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Article: Role of quail in the interspecies transmission of H9 influenza a viruses: Molecular changes on HA that correspond to adaptation from ducks to chickens

TitleRole of quail in the interspecies transmission of H9 influenza a viruses: Molecular changes on HA that correspond to adaptation from ducks to chickens
Authors
Issue Date2003
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2003, v. 77 n. 5, p. 3148-3156 How to Cite?
AbstractH9 influenza viruses have become endemic in land-based domestic poultry in Asia and have sporadically crossed to pigs and humans. To understand the molecular determinants of their adaptation to land-based birds, we tested the replication and transmission of several 1970s duck H9 viruses in chickens and quail. Quail were more susceptible than chickens to these viruses, and generation of recombinant H9 viruses by reverse genetics showed that changes in the HA gene are sufficient to initiate efficient replication and transmission in quail. Seven amino acid positions on the HA molecule corresponded to adaptation to land-based birds. In quail H9 viruses, the pattern of amino acids at these seven positions is intermediate between those of duck and chicken viruses; this fact may explain the susceptibility of quail to duck H9 viruses. Our findings suggest that quail provide an environment in which the adaptation of influenza viruses from ducks generates novel variants that can cross the species barrier.
Persistent Identifierhttp://hdl.handle.net/10722/49235
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPerez, DRen_HK
dc.contributor.authorLim, Wen_HK
dc.contributor.authorSeiler, JPen_HK
dc.contributor.authorYi, Gen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorWebster, RGen_HK
dc.date.accessioned2008-06-12T06:37:17Z-
dc.date.available2008-06-12T06:37:17Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Virology, 2003, v. 77 n. 5, p. 3148-3156en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49235-
dc.description.abstractH9 influenza viruses have become endemic in land-based domestic poultry in Asia and have sporadically crossed to pigs and humans. To understand the molecular determinants of their adaptation to land-based birds, we tested the replication and transmission of several 1970s duck H9 viruses in chickens and quail. Quail were more susceptible than chickens to these viruses, and generation of recombinant H9 viruses by reverse genetics showed that changes in the HA gene are sufficient to initiate efficient replication and transmission in quail. Seven amino acid positions on the HA molecule corresponded to adaptation to land-based birds. In quail H9 viruses, the pattern of amino acids at these seven positions is intermediate between those of duck and chicken viruses; this fact may explain the susceptibility of quail to duck H9 viruses. Our findings suggest that quail provide an environment in which the adaptation of influenza viruses from ducks generates novel variants that can cross the species barrier.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2003, v. 77 n. 5, p. 3148-3156en_HK
dc.subject.meshAdaptation, Physiologicalen_HK
dc.subject.meshBird Diseases - transmission - virologyen_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshInfluenza A virus - genetics - physiologyen_HK
dc.subject.meshQuail - virologyen_HK
dc.titleRole of quail in the interspecies transmission of H9 influenza a viruses: Molecular changes on HA that correspond to adaptation from ducks to chickensen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=77&issue=5&spage=3148&epage=3156&date=2003&atitle=Role+of+quail+in+the+interspecies+transmission+of+H9+influenza+A+viruses:+molecular+changes+on+HA+that+correspond+to+adaptation+from+ducks+to+chickensen_HK
dc.identifier.emailYi, G: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityYi, G=rp00397en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.77.5.3148-3156.2003en_HK
dc.identifier.pmid12584339-
dc.identifier.pmcidPMC149770en_HK
dc.identifier.scopuseid_2-s2.0-0037372071en_HK
dc.identifier.hkuros83271-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037372071&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue5en_HK
dc.identifier.spage3148en_HK
dc.identifier.epage3156en_HK
dc.identifier.isiWOS:000180999700037-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPerez, DR=7101996480en_HK
dc.identifier.scopusauthoridLim, W=7202378277en_HK
dc.identifier.scopusauthoridSeiler, JP=36342907100en_HK
dc.identifier.scopusauthoridYi, G=7202924055en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK

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