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Article: Characterization of H9 subtype influenza viruses from the ducks of Southern China: A candidate for the next influenza pandemic in humans?

TitleCharacterization of H9 subtype influenza viruses from the ducks of Southern China: A candidate for the next influenza pandemic in humans?
Authors
Issue Date2003
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2003, v. 77 n. 12, p. 6988-6994 How to Cite?
AbstractA current view of the emergence of pandemic influenza viruses envisages a gene flow from the aquatic avian reservoir to humans via reassortment in pigs, the hypothetical "mixing vessel." Understanding arising from recent H5N1 influenza outbreaks in Hong Kong since 1997 and the isolation of avian H9N2 virus from humans raises alternative options for the emergence of a new pandemic virus. Here we report that H9N2 influenza viruses established in terrestrial poultry in southern China are transmitted back to domestic ducks, in which the viruses generate multiple reassortants. These novel H9N2 viruses are double or even triple reassortants that have amino acid signatures in their hemagglutinin, indicating their potential to directly infect humans. Some of them contain gene segments that are closely related to those of A/Hong Kong/156/97 (H5N1/97, H5N1) or A/Quail/Hong Kong/G1/97 (G1-like, H9N2). More importantly, some of their internal genes are closely related to those of novel H5N1 viruses isolated during the outbreak in Hong Kong in 2001. This study reveals a two-way transmission of influenza virus between terrestrial and aquatic birds that facilitates the generation of novel reassortant H9N2 influenza viruses. Such reassortants may directly or indirectly play a role in the emergence of the next pandemic virus.
Persistent Identifierhttp://hdl.handle.net/10722/49233
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, KSen_HK
dc.contributor.authorXu, KMen_HK
dc.contributor.authorPeiris, SMen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorYu, KZen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorGuan, Yen_HK
dc.date.accessioned2008-06-12T06:37:15Z-
dc.date.available2008-06-12T06:37:15Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Virology, 2003, v. 77 n. 12, p. 6988-6994en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49233-
dc.description.abstractA current view of the emergence of pandemic influenza viruses envisages a gene flow from the aquatic avian reservoir to humans via reassortment in pigs, the hypothetical "mixing vessel." Understanding arising from recent H5N1 influenza outbreaks in Hong Kong since 1997 and the isolation of avian H9N2 virus from humans raises alternative options for the emergence of a new pandemic virus. Here we report that H9N2 influenza viruses established in terrestrial poultry in southern China are transmitted back to domestic ducks, in which the viruses generate multiple reassortants. These novel H9N2 viruses are double or even triple reassortants that have amino acid signatures in their hemagglutinin, indicating their potential to directly infect humans. Some of them contain gene segments that are closely related to those of A/Hong Kong/156/97 (H5N1/97, H5N1) or A/Quail/Hong Kong/G1/97 (G1-like, H9N2). More importantly, some of their internal genes are closely related to those of novel H5N1 viruses isolated during the outbreak in Hong Kong in 2001. This study reveals a two-way transmission of influenza virus between terrestrial and aquatic birds that facilitates the generation of novel reassortant H9N2 influenza viruses. Such reassortants may directly or indirectly play a role in the emergence of the next pandemic virus.en_HK
dc.format.extent392 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2003, v. 77 n. 12, p. 6988-6994en_HK
dc.subject.meshCommunicable Diseases, Emerging - epidemiology - virologyen_HK
dc.subject.meshDisease Outbreaksen_HK
dc.subject.meshDucks - virologyen_HK
dc.subject.meshInfluenza A virus - classification - genetics - pathogenicityen_HK
dc.subject.meshInfluenza, Human - epidemiology - virologyen_HK
dc.titleCharacterization of H9 subtype influenza viruses from the ducks of Southern China: A candidate for the next influenza pandemic in humans?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=77&issue=12&spage=6988&epage=6994&date=2003&atitle=Characterization+of+H9+subtype+influenza+viruses+from+the+ducks+of+southern+China:+a+candidate+for+the+next+influenza+pandemic+in+humans?en_HK
dc.identifier.emailPeiris, SM: malik@hkucc.hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, SM=rp00410en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.77.12.6988-6994.2003en_HK
dc.identifier.pmid12768017-
dc.identifier.pmcidPMC156195en_HK
dc.identifier.scopuseid_2-s2.0-0037942585en_HK
dc.identifier.hkuros83178-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037942585&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue12en_HK
dc.identifier.spage6988en_HK
dc.identifier.epage6994en_HK
dc.identifier.isiWOS:000183209400039-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001013715-
dc.identifier.scopusauthoridLi, KS=36072420200en_HK
dc.identifier.scopusauthoridXu, KM=35228266300en_HK
dc.identifier.scopusauthoridPeiris, SM=7005486823en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridYu, KZ=8934249200en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK

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