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Article: Distinct mutational spectrum of the p53 gene in lung cancers from Chinese women in Hong Kong

TitleDistinct mutational spectrum of the p53 gene in lung cancers from Chinese women in Hong Kong
Authors
Issue Date1995
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1995, v. 55 n. 22, p. 5354-5357 How to Cite?
AbstractAccumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies to search for risk factors in carcinogenic events. The lung cancer incidence for females in Hong Kong is unusually high, ranking among the highest in the world despite a low percentage with a history of smoking. To gain insights into possible etiological risk factors responsible for this high incidence, we examined p53 mutations in 35 lung cancer specimens from Chinese females living in Hong Kong and compared them with 35 matched cases from Japanese women as well as previously reported p53 mutations in the world literature. p53 mutations in exons 5-8 were present in 20 and 31% of the Hong Kong and Japanese cases, respectively. Notably, single-base deletions within runs of identical bases were observed in 3 (43%) of the 7 mutations in the Hong Kong cases, in contrast to the absence of such mutations in the controls and the extreme scarcity in the literature, suggesting that distinct environmental and/or genetic factor(s) might be involved. Although the frequent occurrence of characteristic single-base deletions could be a reflection of mutator mutations leading to inefficient mismatch repair of slipped strand mispairings, none of the lung cancer specimens exhibited such microsatellite instabilities.
Persistent Identifierhttp://hdl.handle.net/10722/49378
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTakagi, Yen_HK
dc.contributor.authorKoo, LCen_HK
dc.contributor.authorOsada, Hen_HK
dc.contributor.authorUeda, Ren_HK
dc.contributor.authorKyaw, Ken_HK
dc.contributor.authorMa, CCen_HK
dc.contributor.authorSuyama, Men_HK
dc.contributor.authorSaji, Sen_HK
dc.contributor.authorTakahashi, Ten_HK
dc.contributor.authorTominaga, Sen_HK
dc.date.accessioned2008-06-12T06:40:51Z-
dc.date.available2008-06-12T06:40:51Z-
dc.date.issued1995en_HK
dc.identifier.citationCancer Research, 1995, v. 55 n. 22, p. 5354-5357en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49378-
dc.description.abstractAccumulating evidence suggests that the p53 gene is a good target for molecular epidemiological studies to search for risk factors in carcinogenic events. The lung cancer incidence for females in Hong Kong is unusually high, ranking among the highest in the world despite a low percentage with a history of smoking. To gain insights into possible etiological risk factors responsible for this high incidence, we examined p53 mutations in 35 lung cancer specimens from Chinese females living in Hong Kong and compared them with 35 matched cases from Japanese women as well as previously reported p53 mutations in the world literature. p53 mutations in exons 5-8 were present in 20 and 31% of the Hong Kong and Japanese cases, respectively. Notably, single-base deletions within runs of identical bases were observed in 3 (43%) of the 7 mutations in the Hong Kong cases, in contrast to the absence of such mutations in the controls and the extreme scarcity in the literature, suggesting that distinct environmental and/or genetic factor(s) might be involved. Although the frequent occurrence of characteristic single-base deletions could be a reflection of mutator mutations leading to inefficient mismatch repair of slipped strand mispairings, none of the lung cancer specimens exhibited such microsatellite instabilities.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshGenes, p53en_HK
dc.subject.meshLung neoplasm - etiology - geneticsen_HK
dc.subject.meshMutationen_HK
dc.subject.meshDNA satellite - geneticsen_HK
dc.titleDistinct mutational spectrum of the p53 gene in lung cancers from Chinese women in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-5472&volume=55&issue=22&spage=5354&epage=5357&date=1995&atitle=Distinct+mutational+spectrum+of+the+p53+gene+in+lung+cancers+from+Chinese+women+in+Hong+Kongen_HK
dc.identifier.emailKoo, LC: hrmrklc@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid7585600-
dc.identifier.scopuseid_2-s2.0-0028885113-
dc.identifier.hkuros8934-
dc.identifier.isiWOS:A1995TD88700042-

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