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Article: Sex difference in immunostaining of RET in the adult mouse kidney

TitleSex difference in immunostaining of RET in the adult mouse kidney
Authors
Keywordsc-ret
Kidney
RET
Issue Date1998
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 1998, v. 17 n. 5, p. 661-666 How to Cite?
AbstractThe c-ret proto-oncogene encodes a receptor tyrosine kinase which is important for the development of the kidney and the enteric nervous system. During nephrogenesis, c-ret is expressed in the ureteric bud epithelium and later in its derivative, the collecting duct. This takes place during 11-17.5 days post-coitum (d.p.c.) in the mouse and our immunohistochemical study showed that the RET protein co-localized with the transcript. At 18.5 d.p.c. the kidney is fully differentiated. At 18.5 d.p.c., 1 week and 10 weeks old, RET was found in the proximal convoluted tubules, which is formed from the condensed mesenchyme. This suggests that c-ret may also play a role in kidney function. For the 10 weeks old kidney, RET immunostaining in male was concentrated on the basolateral side while female had a stronger staining in the whole cell. Furthermore, cytoplasmic staining was observed in male whereas both cytoplasmic and nuclear staining was found in female. c-ret transcript was detected by RT-PCR, and in situ hybridization showed its expression throughout the kidney. The reason for the sex-specific staining and the role of RET in kidney function remain to be determined.
Persistent Identifierhttp://hdl.handle.net/10722/49266
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, SYen_HK
dc.contributor.authorLee, DCWen_HK
dc.date.accessioned2008-06-12T06:38:01Z-
dc.date.available2008-06-12T06:38:01Z-
dc.date.issued1998en_HK
dc.identifier.citationOncogene, 1998, v. 17 n. 5, p. 661-666en_HK
dc.identifier.issn0950-9232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49266-
dc.description.abstractThe c-ret proto-oncogene encodes a receptor tyrosine kinase which is important for the development of the kidney and the enteric nervous system. During nephrogenesis, c-ret is expressed in the ureteric bud epithelium and later in its derivative, the collecting duct. This takes place during 11-17.5 days post-coitum (d.p.c.) in the mouse and our immunohistochemical study showed that the RET protein co-localized with the transcript. At 18.5 d.p.c. the kidney is fully differentiated. At 18.5 d.p.c., 1 week and 10 weeks old, RET was found in the proximal convoluted tubules, which is formed from the condensed mesenchyme. This suggests that c-ret may also play a role in kidney function. For the 10 weeks old kidney, RET immunostaining in male was concentrated on the basolateral side while female had a stronger staining in the whole cell. Furthermore, cytoplasmic staining was observed in male whereas both cytoplasmic and nuclear staining was found in female. c-ret transcript was detected by RT-PCR, and in situ hybridization showed its expression throughout the kidney. The reason for the sex-specific staining and the role of RET in kidney function remain to be determined.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_HK
dc.relation.ispartofOncogeneen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectc-reten_HK
dc.subjectKidneyen_HK
dc.subjectRETen_HK
dc.titleSex difference in immunostaining of RET in the adult mouse kidneyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9232&volume=17&issue=5&spage=661&epage=666&date=1998&atitle=Sex+difference+in+immunostaining+of+RET+in+the+adult+mouse+kidneyen_HK
dc.identifier.emailChan, SY:sychan@hkucc.hku.hken_HK
dc.identifier.authorityChan, SY=rp00356en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1038/sj.onc.1201970en_HK
dc.identifier.pmid9704933-
dc.identifier.scopuseid_2-s2.0-0032490839en_HK
dc.identifier.hkuros38777-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032490839&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue5en_HK
dc.identifier.spage661en_HK
dc.identifier.epage666en_HK
dc.identifier.isiWOS:000075195300015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, SY=7404255082en_HK
dc.identifier.scopusauthoridLee, DCW=7406663288en_HK

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