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Article: Breast milk dioxins in Hong Kong and Pearl River Delta

TitleBreast milk dioxins in Hong Kong and Pearl River Delta
Authors
KeywordsBreast milk
China
Dioxin-like polychlorinated biphenyls
Hong Kong
Polychlorinated dibenzo-para-dioxins
Polychlorinated dibenzofurans
Issue Date2006
PublisherUS Department of Health and Human Services, National Institute of Environmental Health Sciences. The Journal's web site is located at http://ehp.niehs.nih.gov/
Citation
Environmental Health Perspectives, 2006, v. 114 n. 2, p. 202-208 How to Cite?
AbstractThere are no previous reports from South China on chemically determined polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) in human breast milk expressed as World Health Organization (WHO) toxic equivalents (TEQs). In a 2002-2003 WHO exposure study, 13 pools of breast milk comprising samples from 316 primiparous women in Hong Kong in 2002 were analyzed by gas chromatography/mass spectrometry for 29 PCDD/F and dioxin-like PCB congeners. Total WHO-TEQs, ranged from 8.97 to 16.7 pg/g fat (weighted mean, 12.9 pg; weighted median, 13.4 pg). Variations in TEQs included positive associations with age (R2 = 0.73, p < 0.0005), higher consumption of dairy products and seafood, and lower TEQs in overseas mothers and eversmokers. Congener profiles indicated geographic specificity of exposure in Hong Kong, mainland China, and overseas Asian countries, including higher proportions of PCB-TEQs (overseas) and PCDF-TEQs (mainland China). The median TEQs of PCDD/Fs (8.69 pg/g fat) and PCBs 4.73 pg/g fat) in Hong Kong were highest among the five Asian Pacific countries but lower than the levels for at least half of the European countries that participated in the WHO study. However, future international studies should incorporate mother's age in the design of the pooling strategy to allow standardization by other exposure factors and valid comparisons among different countries. The findings allow support for the WHO breast-feeding advisory. Trends in human dioxin levels in the region cannot yet be determined, and rigorous controls are needed to reduce emissions of dioxins and human exposure in mainland China.
Persistent Identifierhttp://hdl.handle.net/10722/49365
ISSN
2015 Impact Factor: 8.443
2015 SCImago Journal Rankings: 3.529
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHedley, AJen_HK
dc.contributor.authorWong, TWen_HK
dc.contributor.authorHui, LLen_HK
dc.contributor.authorMalisch, Ren_HK
dc.contributor.authorNelson, EASen_HK
dc.date.accessioned2008-06-12T06:40:33Z-
dc.date.available2008-06-12T06:40:33Z-
dc.date.issued2006en_HK
dc.identifier.citationEnvironmental Health Perspectives, 2006, v. 114 n. 2, p. 202-208en_HK
dc.identifier.issn0091-6765en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49365-
dc.description.abstractThere are no previous reports from South China on chemically determined polychlorinated dibenzo-para-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like polychlorinated biphenyls (PCBs) in human breast milk expressed as World Health Organization (WHO) toxic equivalents (TEQs). In a 2002-2003 WHO exposure study, 13 pools of breast milk comprising samples from 316 primiparous women in Hong Kong in 2002 were analyzed by gas chromatography/mass spectrometry for 29 PCDD/F and dioxin-like PCB congeners. Total WHO-TEQs, ranged from 8.97 to 16.7 pg/g fat (weighted mean, 12.9 pg; weighted median, 13.4 pg). Variations in TEQs included positive associations with age (R2 = 0.73, p < 0.0005), higher consumption of dairy products and seafood, and lower TEQs in overseas mothers and eversmokers. Congener profiles indicated geographic specificity of exposure in Hong Kong, mainland China, and overseas Asian countries, including higher proportions of PCB-TEQs (overseas) and PCDF-TEQs (mainland China). The median TEQs of PCDD/Fs (8.69 pg/g fat) and PCBs 4.73 pg/g fat) in Hong Kong were highest among the five Asian Pacific countries but lower than the levels for at least half of the European countries that participated in the WHO study. However, future international studies should incorporate mother's age in the design of the pooling strategy to allow standardization by other exposure factors and valid comparisons among different countries. The findings allow support for the WHO breast-feeding advisory. Trends in human dioxin levels in the region cannot yet be determined, and rigorous controls are needed to reduce emissions of dioxins and human exposure in mainland China.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherUS Department of Health and Human Services, National Institute of Environmental Health Sciences. The Journal's web site is located at http://ehp.niehs.nih.gov/en_HK
dc.relation.ispartofEnvironmental Health Perspectivesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBreast milken_HK
dc.subjectChinaen_HK
dc.subjectDioxin-like polychlorinated biphenylsen_HK
dc.subjectHong Kongen_HK
dc.subjectPolychlorinated dibenzo-para-dioxinsen_HK
dc.subjectPolychlorinated dibenzofuransen_HK
dc.subject.meshBenzofurans - analysisen_HK
dc.subject.meshBreast Feedingen_HK
dc.subject.meshEnvironmental Pollutants - analysisen_HK
dc.subject.meshMilk, Human - chemistryen_HK
dc.subject.meshPolychlorinated Biphenyls - analysisen_HK
dc.titleBreast milk dioxins in Hong Kong and Pearl River Deltaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0091-6765&volume=114&issue=2&spage=202&epage=208&date=2006&atitle=Breast+milk+dioxins+in+Hong+Kong+and+Pearl+River+Deltaen_HK
dc.identifier.emailHedley, AJ: hrmrajh@hkucc.hku.hken_HK
dc.identifier.emailHui, LL: huic@hkucc.hku.hken_HK
dc.identifier.authorityHedley, AJ=rp00357en_HK
dc.identifier.authorityHui, LL=rp01698en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1289/ehp.8116en_HK
dc.identifier.pmid16451855en_HK
dc.identifier.pmcidPMC1367832en_HK
dc.identifier.scopuseid_2-s2.0-32044456040en_HK
dc.identifier.hkuros114186-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32044456040&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue2en_HK
dc.identifier.spage202en_HK
dc.identifier.epage208en_HK
dc.identifier.isiWOS:000235226300038-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHedley, AJ=7102584095en_HK
dc.identifier.scopusauthoridWong, TW=7403531744en_HK
dc.identifier.scopusauthoridHui, LL=12774460100en_HK
dc.identifier.scopusauthoridMalisch, R=6701317539en_HK
dc.identifier.scopusauthoridNelson, EAS=7402264387en_HK

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