiate solution preference with relapse to dependence and tolerance was observed. 4. Giving ondansetron (0.1 or 1 microgram kg-1; i.p.; twice daily) on the 14th day of, or 7 days prior to, the 3-week induction period reduced dependence and tolerance seen during the 3-week morphine induction and the 10-day drinking preference periods. 5. 5-Hydroxytryptamine2 (5-HT2) receptor antagonism by cyproheptadine (100 or 250 micrograms kg-1; i.p.; twice daily) did not influence morphine-dependence and tolerance. 6. These findings suggest that ondansetron may be useful for treating opiate addiction and lowering the recidivism rate.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent418 bytes
 
dc.format.mimetypetext/html
 
dc.identifier.citationBritish Journal of Pharmacology, 1996, v. 118 n. 4, p. 1044-1050 [How to Cite?]
 
dc.identifier.hkuros20187
 
dc.identifier.isiWOS:A1996UT59300031
 
dc.identifier.issn0007-1188
2012 Impact Factor: 5.067
2012 SCImago Journal Rankings: 1.488
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1909532
 
dc.identifier.pmid8799580
 
dc.identifier.scopuseid_2-s2.0-0029658979
 
dc.identifier.urihttp://hdl.handle.net/10722/49391
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjp
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectOndansetron
 
dc.subjectCyproheptadine
 
dc.subjectMorphine dependence
 
dc.subjectMorphine tolerance
 
dc.titlePrevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Cebu Institute of Medicine