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Article: Treatment of Biliary Atresia by Portoenterostomy and Liver Transplantation: The Queen Mary Hospital, Hong Kong Experience

TitleTreatment of Biliary Atresia by Portoenterostomy and Liver Transplantation: The Queen Mary Hospital, Hong Kong Experience
Authors
KeywordsBiliary atresia
Liver transplantation
Microvascular surgery
Portoenterostomy
Issue Date1997
PublisherTohoku University Medical Press. The Journal's web site is located at http://journal.med.tohoku.ac.jp/
Citation
Tohoku Journal Of Experimental Medicine, 1997, v. 181 n. 1, p. 109-116 How to Cite?
AbstractNinety three out of 96 patients with biliary atresia (BA) underwent Kasai 1 portoenterostomy and 11 children subsequently underwent 12 liver transplantation (LTX) procedures which included 8 living related liver transplants (LRLT), 3 reduced-size liver transplants (RSLT) and 1 orthotopic liver transplantation (OLT). During a follow-up period of 3-206 months (mean, 73 months) after portoenterostomy and 3-63 months after LTX, 50% of 96 patients are alive and well with total clearance of jaundice while 12% are mildly jaundiced, 10% are deeply jaundiced and 28% have died. Two of the 3 patients who did not undergo portoenterostomy and 25 from the portoenterostomy group have died. Of the latter group, 22 deaths occurred before, and 3 after the introduction of LTX therapy respectively. Of the 68 long-term survivors, 32 are less than 5, and 36 are 6-17 years old. Complete clearance of jaundice was achieved in 55% of patients irrespective of whether portoenterostomy was initially performed at <10 or between 10 and 12 weeks. Portoenterostomy performed beyond 13 weeks was associated with declining results. We conclude that (1) portoenterostomy combined with liver transplantation, when indicated, has given patients with BA a much better prognosis and (2) pediatric LTX in our institute is a well established procedure with 100% patient and 88% primary graft survival.
Persistent Identifierhttp://hdl.handle.net/10722/49316
ISSN
2015 Impact Factor: 1.287
2015 SCImago Journal Rankings: 0.567
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSaing, Hen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorChan, KLen_HK
dc.contributor.authorWei, Wen_HK
dc.contributor.authorMya, GHen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorCheng, Wen_HK
dc.date.accessioned2008-06-12T06:39:18Z-
dc.date.available2008-06-12T06:39:18Z-
dc.date.issued1997en_HK
dc.identifier.citationTohoku Journal Of Experimental Medicine, 1997, v. 181 n. 1, p. 109-116en_HK
dc.identifier.issn0040-8727en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49316-
dc.description.abstractNinety three out of 96 patients with biliary atresia (BA) underwent Kasai 1 portoenterostomy and 11 children subsequently underwent 12 liver transplantation (LTX) procedures which included 8 living related liver transplants (LRLT), 3 reduced-size liver transplants (RSLT) and 1 orthotopic liver transplantation (OLT). During a follow-up period of 3-206 months (mean, 73 months) after portoenterostomy and 3-63 months after LTX, 50% of 96 patients are alive and well with total clearance of jaundice while 12% are mildly jaundiced, 10% are deeply jaundiced and 28% have died. Two of the 3 patients who did not undergo portoenterostomy and 25 from the portoenterostomy group have died. Of the latter group, 22 deaths occurred before, and 3 after the introduction of LTX therapy respectively. Of the 68 long-term survivors, 32 are less than 5, and 36 are 6-17 years old. Complete clearance of jaundice was achieved in 55% of patients irrespective of whether portoenterostomy was initially performed at <10 or between 10 and 12 weeks. Portoenterostomy performed beyond 13 weeks was associated with declining results. We conclude that (1) portoenterostomy combined with liver transplantation, when indicated, has given patients with BA a much better prognosis and (2) pediatric LTX in our institute is a well established procedure with 100% patient and 88% primary graft survival.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherTohoku University Medical Press. The Journal's web site is located at http://journal.med.tohoku.ac.jp/en_HK
dc.relation.ispartofTohoku Journal of Experimental Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBiliary atresiaen_HK
dc.subjectLiver transplantationen_HK
dc.subjectMicrovascular surgeryen_HK
dc.subjectPortoenterostomyen_HK
dc.titleTreatment of Biliary Atresia by Portoenterostomy and Liver Transplantation: The Queen Mary Hospital, Hong Kong Experienceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0040-8727&volume=181&issue=1&spage=109&epage=116&date=1997&atitle=Treatment+of+biliary+atresia+by+portoenterostomy+and+liver+transplantation:+the+Queen+Mary+Hospital,+Hong+Kong+experienceen_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWei, W: hrmswwi@hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWei, W=rp00323en_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1620/tjem.181.109en_HK
dc.identifier.pmid9149345en_HK
dc.identifier.scopuseid_2-s2.0-0030632749en_HK
dc.identifier.hkuros24215-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030632749&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume181en_HK
dc.identifier.issue1en_HK
dc.identifier.spage109en_HK
dc.identifier.epage116en_HK
dc.identifier.isiWOS:A1997WP06600013-
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridSaing, H=7005715754en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridChan, KL=37004089600en_HK
dc.identifier.scopusauthoridWei, W=7403321552en_HK
dc.identifier.scopusauthoridMya, GH=6602928992en_HK
dc.identifier.scopusauthoridLo, CM=7401771672en_HK
dc.identifier.scopusauthoridCheng, W=7402169228en_HK

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