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Article: Cigarette smoking delays ulcer healing: role of constitutive nitric oxide synthase in rat stomach

TitleCigarette smoking delays ulcer healing: role of constitutive nitric oxide synthase in rat stomach
Authors
KeywordsGastric blood flow
Angiogenesis
Prostaglandin E2
gastric blooL-arginine
Issue Date1999
PublisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpgi.physiology.org/
Citation
American Journal of Physiology: Gastrointestinal and Liver Physiology, 1999, v. 276 n. 1, p. G238-G248 How to Cite?
AbstractEpidemiological studies have shown that cigarette smoking is associated with peptic ulceration. This study aims to investigate the mechanisms by which cigarette smoking delays ulcer healing in rats. Gastric ulcers were induced by applying acetic acid to the luminal surfaces in rats. Twenty-four hours later, rats were exposed to different concentrations of cigarette smoke (0, 2, or 4%) for a 1-h period once daily for 3 or 6 days. Cigarette smoke exposure delayed ulcer healing and decreased gastric blood flow and angiogenesis at the ulcer margin. These changes were accompanied by a significant reduction of constitutive nitric oxide synthase (cNOS) activity but not PGE2 production and vascular endothelial growth factor levels. Administration of L-arginine (10 mg/kg iv) completely reversed the adverse actions on ulcer healing, gastric blood flow, and angiogenesis in the mucosa at the ulcer margin but partially restored angiogenesis in granulation tissues. In conclusion, cigarette smoke exposure delays ulcer healing through depression of gastric blood flow and angiogenesis at the ulcer margin. Reduction of cNOS expression and activity is suggested to be involved in these ulcerogenic processes.
Persistent Identifierhttp://hdl.handle.net/10722/49276
ISSN
2015 Impact Factor: 3.297
2015 SCImago Journal Rankings: 1.936
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorChow, JYCen_HK
dc.contributor.authorCho, CHen_HK
dc.date.accessioned2008-06-12T06:38:17Z-
dc.date.available2008-06-12T06:38:17Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal of Physiology: Gastrointestinal and Liver Physiology, 1999, v. 276 n. 1, p. G238-G248en_HK
dc.identifier.issn0193-1857en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49276-
dc.description.abstractEpidemiological studies have shown that cigarette smoking is associated with peptic ulceration. This study aims to investigate the mechanisms by which cigarette smoking delays ulcer healing in rats. Gastric ulcers were induced by applying acetic acid to the luminal surfaces in rats. Twenty-four hours later, rats were exposed to different concentrations of cigarette smoke (0, 2, or 4%) for a 1-h period once daily for 3 or 6 days. Cigarette smoke exposure delayed ulcer healing and decreased gastric blood flow and angiogenesis at the ulcer margin. These changes were accompanied by a significant reduction of constitutive nitric oxide synthase (cNOS) activity but not PGE2 production and vascular endothelial growth factor levels. Administration of L-arginine (10 mg/kg iv) completely reversed the adverse actions on ulcer healing, gastric blood flow, and angiogenesis in the mucosa at the ulcer margin but partially restored angiogenesis in granulation tissues. In conclusion, cigarette smoke exposure delays ulcer healing through depression of gastric blood flow and angiogenesis at the ulcer margin. Reduction of cNOS expression and activity is suggested to be involved in these ulcerogenic processes.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://intl-ajpgi.physiology.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectGastric blood flowen_HK
dc.subjectAngiogenesisen_HK
dc.subjectProstaglandin E2en_HK
dc.subjectgastric blooL-arginineen_HK
dc.titleCigarette smoking delays ulcer healing: role of constitutive nitric oxide synthase in rat stomachen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0193-1857&volume=276&issue=1&spage=G238&epage=G248&date=1999&atitle=Cigarette+smoking+delays+ulcer+healing:+role+of+constitutive+nitric+oxide+synthase+in+rat+stomachen_HK
dc.identifier.emailChow, JYC: h9594035@hkusua.hku.hken_HK
dc.identifier.emailCho, CH: chcho@hkusua.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9887001-
dc.identifier.scopuseid_2-s2.0-0345148802-
dc.identifier.hkuros41179-
dc.identifier.isiWOS:000078101300031-

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