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Article: Endothelium-dependent contractions in hypertension

TitleEndothelium-dependent contractions in hypertension
Authors
KeywordsArachidonic acid
Endoperoxides
Endothelin
Hypertension
Nitric oxide
Superoxide anions
Thromboxane A2
TP-receptors
Issue Date2005
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1
Citation
British Journal Of Pharmacology, 2005, v. 144 n. 4, p. 449-458 How to Cite?
AbstractEndothelial cells, under given circumstances, can initiate contraction (constriction) of the vascular smooth muscle cells that surround them. Such endothelium-dependent, acute increases in contractile tone can be due to the withdrawal of the production of nitric oxide, to the production of vasoconstrictor peptides (angiotensin II, endothelin-1), to the formation of oxygen-derived free radicals (superoxide anions) and/or the release of vasoconstrictor metabolites of arachidonic acid. The latter have been termed endothelium-derived contracting factor (EDCF) as they can contribute to moment-to-moment changes in contractile activity of the underlying vascular smooth muscle cells. To judge from animal experiments, EDCF-mediated responses are exacerbated by aging, spontaneous hypertension and diabetes. To judge from human studies, they contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients. Since EDCF causes vasoconstriction by activation of the TP-receptors on the vascular smooth muscle cells, selective antagonists at these receptors prevent endothelium-dependent contractions, and curtail the endothelial dysfunction in hypertension and diabetes. © 2005 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/49282
ISSN
2015 Impact Factor: 5.259
2015 SCImago Journal Rankings: 2.368
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorFeletou, Men_HK
dc.contributor.authorTaddei, Sen_HK
dc.date.accessioned2008-06-12T06:38:25Z-
dc.date.available2008-06-12T06:38:25Z-
dc.date.issued2005en_HK
dc.identifier.citationBritish Journal Of Pharmacology, 2005, v. 144 n. 4, p. 449-458en_HK
dc.identifier.issn0007-1188en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49282-
dc.description.abstractEndothelial cells, under given circumstances, can initiate contraction (constriction) of the vascular smooth muscle cells that surround them. Such endothelium-dependent, acute increases in contractile tone can be due to the withdrawal of the production of nitric oxide, to the production of vasoconstrictor peptides (angiotensin II, endothelin-1), to the formation of oxygen-derived free radicals (superoxide anions) and/or the release of vasoconstrictor metabolites of arachidonic acid. The latter have been termed endothelium-derived contracting factor (EDCF) as they can contribute to moment-to-moment changes in contractile activity of the underlying vascular smooth muscle cells. To judge from animal experiments, EDCF-mediated responses are exacerbated by aging, spontaneous hypertension and diabetes. To judge from human studies, they contribute to the blunting of endothelium-dependent vasodilatations in aged subjects and essential hypertensive patients. Since EDCF causes vasoconstriction by activation of the TP-receptors on the vascular smooth muscle cells, selective antagonists at these receptors prevent endothelium-dependent contractions, and curtail the endothelial dysfunction in hypertension and diabetes. © 2005 Nature Publishing Group All rights reserved.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0007-1188&site=1en_HK
dc.relation.ispartofBritish Journal of Pharmacologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectArachidonic aciden_HK
dc.subjectEndoperoxidesen_HK
dc.subjectEndothelinen_HK
dc.subjectHypertensionen_HK
dc.subjectNitric oxideen_HK
dc.subjectSuperoxide anionsen_HK
dc.subjectThromboxane A2en_HK
dc.subjectTP-receptorsen_HK
dc.titleEndothelium-dependent contractions in hypertensionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1188&volume=144&issue=4&spage=449&epage=458&date=2005&atitle=Endothelium-dependent+contractions+in+hypertensionen_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1038/sj.bjp.0706042en_HK
dc.identifier.pmid15655530-
dc.identifier.pmcidPMC1576026en_HK
dc.identifier.scopuseid_2-s2.0-14844320534en_HK
dc.identifier.hkuros97742-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14844320534&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume144en_HK
dc.identifier.issue4en_HK
dc.identifier.spage449en_HK
dc.identifier.epage458en_HK
dc.identifier.isiWOS:000227330600001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridFeletou, M=7006461826en_HK
dc.identifier.scopusauthoridTaddei, S=7007037060en_HK

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