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Article: Prevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat

TitlePrevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat
Authors
KeywordsOndansetron
Cyproheptadine
Morphine dependence
Morphine tolerance
Issue Date1996
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjp
Citation
British Journal of Pharmacology, 1996, v. 118 n. 4, p. 1044-1050 How to Cite?
Abstract1. The effect of ondansetron, a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, was studied in morphine-addicted rats. Morphine-dependence and tolerance, induced by drinking increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks, were demonstrated by the naloxone-precipitated withdrawal syndrome and tail flick response to a thermal noxious stimulus (water at 50 degrees C), respectively. 2. Morphine-dependence, assessed by naloxone precipitated withdrawal, was undetectable by the 6th day, when the animals drank only tap water for 7 days after the 3-week induction period. 3. When detoxified rats were offered sucrose and morphine solutions for 10 days, the recurrence of opiate solution preference with relapse to dependence and tolerance was observed. 4. Giving ondansetron (0.1 or 1 microgram kg-1; i.p.; twice daily) on the 14th day of, or 7 days prior to, the 3-week induction period reduced dependence and tolerance seen during the 3-week morphine induction and the 10-day drinking preference periods. 5. 5-Hydroxytryptamine2 (5-HT2) receptor antagonism by cyproheptadine (100 or 250 micrograms kg-1; i.p.; twice daily) did not influence morphine-dependence and tolerance. 6. These findings suggest that ondansetron may be useful for treating opiate addiction and lowering the recidivism rate.
Persistent Identifierhttp://hdl.handle.net/10722/49391
ISSN
2014 Impact Factor: 4.842
2013 SCImago Journal Rankings: 2.253
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHui, SCen_HK
dc.contributor.authorSevilla, ELen_HK
dc.contributor.authorOgle, CWen_HK
dc.date.accessioned2008-06-12T06:41:13Z-
dc.date.available2008-06-12T06:41:13Z-
dc.date.issued1996en_HK
dc.identifier.citationBritish Journal of Pharmacology, 1996, v. 118 n. 4, p. 1044-1050en_HK
dc.identifier.issn0007-1188en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49391-
dc.description.abstract1. The effect of ondansetron, a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, was studied in morphine-addicted rats. Morphine-dependence and tolerance, induced by drinking increasing concentrations of morphine sulphate in 5% sucrose solution for 3 weeks, were demonstrated by the naloxone-precipitated withdrawal syndrome and tail flick response to a thermal noxious stimulus (water at 50 degrees C), respectively. 2. Morphine-dependence, assessed by naloxone precipitated withdrawal, was undetectable by the 6th day, when the animals drank only tap water for 7 days after the 3-week induction period. 3. When detoxified rats were offered sucrose and morphine solutions for 10 days, the recurrence of opiate solution preference with relapse to dependence and tolerance was observed. 4. Giving ondansetron (0.1 or 1 microgram kg-1; i.p.; twice daily) on the 14th day of, or 7 days prior to, the 3-week induction period reduced dependence and tolerance seen during the 3-week morphine induction and the 10-day drinking preference periods. 5. 5-Hydroxytryptamine2 (5-HT2) receptor antagonism by cyproheptadine (100 or 250 micrograms kg-1; i.p.; twice daily) did not influence morphine-dependence and tolerance. 6. These findings suggest that ondansetron may be useful for treating opiate addiction and lowering the recidivism rate.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjpen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectOndansetronen_HK
dc.subjectCyproheptadineen_HK
dc.subjectMorphine dependenceen_HK
dc.subjectMorphine toleranceen_HK
dc.titlePrevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1188&volume=118&issue=4&spage=1044&epage=1050&date=1996&atitle=Prevention+by+the+5-HT3+receptor+antagonist,+ondansetron,+of+morphine-dependence+and+tolerance+in+the+raten_HK
dc.identifier.emailHui, SC: schui@hkuspace.hku.hken_HK
dc.identifier.emailOgle, CW: cwogle@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8799580en_HK
dc.identifier.pmcidPMC1909532-
dc.identifier.scopuseid_2-s2.0-0029658979-
dc.identifier.hkuros20187-
dc.identifier.isiWOS:A1996UT59300031-

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