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Article: In vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigs

TitleIn vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigs
Authors
Issue Date2004
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751
Citation
Journal Of Physiology, 2004, v. 560 n. 1, p. 191-205 How to Cite?
AbstractIn the present study, we investigated the auditory response features of the medial geniculate neurones, using in vivo intracellular recordings in anaesthetized guinea pigs. Of the 76 neurones examined, 9 showed 'off' or 'on-off' responses to an acoustic stimulus and thus were defined as 'off' or 'on-off' neurones. Among the remaining 67 neurones, 42 showed an excitatory postsynaptic potential (EPSP) to acoustic stimuli and 25 showed either a pure inhibitory postsynaptic potential (IPSP, 7 neurones), or an IPSP preceded by an EPSP (EPSP-IPSP type, 18 neurones). The EPSP responses exhibited a mean latency of 15.7 ± 6.1 ms, which was significantly shorter than that of the IPSP responses (21.3 ± 8.6 ms, P < 0.01). The IPSP responses also showed a significantly greater duration than the EPSP responses (208.5 ± 128.2 ms versus 122.4 ± 84.8 ms, P < 0.05), while there were no significant differences between the amplitudes of IPSP and EPSP (8.3 ± 3.2 mV versus 8.7 ± 5.3 mV). Of the 11 neurones that showed EPSP responses to acoustic stimuli and were histologically labelled, 7 were located in the lemniscal medial geniculate body (MGB) and 4 in the non-lemniscal MGB. Another 6 labelled neurones that showed IPSP responses to acoustic stimuli were located in the non-lemniscal MGB. With a membrane potential of above - 72 mV, the neurones showed greater EPSP or IPSP to an acoustic stimulus when their membrane potential was depolarized. However, upon hyperpolarization to below - 74 mV, the neurones shifted to low-threshold calcium spikes (LTS)/LTS bursts. In response to auditory stimuli of different durations, 'off' neurones that responded to the offset of the acoustic stimulus and were located in the non-lemniscal MGB showed different response latencies or deviations of latencies in addition to exhibiting different numbers of spikes, suggesting that the timing of the spikes could be another component utilized by thalamic neurones to encode information on the stimulus. Given that some non-lemniscal neurones are multisensory and project to the entire auditory cortex, the selective corticofugal inhibition in the non-lemniscal MGB would enable the ascending pathway to prepare the auditory cortex to receive subsequent auditory information, avoiding the interference of other sensory inputs. © The Physiological Society 2004.
Persistent Identifierhttp://hdl.handle.net/10722/49285
ISSN
2015 Impact Factor: 4.731
2015 SCImago Journal Rankings: 2.670
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, YQen_HK
dc.contributor.authorXiong, Yen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2008-06-12T06:38:32Z-
dc.date.available2008-06-12T06:38:32Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Physiology, 2004, v. 560 n. 1, p. 191-205en_HK
dc.identifier.issn0022-3751en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49285-
dc.description.abstractIn the present study, we investigated the auditory response features of the medial geniculate neurones, using in vivo intracellular recordings in anaesthetized guinea pigs. Of the 76 neurones examined, 9 showed 'off' or 'on-off' responses to an acoustic stimulus and thus were defined as 'off' or 'on-off' neurones. Among the remaining 67 neurones, 42 showed an excitatory postsynaptic potential (EPSP) to acoustic stimuli and 25 showed either a pure inhibitory postsynaptic potential (IPSP, 7 neurones), or an IPSP preceded by an EPSP (EPSP-IPSP type, 18 neurones). The EPSP responses exhibited a mean latency of 15.7 ± 6.1 ms, which was significantly shorter than that of the IPSP responses (21.3 ± 8.6 ms, P < 0.01). The IPSP responses also showed a significantly greater duration than the EPSP responses (208.5 ± 128.2 ms versus 122.4 ± 84.8 ms, P < 0.05), while there were no significant differences between the amplitudes of IPSP and EPSP (8.3 ± 3.2 mV versus 8.7 ± 5.3 mV). Of the 11 neurones that showed EPSP responses to acoustic stimuli and were histologically labelled, 7 were located in the lemniscal medial geniculate body (MGB) and 4 in the non-lemniscal MGB. Another 6 labelled neurones that showed IPSP responses to acoustic stimuli were located in the non-lemniscal MGB. With a membrane potential of above - 72 mV, the neurones showed greater EPSP or IPSP to an acoustic stimulus when their membrane potential was depolarized. However, upon hyperpolarization to below - 74 mV, the neurones shifted to low-threshold calcium spikes (LTS)/LTS bursts. In response to auditory stimuli of different durations, 'off' neurones that responded to the offset of the acoustic stimulus and were located in the non-lemniscal MGB showed different response latencies or deviations of latencies in addition to exhibiting different numbers of spikes, suggesting that the timing of the spikes could be another component utilized by thalamic neurones to encode information on the stimulus. Given that some non-lemniscal neurones are multisensory and project to the entire auditory cortex, the selective corticofugal inhibition in the non-lemniscal MGB would enable the ascending pathway to prepare the auditory cortex to receive subsequent auditory information, avoiding the interference of other sensory inputs. © The Physiological Society 2004.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3751en_HK
dc.relation.ispartofJournal of Physiologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe Journal of Physiology. Copyright © Blackwell Publishing Ltd.en_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_HK
dc.subject.meshBiotin - analogs & derivativesen_HK
dc.subject.meshEvoked Potentials, Auditory - physiologyen_HK
dc.subject.meshGeniculate Bodies - cytology - physiologyen_HK
dc.subject.meshNeurons - physiologyen_HK
dc.subject.meshAcoustic Stimulationen_HK
dc.titleIn vivo intracellular responses of the medial geniculate neurones to acoustic stimuli in anaesthetized guinea pigsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3751&volume=560&issue=1&spage=191&epage=205&date=2004&atitle=In+vivo+intracellular+responses+of+the+medial+geniculate+neurones+to+acoustic+stimuli+in+anaesthetized+guinea+pigsen_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1113/jphysiol.2004.067678en_HK
dc.identifier.pmid15272038-
dc.identifier.pmcidPMC1665209en_HK
dc.identifier.scopuseid_2-s2.0-6444222032en_HK
dc.identifier.hkuros106637-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-6444222032&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume560en_HK
dc.identifier.issue1en_HK
dc.identifier.spage191en_HK
dc.identifier.epage205en_HK
dc.identifier.isiWOS:000224464300016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYu, YQ=7406253532en_HK
dc.identifier.scopusauthoridXiong, Y=8706548900en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK
dc.identifier.scopusauthoridHe, J=7404984971en_HK

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