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Article: Cytokine profiles in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy.

TitleCytokine profiles in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy.
Authors
Issue Date2005
PublisherWebMD Medscape Health Network. The Journal's web site is located at http://www.medscape.com/pages/editorial/ejournal/public/mgm/about?src=hdr
Citation
Medgenmed [Electronic Resource] : Medscape General Medicine., 2005, v. 7 n. 2, p. 71 How to Cite?
AbstractCONTEXT: There have been few longitudinal studies of cytokine production in neonatally acquired HIV-1 infection and none in Asian or Chinese children. OBJECTIVE: To determine whether monitoring cytokine production could contribute to the better management of pediatric patients with HIV-1 infection. SETTING: Clinical Immunology Laboratory and Pediatrics Department, University Hospital, Hong Kong. PATIENTS: Ten Asian and 2 Eurasian children infected with HIV-1 by mother-to-child transmission were followed for up to 5 years while on treatment with highly active antiretroviral therapy (HAART). MAIN OUTCOME MEASURES: Numbers of unstimulated and mitogen-activated cytokine-secreting cells (IFN-gamma, interleukin [IL]-2, IL-4, IL-6, IL-10, IL-12, and TNF-alpha) were measured by ELISPOT assay at frequent intervals, and correlations were sought with CD4+ and CD8+ cell counts and viral loads. RESULTS: Mitogen-stimulated IL-2-secreting cells were directly associated with recovery of CD4+ cells. Correlations with viral load were found for Con A-induced IFN-gamma, Con A-induced IL-4, and unstimulated IL-10, suggesting that these cytokines were either suppressed by high virus levels or that higher cytokine levels suppressed virus. IFN-gamma, IL-2-, IL-4-, and IL-12-secreting cells induced by PHA, Con A, and/or SAC tended to increase for the first 3-4 years of treatment but declined thereafter. CONCLUSIONS: Alterations in cytokine profiles were not associated with adverse clinical events and there was little evidence to indicate that monitoring cytokine enzyme-linked immunospots (ELISPOTs) could contribute to pediatric patient management.
Persistent Identifierhttp://hdl.handle.net/10722/49270
ISSN
2012 SCImago Journal Rankings: 1.150
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorJones, BMen_HK
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorWong, WHen_HK
dc.contributor.authorLim, WWen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2008-06-12T06:38:06Z-
dc.date.available2008-06-12T06:38:06Z-
dc.date.issued2005en_HK
dc.identifier.citationMedgenmed [Electronic Resource] : Medscape General Medicine., 2005, v. 7 n. 2, p. 71en_HK
dc.identifier.issn1531-0132en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49270-
dc.description.abstractCONTEXT: There have been few longitudinal studies of cytokine production in neonatally acquired HIV-1 infection and none in Asian or Chinese children. OBJECTIVE: To determine whether monitoring cytokine production could contribute to the better management of pediatric patients with HIV-1 infection. SETTING: Clinical Immunology Laboratory and Pediatrics Department, University Hospital, Hong Kong. PATIENTS: Ten Asian and 2 Eurasian children infected with HIV-1 by mother-to-child transmission were followed for up to 5 years while on treatment with highly active antiretroviral therapy (HAART). MAIN OUTCOME MEASURES: Numbers of unstimulated and mitogen-activated cytokine-secreting cells (IFN-gamma, interleukin [IL]-2, IL-4, IL-6, IL-10, IL-12, and TNF-alpha) were measured by ELISPOT assay at frequent intervals, and correlations were sought with CD4+ and CD8+ cell counts and viral loads. RESULTS: Mitogen-stimulated IL-2-secreting cells were directly associated with recovery of CD4+ cells. Correlations with viral load were found for Con A-induced IFN-gamma, Con A-induced IL-4, and unstimulated IL-10, suggesting that these cytokines were either suppressed by high virus levels or that higher cytokine levels suppressed virus. IFN-gamma, IL-2-, IL-4-, and IL-12-secreting cells induced by PHA, Con A, and/or SAC tended to increase for the first 3-4 years of treatment but declined thereafter. CONCLUSIONS: Alterations in cytokine profiles were not associated with adverse clinical events and there was little evidence to indicate that monitoring cytokine enzyme-linked immunospots (ELISPOTs) could contribute to pediatric patient management.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherWebMD Medscape Health Network. The Journal's web site is located at http://www.medscape.com/pages/editorial/ejournal/public/mgm/about?src=hdren_HK
dc.relation.ispartofMedGenMed [electronic resource] : Medscape general medicine.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnti-Retroviral Agents - therapeutic useen_HK
dc.subject.meshAntiretroviral Therapy, Highly Active - methods - trendsen_HK
dc.subject.meshCytokines - blooden_HK
dc.subject.meshDideoxynucleosides - therapeutic useen_HK
dc.subject.meshHIV Infections - blood - drug therapyen_HK
dc.titleCytokine profiles in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1531-0132&volume=7&issue=2&spage=71&epage=&date=2005&atitle=Cytokine+profiles+in+human+immunodeficiency+viurs-infected+children+treated+with+highly+active+antiretroviral+therapyen_HK
dc.identifier.emailChiu, SS:ssschiu@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid16369449en_HK
dc.identifier.pmcidPMC1681548en_HK
dc.identifier.scopuseid_2-s2.0-25144434906en_HK
dc.identifier.hkuros97910-
dc.identifier.volume7en_HK
dc.identifier.issue2en_HK
dc.identifier.spage71en_HK
dc.identifier.epage71en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJones, BM=7404958958en_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridWong, WH=13310222200en_HK
dc.identifier.scopusauthoridLim, WW=7202378267en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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