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Article: Neurovirulence in mice of H5N1 influenza virus genotypes isolated from Hong Kong poultry in 2001

TitleNeurovirulence in mice of H5N1 influenza virus genotypes isolated from Hong Kong poultry in 2001
Authors
Issue Date2003
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2003, v. 77 n. 6, p. 3816-3823 How to Cite?
AbstractWe studied the pathogenicity of five different genotypes (A to E) of highly pathogenic avian H5N1 viruses, which contained HA genes similar to those of the H5N1 virus A/goose/Guangdong/1/96 and five different combinations of "internal" genes, in a mouse model. Highly pathogenic, neurotropic variants of genotypes A, C, D, and E were isolated from the brain after a single intranasal passage in mice. Genotype B virus was isolated from lungs only. The mouse brain variants had amino acid changes in all gene products except PB1, NP, and NS1 proteins but no common sets of mutations. We conclude that the original H5N1/01 isolates of genotypes A, C, D, and E were heterogeneous and that highly pathogenic neurotropic variants can be rapidly selected in mice.
Persistent Identifierhttp://hdl.handle.net/10722/49234
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLipatov, ASen_HK
dc.contributor.authorKrauss, Sen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorRehg, JEen_HK
dc.contributor.authorPerez, DRen_HK
dc.contributor.authorWebster, RGen_HK
dc.date.accessioned2008-06-12T06:37:16Z-
dc.date.available2008-06-12T06:37:16Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Virology, 2003, v. 77 n. 6, p. 3816-3823en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49234-
dc.description.abstractWe studied the pathogenicity of five different genotypes (A to E) of highly pathogenic avian H5N1 viruses, which contained HA genes similar to those of the H5N1 virus A/goose/Guangdong/1/96 and five different combinations of "internal" genes, in a mouse model. Highly pathogenic, neurotropic variants of genotypes A, C, D, and E were isolated from the brain after a single intranasal passage in mice. Genotype B virus was isolated from lungs only. The mouse brain variants had amino acid changes in all gene products except PB1, NP, and NS1 proteins but no common sets of mutations. We conclude that the original H5N1/01 isolates of genotypes A, C, D, and E were heterogeneous and that highly pathogenic neurotropic variants can be rapidly selected in mice.en_HK
dc.format.extent392 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2003, v. 77 n. 6, p. 3816-3823en_HK
dc.subject.meshCentral Nervous System Viral Diseases - pathology - physiopathology - virologyen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshInfluenza A virus - chemistry - classification - genetics - pathogenicityen_HK
dc.subject.meshPoultry Diseases - virologyen_HK
dc.subject.meshInfluenza in Birds - virologyen_HK
dc.titleNeurovirulence in mice of H5N1 influenza virus genotypes isolated from Hong Kong poultry in 2001en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=77&issue=6&spage=3816&epage=3823&date=2003&atitle=Neurovirulence+in+mice+of+H5N1+influenza+virus+genotypes+isolated+from+Hong+Kong+poultry+in+2001en_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.77.6.3816-3823.2003en_HK
dc.identifier.pmid12610156-
dc.identifier.pmcidPMC149508en_HK
dc.identifier.scopuseid_2-s2.0-0037334413en_HK
dc.identifier.hkuros83265-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037334413&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue6en_HK
dc.identifier.spage3816en_HK
dc.identifier.epage3823en_HK
dc.identifier.isiWOS:000181370300047-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLipatov, AS=7005117347en_HK
dc.identifier.scopusauthoridKrauss, S=7102769210en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridRehg, JE=7004835777en_HK
dc.identifier.scopusauthoridPerez, DR=7101996480en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK

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