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Article: Epidemiologic analysis of invasive and noninvasive group A streptococcal isolates in Hong Kong

TitleEpidemiologic analysis of invasive and noninvasive group A streptococcal isolates in Hong Kong
Authors
Issue Date2003
PublisherAmerican Society for Microbiology.
Citation
Journal Of Clinical Microbiology, 2003, v. 41 n. 3, p. 937-942 How to Cite?
AbstractSince the mid-1980s, there has been a resurgence of severe forms of invasive group A streptococcal (GAS) disease in many Western countries. In Hong Kong, a similar increase has also been observed in recent years. One hundred seven GAS isolates collected from 1995 to 1998 from individuals with necrotizing fasciitis, toxic shock syndrome, meningitis, or other type of bacteremic sepsis (invasive group, n = 24) as well as from individuals with minor skin and throat infections (noninvasive group, n = 83) were characterized through serologic and/or emm sequence typing. Thirty-two M protein gene sequence types were identified. Types M1, M4, and M12 were the most prevalent in both the invasive group and the noninvasive group; together they accounted for 70.8 and 37.3% of the isolates, respectively. No clear pattern of skin and throat infection M types was observed. Type M1 was overrepresented in the invasive and pharyngeal isolates. The same pulsed-field gel electrophoresis pattern was shared by most invasive and all pharyngeal M1 isolates. Overall, resistance to erythromycin (32%) and tetracycline (53%) was high, but M1 isolates were significantly less likely to have resistance to either antimicrobial agent than non-M1 isolates. One novel emm sequence type, stHK, was identified in an isolate from a patient with necrotizing fasciitis. Minor emm gene sequence alterations were noted for 31 isolates, and for 13 of these isolates, deletion, insertion, or point mutations were seen in the hypervariable 50 N-terminal residues.
Persistent Identifierhttp://hdl.handle.net/10722/49236
ISSN
2015 Impact Factor: 3.631
2015 SCImago Journal Rankings: 2.151
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorJohnson, DRen_HK
dc.contributor.authorYue, AWYen_HK
dc.contributor.authorTsang, DNCen_HK
dc.contributor.authorQue, TLen_HK
dc.contributor.authorBeall, Ben_HK
dc.contributor.authorKaplan, ELen_HK
dc.date.accessioned2008-06-12T06:37:18Z-
dc.date.available2008-06-12T06:37:18Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Clinical Microbiology, 2003, v. 41 n. 3, p. 937-942en_HK
dc.identifier.issn0095-1137en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49236-
dc.description.abstractSince the mid-1980s, there has been a resurgence of severe forms of invasive group A streptococcal (GAS) disease in many Western countries. In Hong Kong, a similar increase has also been observed in recent years. One hundred seven GAS isolates collected from 1995 to 1998 from individuals with necrotizing fasciitis, toxic shock syndrome, meningitis, or other type of bacteremic sepsis (invasive group, n = 24) as well as from individuals with minor skin and throat infections (noninvasive group, n = 83) were characterized through serologic and/or emm sequence typing. Thirty-two M protein gene sequence types were identified. Types M1, M4, and M12 were the most prevalent in both the invasive group and the noninvasive group; together they accounted for 70.8 and 37.3% of the isolates, respectively. No clear pattern of skin and throat infection M types was observed. Type M1 was overrepresented in the invasive and pharyngeal isolates. The same pulsed-field gel electrophoresis pattern was shared by most invasive and all pharyngeal M1 isolates. Overall, resistance to erythromycin (32%) and tetracycline (53%) was high, but M1 isolates were significantly less likely to have resistance to either antimicrobial agent than non-M1 isolates. One novel emm sequence type, stHK, was identified in an isolate from a patient with necrotizing fasciitis. Minor emm gene sequence alterations were noted for 31 isolates, and for 13 of these isolates, deletion, insertion, or point mutations were seen in the hypervariable 50 N-terminal residues.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofJournal of Clinical Microbiologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Clinical Microbiology, 2003, v. 41 n. 3, p. 937-942en_HK
dc.subject.meshAntigens, Bacterialen_HK
dc.subject.meshStreptococcal Infections - epidemiology - microbiologyen_HK
dc.subject.meshStreptococcus pyogenes - classification - drug effects - isolation & purificationen_HK
dc.subject.meshAmino Acid Sequenceen_HK
dc.subject.meshAnti-Bacterial Agents - pharmacologyen_HK
dc.titleEpidemiologic analysis of invasive and noninvasive group A streptococcal isolates in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0095-1137&volume=41&issue=3&spage=937&epage=942&date=2003&atitle=Epidemiologic+analysis+of+invasive+and+noninvasive+group+A+streptococcal+isolates+in+Hong+Kongen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JCM.41.3.937-942.2003en_HK
dc.identifier.pmid12624012-
dc.identifier.pmcidPMC150310en_HK
dc.identifier.scopuseid_2-s2.0-0344837911en_HK
dc.identifier.hkuros87333-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344837911&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue3en_HK
dc.identifier.spage937en_HK
dc.identifier.epage942en_HK
dc.identifier.isiWOS:000181616500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridJohnson, DR=35350740500en_HK
dc.identifier.scopusauthoridYue, AWY=7003982472en_HK
dc.identifier.scopusauthoridTsang, DNC=7005609132en_HK
dc.identifier.scopusauthoridQue, TL=7003786628en_HK
dc.identifier.scopusauthoridBeall, B=7006753048en_HK
dc.identifier.scopusauthoridKaplan, EL=35402586700en_HK

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