Article: Treatment of Biliary Atresia by Portoenterostomy and Liver Transplantation: The Queen Mary Hospital, Hong Kong Experience

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TitleTreatment of Biliary Atresia by Portoenterostomy and Liver Transplantation: The Queen Mary Hospital, Hong Kong Experience
AuthorsSaing, H1
Fan, ST1
Chan, KL
Wei, W1
Mya, GH1
Lo, CM1
Cheng, W1
KeywordsBiliary atresia
Liver transplantation
Microvascular surgery
Portoenterostomy
Issue Date1997
PublisherTohoku University Medical Press. The Journal's web site is located at http://journal.med.tohoku.ac.jp/
CitationTohoku Journal Of Experimental Medicine, 1997, v. 181 n. 1, p. 109-116 [How to Cite?]
DOI: http://dx.doi.org/10.1620/tjem.181.109
AbstractNinety three out of 96 patients with biliary atresia (BA) underwent Kasai 1 portoenterostomy and 11 children subsequently underwent 12 liver transplantation (LTX) procedures which included 8 living related liver transplants (LRLT), 3 reduced-size liver transplants (RSLT) and 1 orthotopic liver transplantation (OLT). During a follow-up period of 3-206 months (mean, 73 months) after portoenterostomy and 3-63 months after LTX, 50% of 96 patients are alive and well with total clearance of jaundice while 12% are mildly jaundiced, 10% are deeply jaundiced and 28% have died. Two of the 3 patients who did not undergo portoenterostomy and 25 from the portoenterostomy group have died. Of the latter group, 22 deaths occurred before, and 3 after the introduction of LTX therapy respectively. Of the 68 long-term survivors, 32 are less than 5, and 36 are 6-17 years old. Complete clearance of jaundice was achieved in 55% of patients irrespective of whether portoenterostomy was initially performed at <10 or between 10 and 12 weeks. Portoenterostomy performed beyond 13 weeks was associated with declining results. We conclude that (1) portoenterostomy combined with liver transplantation, when indicated, has given patients with BA a much better prognosis and (2) pediatric LTX in our institute is a well established procedure with 100% patient and 88% primary graft survival.
ISSN0040-8727
2011 Impact Factor: 1.244
2011 SCImago Journal Rankings: 0.106
DOIhttp://dx.doi.org/10.1620/tjem.181.109
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSaing, H
dc.contributor.authorFan, ST
dc.contributor.authorChan, KL
dc.contributor.authorWei, W
dc.contributor.authorMya, GH
dc.contributor.authorLo, CM
dc.contributor.authorCheng, W
dc.date.accessioned2008-06-12T06:39:18Z
dc.date.available2008-06-12T06:39:18Z
dc.date.issued1997
dc.description.abstractNinety three out of 96 patients with biliary atresia (BA) underwent Kasai 1 portoenterostomy and 11 children subsequently underwent 12 liver transplantation (LTX) procedures which included 8 living related liver transplants (LRLT), 3 reduced-size liver transplants (RSLT) and 1 orthotopic liver transplantation (OLT). During a follow-up period of 3-206 months (mean, 73 months) after portoenterostomy and 3-63 months after LTX, 50% of 96 patients are alive and well with total clearance of jaundice while 12% are mildly jaundiced, 10% are deeply jaundiced and 28% have died. Two of the 3 patients who did not undergo portoenterostomy and 25 from the portoenterostomy group have died. Of the latter group, 22 deaths occurred before, and 3 after the introduction of LTX therapy respectively. Of the 68 long-term survivors, 32 are less than 5, and 36 are 6-17 years old. Complete clearance of jaundice was achieved in 55% of patients irrespective of whether portoenterostomy was initially performed at <10 or between 10 and 12 weeks. Portoenterostomy performed beyond 13 weeks was associated with declining results. We conclude that (1) portoenterostomy combined with liver transplantation, when indicated, has given patients with BA a much better prognosis and (2) pediatric LTX in our institute is a well established procedure with 100% patient and 88% primary graft survival.
dc.description.naturepublished_or_final_version
dc.format.extent418 bytes
dc.format.mimetypetext/html
dc.identifier.citationTohoku Journal Of Experimental Medicine, 1997, v. 181 n. 1, p. 109-116 [How to Cite?]
DOI: http://dx.doi.org/10.1620/tjem.181.109
dc.identifier.doihttp://dx.doi.org/10.1620/tjem.181.109
dc.identifier.epage116
dc.identifier.hkuros24215
dc.identifier.isiWOS:A1997WP06600013
dc.identifier.issn0040-8727
2011 Impact Factor: 1.244
2011 SCImago Journal Rankings: 0.106
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid9149345
dc.identifier.scopuseid_2-s2.0-0030632749
dc.identifier.spage109
dc.identifier.urihttp://hdl.handle.net/10722/49316
dc.identifier.volume181
dc.languageeng
dc.publisherTohoku University Medical Press. The Journal's web site is located at http://journal.med.tohoku.ac.jp/
dc.publisher.placeJapan
dc.relation.ispartofTohoku Journal of Experimental Medicine
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectBiliary atresia
dc.subjectLiver transplantation
dc.subjectMicrovascular surgery
dc.subjectPortoenterostomy
dc.titleTreatment of Biliary Atresia by Portoenterostomy and Liver Transplantation: The Queen Mary Hospital, Hong Kong Experience
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong