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Article: Oxidative modification of low density lipoprotein in normal and hyperlipidemic patients: Effect of lysophosphatidylcholine composition on vascular relaxation

TitleOxidative modification of low density lipoprotein in normal and hyperlipidemic patients: Effect of lysophosphatidylcholine composition on vascular relaxation
Authors
Keywordsendothelium-vascular
hyperlipidemia
LDL- metabolism
lysophosphatidylcholine-metabolism
Issue Date1997
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/
Citation
Journal Of Lipid Research, 1997, v. 38 n. 3, p. 546-553 How to Cite?
AbstractThe elevated level of plasma low density lipoprotein (LDL) in hyperlipidemic patients is an important risk factor for the production of atherosclerosis. Plasma LDL must be modified before it can produce an impairment of endothelium-dependent relaxation in aortic rings or enhancement of uptake by macrophages. The dramatic increase in lysophosphatidylcholine (lysoPC) content in oxidatively modified LDL has been touted as an important biochemical factor for the impairment of endothelium-dependent relaxation. The present study was designed to examine the lysoPC composition of oxidized LDL samples from normal and hyperlipidemic subjects, and their effects on the impairment of endothelium-dependent relaxation. Oxidatively modified LDL from hyperlipidemic patients contained a slightly higher level (17%) of lysoPC, but produced a disproportionately greater impairment of endothelium-dependent relaxation than that from normal subjects. As lysoPC is composed of many molecular species, its composition in oxidized LDL samples was analyzed. In hyperlipidemic patients, lysoPC samples were found to contain a higher proportion of long-chain acyl groups. Subsequent studies revealed that only long-chain lysoPC (C(≤16:0)) were effective in impairing endothelium- dependent relaxation. Experimental loading of oxidized LDL from normal subjects with long chain lysoPC to mimic levels observed in oxidized LDL from hyperlipidemic patients resulted in further impairment of endothelium- dependent relaxation. We conclude that the greater proportion of long-chain lysoPC found in the oxidized LDL of hyperlipidemic subjects is responsible for the increased impairment of endothelium-dependent vascular relaxation. We propose that the high level of LDL found in the plasma of hyperlipidemic patients, coupled with its enhanced ability to generate long chain species of lysoPC during oxidative modification, are important factors for the development of atherosclerosis in these patients.
Persistent Identifierhttp://hdl.handle.net/10722/49273
ISSN
2015 Impact Factor: 4.368
2015 SCImago Journal Rankings: 2.529
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Len_HK
dc.contributor.authorLiang, Ben_HK
dc.contributor.authorFroese, DEen_HK
dc.contributor.authorLiu, Sen_HK
dc.contributor.authorWong, JTen_HK
dc.contributor.authorTran, Ken_HK
dc.contributor.authorHatch, GMen_HK
dc.contributor.authorMymin, Den_HK
dc.contributor.authorKroeger, EAen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorChoy, PCen_HK
dc.date.accessioned2008-06-12T06:38:13Z-
dc.date.available2008-06-12T06:38:13Z-
dc.date.issued1997en_HK
dc.identifier.citationJournal Of Lipid Research, 1997, v. 38 n. 3, p. 546-553en_HK
dc.identifier.issn0022-2275en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49273-
dc.description.abstractThe elevated level of plasma low density lipoprotein (LDL) in hyperlipidemic patients is an important risk factor for the production of atherosclerosis. Plasma LDL must be modified before it can produce an impairment of endothelium-dependent relaxation in aortic rings or enhancement of uptake by macrophages. The dramatic increase in lysophosphatidylcholine (lysoPC) content in oxidatively modified LDL has been touted as an important biochemical factor for the impairment of endothelium-dependent relaxation. The present study was designed to examine the lysoPC composition of oxidized LDL samples from normal and hyperlipidemic subjects, and their effects on the impairment of endothelium-dependent relaxation. Oxidatively modified LDL from hyperlipidemic patients contained a slightly higher level (17%) of lysoPC, but produced a disproportionately greater impairment of endothelium-dependent relaxation than that from normal subjects. As lysoPC is composed of many molecular species, its composition in oxidized LDL samples was analyzed. In hyperlipidemic patients, lysoPC samples were found to contain a higher proportion of long-chain acyl groups. Subsequent studies revealed that only long-chain lysoPC (C(≤16:0)) were effective in impairing endothelium- dependent relaxation. Experimental loading of oxidized LDL from normal subjects with long chain lysoPC to mimic levels observed in oxidized LDL from hyperlipidemic patients resulted in further impairment of endothelium- dependent relaxation. We conclude that the greater proportion of long-chain lysoPC found in the oxidized LDL of hyperlipidemic subjects is responsible for the increased impairment of endothelium-dependent vascular relaxation. We propose that the high level of LDL found in the plasma of hyperlipidemic patients, coupled with its enhanced ability to generate long chain species of lysoPC during oxidative modification, are important factors for the development of atherosclerosis in these patients.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jlr.org/en_HK
dc.relation.ispartofJournal of Lipid Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Lipid Research. Copyright © American Society for Biochemistry and Molecular Biology, Inc.en_HK
dc.subjectendothelium-vascularen_HK
dc.subjecthyperlipidemiaen_HK
dc.subjectLDL- metabolismen_HK
dc.subjectlysophosphatidylcholine-metabolismen_HK
dc.titleOxidative modification of low density lipoprotein in normal and hyperlipidemic patients: Effect of lysophosphatidylcholine composition on vascular relaxationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-2275&volume=38&issue=3&spage=546&epage=553&date=1997&atitle=Oxidative+modification+of+low+density+lipoprotein+in+normal+and+hyperlipidemic+patients:+effect+of+lysophosphatidylcholine+composition+on+vascular+relaxationen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9101435-
dc.identifier.scopuseid_2-s2.0-14444269481en_HK
dc.identifier.hkuros24280-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14444269481&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue3en_HK
dc.identifier.spage546en_HK
dc.identifier.epage553en_HK
dc.identifier.isiWOS:A1997WT52500013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, L=8226605100en_HK
dc.identifier.scopusauthoridLiang, B=7202071094en_HK
dc.identifier.scopusauthoridFroese, DE=6603371268en_HK
dc.identifier.scopusauthoridLiu, S=7409460160en_HK
dc.identifier.scopusauthoridWong, JT=36771977000en_HK
dc.identifier.scopusauthoridTran, K=7102163210en_HK
dc.identifier.scopusauthoridHatch, GM=7102271713en_HK
dc.identifier.scopusauthoridMymin, D=6701628222en_HK
dc.identifier.scopusauthoridKroeger, EA=7003400023en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK
dc.identifier.scopusauthoridChoy, PC=7006633002en_HK

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