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Article: Adrenergic mechanisms in canine nasal venous systems

TitleAdrenergic mechanisms in canine nasal venous systems
Authors
KeywordsAgonist
Alpha-adrenoceptor
Antagonist
Beta-adrenoceptor
Isometric tension
Nasal
Transmural nerve stimulation
Vein
Issue Date2003
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 2003, v. 138 n. 1, p. 145-155 How to Cite?
Abstract1. We investigated the adrenergic mechanisms of the two venous systems that drain the nasal mucosa, thereby their exact role in eliciting nasal decongestion. The action of endogenously released noradrenaline and exogenous adrenergic agonists on different segments of the nasal venous systems, i.e. collecting (LCV, SCV) and outflow (SPV) veins of posterior venous system, collecting (ACV) and outflow (DNV) veins of anterior venous system and venous sinusoids of the septal mucosa (SM), were studied. In vitro isometric tension of the vascular segments was measured. 2. Transmural nerve stimulation (TNS) produced constriction in ACV, DNV and SM, primary constriction followed by secondary dilatation in LCV and SCV and dilatation in SPV. Tetrodotoxin (10 -6 M) abolished all responses. Phentolamine (10 -6 M), prazosin (10 -6 M) and rauwolscine (10 -7 M) inhibited the constriction in all venous vessels. Propranolol (10 -6 M), atenolol (10 -6 M) and ICI 118,551 (10 -6 M) inhibited the relaxation in SPV but not in LCV and SCV. Phenylephrine and clonidine constricted whereas dobutamine and terbutaline relaxed all venous vessels dose-dependently. 3. These results indicate α 1-, α 2-, β 1- and β 2-adrenoceptors are present in both venous systems. TNS causes constriction of anterior venous system, venous sinusoids and posterior collecting veins primarily via postjunctional α 2-adrenoceptors but relaxation of posterior outflow vein equally via postjunctional β 1- and β 2-adrenoceptors. The combined action of the two adrenergic mechanisms can reduce nasal airway resistance in vivo by decreasing vascular capacitance and enhancing venous drainage via the posterior venous system.
Persistent Identifierhttp://hdl.handle.net/10722/49307
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Men_HK
dc.contributor.authorLung, MAen_HK
dc.date.accessioned2008-06-12T06:39:00Z-
dc.date.available2008-06-12T06:39:00Z-
dc.date.issued2003en_HK
dc.identifier.citationBritish Journal Of Pharmacology, 2003, v. 138 n. 1, p. 145-155en_HK
dc.identifier.issn0007-1188en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49307-
dc.description.abstract1. We investigated the adrenergic mechanisms of the two venous systems that drain the nasal mucosa, thereby their exact role in eliciting nasal decongestion. The action of endogenously released noradrenaline and exogenous adrenergic agonists on different segments of the nasal venous systems, i.e. collecting (LCV, SCV) and outflow (SPV) veins of posterior venous system, collecting (ACV) and outflow (DNV) veins of anterior venous system and venous sinusoids of the septal mucosa (SM), were studied. In vitro isometric tension of the vascular segments was measured. 2. Transmural nerve stimulation (TNS) produced constriction in ACV, DNV and SM, primary constriction followed by secondary dilatation in LCV and SCV and dilatation in SPV. Tetrodotoxin (10 -6 M) abolished all responses. Phentolamine (10 -6 M), prazosin (10 -6 M) and rauwolscine (10 -7 M) inhibited the constriction in all venous vessels. Propranolol (10 -6 M), atenolol (10 -6 M) and ICI 118,551 (10 -6 M) inhibited the relaxation in SPV but not in LCV and SCV. Phenylephrine and clonidine constricted whereas dobutamine and terbutaline relaxed all venous vessels dose-dependently. 3. These results indicate α 1-, α 2-, β 1- and β 2-adrenoceptors are present in both venous systems. TNS causes constriction of anterior venous system, venous sinusoids and posterior collecting veins primarily via postjunctional α 2-adrenoceptors but relaxation of posterior outflow vein equally via postjunctional β 1- and β 2-adrenoceptors. The combined action of the two adrenergic mechanisms can reduce nasal airway resistance in vivo by decreasing vascular capacitance and enhancing venous drainage via the posterior venous system.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_HK
dc.relation.ispartofBritish Journal of Pharmacologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAgonisten_HK
dc.subjectAlpha-adrenoceptoren_HK
dc.subjectAntagonisten_HK
dc.subjectBeta-adrenoceptoren_HK
dc.subjectIsometric tensionen_HK
dc.subjectNasalen_HK
dc.subjectTransmural nerve stimulationen_HK
dc.subjectVeinen_HK
dc.titleAdrenergic mechanisms in canine nasal venous systemsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1188&volume=138&issue=1&spage=145&epage=155&date=2003&atitle=Adrenergic+mechanisms+in+canine+nasal+venous+systemsen_HK
dc.identifier.emailWang, M: memwang@hku.hken_HK
dc.identifier.emailLung, MA: makylung@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.identifier.authorityLung, MA=rp00319en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1038/sj.bjp.0705020en_HK
dc.identifier.pmid12522084en_HK
dc.identifier.pmcidPMC1573646en_HK
dc.identifier.scopuseid_2-s2.0-0037275555en_HK
dc.identifier.hkuros81684-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037275555&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume138en_HK
dc.identifier.issue1en_HK
dc.identifier.spage145en_HK
dc.identifier.epage155en_HK
dc.identifier.isiWOS:000180782900020-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK
dc.identifier.scopusauthoridLung, MA=7006411781en_HK

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