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Article: Continuing evolution of H9N2 influenza viruses in Southeastern China

TitleContinuing evolution of H9N2 influenza viruses in Southeastern China
Authors
Issue Date2004
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2004, v. 78 n. 16, p. 8609-8614 How to Cite?
AbstractH9N2 influenza viruses are panzootic in domestic poultry in Eurasia and since 1999 have caused transient infections in humans and pigs. To investigate the zoonotic potential of H9N2 viruses, we studied the evolution of the viruses in live-poultry markets in Hong Kong in 2003. H9N2 was the most prevalent influenza virus subtype in the live-poultry markets between 2001 and 2003. Antigenic and phylogenetic analysis of hemagglutinin (HA) showed that all of the 19 isolates found except one belonged to the lineage represented by A/Duck/Hong Kong/Y280/97 (H9N2). The exception was A/Guinea fowl/NT184/03 (H9N2), whose HA is most closely related to that of the human isolate A/Guangzhou/333/99 (H9N2), a virus belonging to the A/Chicken/ Beijing/1/94-like (H9N2) lineage. At least six different genotypes were recognized. The majority of the viruses had nonstructural (and HA) genes derived from the A/Duck/Hong Kong/Y280/97-like virus lineage but had other genes of mixed avian virus origin, including genes similar to those of H5N1 viruses isolated in 2001. Viruses of all six genotypes of H9N2 found were able to replicate in chickens and mice without adaptation. The infected chickens showed no signs of disease, but representatives of two viral genotypes were lethal to mice. Three genotypes of virus replicated in the respiratory tracts of swine, which shed virus for at least 5 days. These results show an increasing genetic and biologic diversity of H9N2 viruses in Hong Kong and support their potential role as pandemic influenza agents.
Persistent Identifierhttp://hdl.handle.net/10722/49258
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChoi, YKen_HK
dc.contributor.authorOzaki, Hen_HK
dc.contributor.authorWebby, RJen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorPeiris, JSen_HK
dc.contributor.authorPoon, Len_HK
dc.contributor.authorButt, Cen_HK
dc.contributor.authorLeung, YHCen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2008-06-12T06:37:45Z-
dc.date.available2008-06-12T06:37:45Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Virology, 2004, v. 78 n. 16, p. 8609-8614en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49258-
dc.description.abstractH9N2 influenza viruses are panzootic in domestic poultry in Eurasia and since 1999 have caused transient infections in humans and pigs. To investigate the zoonotic potential of H9N2 viruses, we studied the evolution of the viruses in live-poultry markets in Hong Kong in 2003. H9N2 was the most prevalent influenza virus subtype in the live-poultry markets between 2001 and 2003. Antigenic and phylogenetic analysis of hemagglutinin (HA) showed that all of the 19 isolates found except one belonged to the lineage represented by A/Duck/Hong Kong/Y280/97 (H9N2). The exception was A/Guinea fowl/NT184/03 (H9N2), whose HA is most closely related to that of the human isolate A/Guangzhou/333/99 (H9N2), a virus belonging to the A/Chicken/ Beijing/1/94-like (H9N2) lineage. At least six different genotypes were recognized. The majority of the viruses had nonstructural (and HA) genes derived from the A/Duck/Hong Kong/Y280/97-like virus lineage but had other genes of mixed avian virus origin, including genes similar to those of H5N1 viruses isolated in 2001. Viruses of all six genotypes of H9N2 found were able to replicate in chickens and mice without adaptation. The infected chickens showed no signs of disease, but representatives of two viral genotypes were lethal to mice. Three genotypes of virus replicated in the respiratory tracts of swine, which shed virus for at least 5 days. These results show an increasing genetic and biologic diversity of H9N2 viruses in Hong Kong and support their potential role as pandemic influenza agents.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of virology, 2004, v. 78 n. 16, p. 8609-8614en_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshInfluenza A Virus, H9N2 Subtypeen_HK
dc.subject.meshInfluenza A virus - classification - genetics - growth & development - isolation &en_HK
dc.subject.meshPoultry - virologyen_HK
dc.subject.meshSwine - virologyen_HK
dc.titleContinuing evolution of H9N2 influenza viruses in Southeastern Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=78&issue=16&spage=8609&epage=8614&date=2004&atitle=Continuing+evolution+of+H9N2+influenza+viruses+in+southeastern+Chinaen_HK
dc.identifier.emailPeiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailPoon, L: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailLeung, YHC: cyhleung@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, JS=rp00410en_HK
dc.identifier.authorityPoon, L=rp00484en_HK
dc.identifier.authorityLeung, YHC=rp00307en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.78.16.8609-8614.2004en_HK
dc.identifier.pmid15280470en_HK
dc.identifier.pmcidPMC479067en_HK
dc.identifier.scopuseid_2-s2.0-3543124660en_HK
dc.identifier.hkuros94970-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3543124660&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue16en_HK
dc.identifier.spage8609en_HK
dc.identifier.epage8614en_HK
dc.identifier.isiWOS:000223046000021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChoi, YK=7404776658en_HK
dc.identifier.scopusauthoridOzaki, H=7201753697en_HK
dc.identifier.scopusauthoridWebby, RJ=35448064800en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridPeiris, JS=7005486823en_HK
dc.identifier.scopusauthoridPoon, L=7005441747en_HK
dc.identifier.scopusauthoridButt, C=7006696825en_HK
dc.identifier.scopusauthoridLeung, YHC=26531438300en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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