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Article: Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR

TitleEmergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR
Authors
Issue Date2002
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2002, v. 99 n. 13, p. 8950-8955 How to Cite?
AbstractAlthough A/Hong Kong/156/97 (H5N1/97)-like viruses associated with the "bird flu" incident in Hong Kong SAR have not been detected since the slaughter of poultry in 1997, its putative precursors continue to persist in the region. One of these, Goose/Guangdong/1/96 (H5N1 Gs/Gd)-like viruses, reassorted with other avian viruses to generate multiple genotypes of H5N1 viruses that crossed to chickens and other terrestrial poultry from its reservoir in geese. Whereas none of these recent reassortants had acquired the gene constellation of H5N1/97, events provide insight into how such a virus may have been generated. The recent H5N1 reassortants readily infect and kill chicken and quail after experimental infection, and some were associated with significant mortality of chickens within the poultry retail markets in Hong Kong. Some genotypes are lethal for mice after intra-nasal inoculation and spread to the brain. On this occasion, the early detection of H5N1 viruses in the retail, live poultry markets led to preemptive intervention before the occurrence of human disease, but these newly emerging, highly pathogenic H5N1 viruses provide cause for pandemic concern.
Persistent Identifierhttp://hdl.handle.net/10722/49219
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.contributor.authorLipatov, ASen_HK
dc.contributor.authorEllis, TMen_HK
dc.contributor.authorDyrting, KCen_HK
dc.contributor.authorKrauss, Sen_HK
dc.contributor.authorZhang, LJen_HK
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorShortridge, KFen_HK
dc.date.accessioned2008-06-12T06:36:59Z-
dc.date.available2008-06-12T06:36:59Z-
dc.date.issued2002en_HK
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2002, v. 99 n. 13, p. 8950-8955en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49219-
dc.description.abstractAlthough A/Hong Kong/156/97 (H5N1/97)-like viruses associated with the "bird flu" incident in Hong Kong SAR have not been detected since the slaughter of poultry in 1997, its putative precursors continue to persist in the region. One of these, Goose/Guangdong/1/96 (H5N1 Gs/Gd)-like viruses, reassorted with other avian viruses to generate multiple genotypes of H5N1 viruses that crossed to chickens and other terrestrial poultry from its reservoir in geese. Whereas none of these recent reassortants had acquired the gene constellation of H5N1/97, events provide insight into how such a virus may have been generated. The recent H5N1 reassortants readily infect and kill chicken and quail after experimental infection, and some were associated with significant mortality of chickens within the poultry retail markets in Hong Kong. Some genotypes are lethal for mice after intra-nasal inoculation and spread to the brain. On this occasion, the early detection of H5N1 viruses in the retail, live poultry markets led to preemptive intervention before the occurrence of human disease, but these newly emerging, highly pathogenic H5N1 viruses provide cause for pandemic concern.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.rightsNational Academy of Sciences Proceedings. Copyright © National Academy of Sciences.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshInfluenza A virus - classification - genetics - immunology - pathogenicityen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.subject.meshPhylogenyen_HK
dc.subject.meshSpecies Specificityen_HK
dc.titleEmergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SARen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=99&issue=13&spage=8950&epage=8955&date=2002&atitle=Emergence+of+multiple+genotypes+of+H5N1+avian+influenza+viruses+in+Hong+Kong+SARen_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1073/pnas.132268999en_HK
dc.identifier.pmid12077307-
dc.identifier.pmcidPMC124404en_HK
dc.identifier.scopuseid_2-s2.0-0037173048en_HK
dc.identifier.hkuros72931-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037173048&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue13en_HK
dc.identifier.spage8950en_HK
dc.identifier.epage8955en_HK
dc.identifier.isiWOS:000176478200086-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.scopusauthoridLipatov, AS=7005117347en_HK
dc.identifier.scopusauthoridEllis, TM=7202589926en_HK
dc.identifier.scopusauthoridDyrting, KC=6508235969en_HK
dc.identifier.scopusauthoridKrauss, S=7102769210en_HK
dc.identifier.scopusauthoridZhang, LJ=22137301100en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.citeulike4340438-

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