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Article: Reemerging H5N1 Influenza Viruses in Hong Kong in 2002 Are Highly Pathogenic to Ducks

TitleReemerging H5N1 Influenza Viruses in Hong Kong in 2002 Are Highly Pathogenic to Ducks
Authors
Issue Date2004
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2004, v. 78 n. 9, p. 4892-4901 How to Cite?
AbstractWaterfowl are the natural reservoir of all influenza A viruses, which are usually nonpathogenic in wild aquatic birds. However, in late 2002, outbreaks of highly pathogenic H5N1 influenza virus caused deaths among wild migratory birds and resident waterfowl, including ducks, in two Hong Kong parks. In February 2003, an avian H5N1 virus closely related to one of these viruses was isolated from two humans with acute respiratory distress, one of whom died. Antigenic analysis of the new avian isolates showed a reactivity pattern different from that of H5N1 viruses isolated in 1997 and 2001. This finding suggests that significant antigenic variation has recently occurred among H5N1 viruses. We inoculated mallards with antigenically different H5N1 influenza viruses isolated between 1997 and 2003. The new 2002 avian isolates caused systemic infection in the ducks, with high virus titers and pathology in multiple organs, particularly the brain. Ducks developed acute disease, including severe neurological dysfunction and death. Virus was also isolated at high titers from the birds' drinking water and from contact birds, demonstrating efficient transmission. In contrast, H5N1 isolates from 1997 and 2001 were not consistently transmitted efficiently among ducks and did not cause significant disease. Despite a high level of genomic homology, the human isolate showed striking biological differences from its avian homologue in a duck model. This is the first reported case of lethal influenza virus infection in wild aquatic birds since 1961.
Persistent Identifierhttp://hdl.handle.net/10722/49239
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSturmRamirez, KMen_HK
dc.contributor.authorEllis, Ten_HK
dc.contributor.authorBousfield, Ben_HK
dc.contributor.authorBissett, Len_HK
dc.contributor.authorDyrting, Ken_HK
dc.contributor.authorRehg, JEen_HK
dc.contributor.authorPoon, Len_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorWebster, RGen_HK
dc.date.accessioned2008-06-12T06:37:22Z-
dc.date.available2008-06-12T06:37:22Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Virology, 2004, v. 78 n. 9, p. 4892-4901en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49239-
dc.description.abstractWaterfowl are the natural reservoir of all influenza A viruses, which are usually nonpathogenic in wild aquatic birds. However, in late 2002, outbreaks of highly pathogenic H5N1 influenza virus caused deaths among wild migratory birds and resident waterfowl, including ducks, in two Hong Kong parks. In February 2003, an avian H5N1 virus closely related to one of these viruses was isolated from two humans with acute respiratory distress, one of whom died. Antigenic analysis of the new avian isolates showed a reactivity pattern different from that of H5N1 viruses isolated in 1997 and 2001. This finding suggests that significant antigenic variation has recently occurred among H5N1 viruses. We inoculated mallards with antigenically different H5N1 influenza viruses isolated between 1997 and 2003. The new 2002 avian isolates caused systemic infection in the ducks, with high virus titers and pathology in multiple organs, particularly the brain. Ducks developed acute disease, including severe neurological dysfunction and death. Virus was also isolated at high titers from the birds' drinking water and from contact birds, demonstrating efficient transmission. In contrast, H5N1 isolates from 1997 and 2001 were not consistently transmitted efficiently among ducks and did not cause significant disease. Despite a high level of genomic homology, the human isolate showed striking biological differences from its avian homologue in a duck model. This is the first reported case of lethal influenza virus infection in wild aquatic birds since 1961.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2004, v. 78 n. 9, p. 4892-4901en_HK
dc.subject.meshBird Diseases - physiopathology - transmission - virologyen_HK
dc.subject.meshCommunicable Diseases, Emerging - mortality - transmission - virologyen_HK
dc.subject.meshDucks - virologyen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshInfluenza A virus - classification - isolation & purification - pathogenicityen_HK
dc.titleReemerging H5N1 Influenza Viruses in Hong Kong in 2002 Are Highly Pathogenic to Ducksen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=78&issue=9&spage=4892&epage=4901&date=2004&atitle=Reemerging+H5N1+influenza+viruses+in+Hong+Kong+in+2002+are+highly+pathogenic+to+ducksen_HK
dc.identifier.emailPoon, L: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityPoon, L=rp00484en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.78.9.4892-4901.2004en_HK
dc.identifier.pmid15078970-
dc.identifier.pmcidPMC387679en_HK
dc.identifier.scopuseid_2-s2.0-2542545140en_HK
dc.identifier.hkuros87594-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2542545140&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue9en_HK
dc.identifier.spage4892en_HK
dc.identifier.epage4901en_HK
dc.identifier.isiWOS:000220880200052-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSturmRamirez, KM=6507645950en_HK
dc.identifier.scopusauthoridEllis, T=7202589926en_HK
dc.identifier.scopusauthoridBousfield, B=8325587600en_HK
dc.identifier.scopusauthoridBissett, L=6602749538en_HK
dc.identifier.scopusauthoridDyrting, K=6508235969en_HK
dc.identifier.scopusauthoridRehg, JE=7004835777en_HK
dc.identifier.scopusauthoridPoon, L=7005441747en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK

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