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Article: Oral misoprostol for cervical priming in non-pregnant women

TitleOral misoprostol for cervical priming in non-pregnant women
Authors
KeywordsCervical priming
Non-pregnant women
Oral misoprostol
Issue Date1997
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 1997, v. 12 n. 11, p. 2373-2375 How to Cite?
AbstractEndometrial biopsy and hysteroscopy are important investigations in women presenting with abnormal vaginal bleeding. Endometrial biopsy is often performed as an outpatient procedure by endometrial aspiration. Difficulty in entering the internal cervical os may be encountered, especially in nulliparous women. The same problem may occur during hysteroscopy or dilatation and curettage. It is well known that use of a cervical priming agent is effective in reducing complications during cervical dilatation in pregnant women. However, its use in non-pregnant women is not well established. We compared oral misoprostol versus placebo for a cervical priming effect in non-pregnant women prior to hysteroscopy. The cumulative force required for cervical dilatation was significantly lower whereas the baseline cervical dilatation was significantly greater in the misoprostol group. We conclude that oral misoprostol is effective for pre-operative cervical dilatation in non-pregnant women. | Difficulties with entering the internal cervical os in nonpregnant women (especially nulliparous women) can hinder performance of endometrial aspiration or hysteroscopy in patients presenting with abnormal vaginal bleeding. This study investigated the usefulness of oral misoprostol--shown to be effective in cervical dilatation in first and third trimester abortion--for preoperative cervical dilatation in non-pregnant women. 44 nulliparous women presenting to Hong Kong's Queen Mary Hospital for diagnostic hysteroscopy and endometrial biopsy and curettage were randomly assigned to receive either 400 mcg of misoprostol 12 hours prior to the procedure (n = 21) or placebo (n = 23). Pretreatment with misoprostol significantly reduced the amount of force required to dilate the cervix to 8 mm from 103.7 Newtons in controls to 40.0 Newtons in women treated with misoprostol. The mean baseline cervical dilatation was significantly greater in the misoprostol group (6.0 mm) than in controls (3.3 mm). There were no immediate intraoperative complications and all women were discharged within 12 hours of the procedure. Another potential use of misoprostol is for cervical dilatation prior to IUD insertion in nulliparous women.
Persistent Identifierhttp://hdl.handle.net/10722/49385
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNgai, SWen_HK
dc.contributor.authorChan, YMen_HK
dc.contributor.authorLiu, KLen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2008-06-12T06:41:04Z-
dc.date.available2008-06-12T06:41:04Z-
dc.date.issued1997en_HK
dc.identifier.citationHuman Reproduction, 1997, v. 12 n. 11, p. 2373-2375en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49385-
dc.description.abstractEndometrial biopsy and hysteroscopy are important investigations in women presenting with abnormal vaginal bleeding. Endometrial biopsy is often performed as an outpatient procedure by endometrial aspiration. Difficulty in entering the internal cervical os may be encountered, especially in nulliparous women. The same problem may occur during hysteroscopy or dilatation and curettage. It is well known that use of a cervical priming agent is effective in reducing complications during cervical dilatation in pregnant women. However, its use in non-pregnant women is not well established. We compared oral misoprostol versus placebo for a cervical priming effect in non-pregnant women prior to hysteroscopy. The cumulative force required for cervical dilatation was significantly lower whereas the baseline cervical dilatation was significantly greater in the misoprostol group. We conclude that oral misoprostol is effective for pre-operative cervical dilatation in non-pregnant women. | Difficulties with entering the internal cervical os in nonpregnant women (especially nulliparous women) can hinder performance of endometrial aspiration or hysteroscopy in patients presenting with abnormal vaginal bleeding. This study investigated the usefulness of oral misoprostol--shown to be effective in cervical dilatation in first and third trimester abortion--for preoperative cervical dilatation in non-pregnant women. 44 nulliparous women presenting to Hong Kong's Queen Mary Hospital for diagnostic hysteroscopy and endometrial biopsy and curettage were randomly assigned to receive either 400 mcg of misoprostol 12 hours prior to the procedure (n = 21) or placebo (n = 23). Pretreatment with misoprostol significantly reduced the amount of force required to dilate the cervix to 8 mm from 103.7 Newtons in controls to 40.0 Newtons in women treated with misoprostol. The mean baseline cervical dilatation was significantly greater in the misoprostol group (6.0 mm) than in controls (3.3 mm). There were no immediate intraoperative complications and all women were discharged within 12 hours of the procedure. Another potential use of misoprostol is for cervical dilatation prior to IUD insertion in nulliparous women.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectCervical primingen_HK
dc.subjectNon-pregnant womenen_HK
dc.subjectOral misoprostolen_HK
dc.titleOral misoprostol for cervical priming in non-pregnant womenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=12&issue=11&spage=2373&epage=2375&date=1997&atitle=Oral+misoprostol+for+cervical+priming+in+non-pregnant+womenen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1093/humrep/12.11.2373en_HK
dc.identifier.pmid9436666-
dc.identifier.scopuseid_2-s2.0-0030859736en_HK
dc.identifier.hkuros30447-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030859736&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2373en_HK
dc.identifier.epage2375en_HK
dc.identifier.isiWOS:000071818700009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridNgai, SW=7006074214en_HK
dc.identifier.scopusauthoridChan, YM=7403676661en_HK
dc.identifier.scopusauthoridLiu, KL=7404200677en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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