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Article: Protective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8+ T cells expressing gamma interferon

TitleProtective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8+ T cells expressing gamma interferon
Authors
Issue Date2002
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2002, v. 76 n. 10, p. 4886-4890 How to Cite?
AbstractA/Goose/Guangdong/1/96-like H5N1 influenza viruses now circulating in southeastern China differ genetically from the H5N1 viruses transmitted to humans in 1997 but were their precursors. Here we show that the currently circulating H9N2 influenza viruses provide chickens with cross-reactive protective immunity against the currently circulating HSN1 influenza viruses and that this protective immunity is closely related to the percentage of pulmonary CD8+ T cells expressing gamma interferon (IFN-γ). In vivo depletion of T-cell subsets showed that the cross-reactive immunity was mediated by T cells bearing CD8+ and T-cell receptor (TCR) α/β and that the Vβ1 subset of TCR α/β T cells had a dominant role in protective immunity. The protective immunity induced by infection with H9N2 virus declined with time, lasting as long as 100 days after immunization. Shedding of A/Goose/Guangdong/1/96-like H5N1 virus by immunized chickens also increased with the passage of time and thus may play a role in the perpetuation and spread of these highly pathogenic H5N1 influenza viruses. Our findings indicate that pulmonary cellular immunity may be very important in protecting naive natural hosts against lethal influenza viruses.
Persistent Identifierhttp://hdl.handle.net/10722/49218
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSeo, SHen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorWebster, RGen_HK
dc.date.accessioned2008-06-12T06:36:57Z-
dc.date.available2008-06-12T06:36:57Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Virology, 2002, v. 76 n. 10, p. 4886-4890en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49218-
dc.description.abstractA/Goose/Guangdong/1/96-like H5N1 influenza viruses now circulating in southeastern China differ genetically from the H5N1 viruses transmitted to humans in 1997 but were their precursors. Here we show that the currently circulating H9N2 influenza viruses provide chickens with cross-reactive protective immunity against the currently circulating HSN1 influenza viruses and that this protective immunity is closely related to the percentage of pulmonary CD8+ T cells expressing gamma interferon (IFN-γ). In vivo depletion of T-cell subsets showed that the cross-reactive immunity was mediated by T cells bearing CD8+ and T-cell receptor (TCR) α/β and that the Vβ1 subset of TCR α/β T cells had a dominant role in protective immunity. The protective immunity induced by infection with H9N2 virus declined with time, lasting as long as 100 days after immunization. Shedding of A/Goose/Guangdong/1/96-like H5N1 virus by immunized chickens also increased with the passage of time and thus may play a role in the perpetuation and spread of these highly pathogenic H5N1 influenza viruses. Our findings indicate that pulmonary cellular immunity may be very important in protecting naive natural hosts against lethal influenza viruses.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2002, v. 76 n. 10, p. 4886-4890en_HK
dc.subject.meshCD8-Positive T-Lymphocytes - immunologyen_HK
dc.subject.meshInterferon Type II - analysisen_HK
dc.subject.meshLung - immunologyen_HK
dc.subject.meshOrthomyxoviridae - immunologyen_HK
dc.subject.meshOrthomyxoviridae Infections - immunology - veterinaryen_HK
dc.titleProtective cross-reactive cellular immunity to lethal A/Goose/Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8+ T cells expressing gamma interferonen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=76&issue=10&spage=4886&epage=4890&date=2002&atitle=Protective+cross-reactive+cellular+immunity+to+lethal+A/Goose/Guangdong/1/96-like+H5N1+influenza+virus+is+correlated+with+the+proportion+of+pulmonary+CD8++T+cells+expressing+gamma+interferonen_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.76.10.4886-4890.2002en_HK
dc.identifier.pmid11967305-
dc.identifier.pmcidPMC136145en_HK
dc.identifier.scopuseid_2-s2.0-0036239484en_HK
dc.identifier.hkuros72916-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036239484&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue10en_HK
dc.identifier.spage4886en_HK
dc.identifier.epage4890en_HK
dc.identifier.isiWOS:000175256500021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSeo, SH=7202469843en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK

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