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Article: Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China

TitleCharacterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China
Authors
Issue Date2002
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2002, v. 76 n. 1, p. 118-126 How to Cite?
AbstractThe H5N1 influenza virus, which killed humans and poultry in 1997, was a reassortant that possibly arose in one type of domestic poultry present in the live-poultry markets of Hong Kong. Given that all the precursors of H5N1/97 are still circulating in poultry in southern China, the reassortment event that generated H5N1 could be repeated. Because A/goose/Guangdong/1/96-like (H5N1; Go/Gd) viruses are the proposed donors of the hemagglutinin gene of the H5N1 virus, we investigated the continued circulation, host range, and transmissibility of Go/Gd-like viruses in poultry. The Go/Gd-like viruses caused weight loss and death in some mice inoculated with high virus doses. Transmission of Go/Gd-like H5N1 viruses to geese by contact with infected geese resulted in infection of all birds but limited signs of overt disease. In contrast, oral inoculation with high doses of Go/Gd-like viruses resulted in the deaths of up to 50% of infected geese. Transmission from infected geese to chickens occurred only by fecal contact, whereas transmission to quail occurred by either aerosol or fecal spread. This difference is probably explained by the higher susceptibility of quail to Go/Gd-like virus. The high degree of susceptibility of quail to Go/Gd (H5N1)-like viruses and the continued circulation of H6N1 and H9N2 viruses in quail support the hypothesis that quail were the host of origin of the H5N1/97 virus. The ease of transmission of Go/Gd (H5N1)-like viruses to land-based birds, especially quail, supports the wisdom of separating aquatic and land-based poultry in the markets in Hong Kong and the need for continued surveillance in the field and live-bird markets in which different types of poultry are in contact with one another.
Persistent Identifierhttp://hdl.handle.net/10722/49215
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWebster, RGen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorWalker, Den_HK
dc.contributor.authorKrauss, Sen_HK
dc.contributor.authorNan Nan Zhouen_HK
dc.contributor.authorGovorkova, EAen_HK
dc.contributor.authorEllis, TMen_HK
dc.contributor.authorDyrting, KCen_HK
dc.contributor.authorSit, Ten_HK
dc.contributor.authorPerez, DRen_HK
dc.contributor.authorShortridge, KFen_HK
dc.date.accessioned2008-06-12T06:36:54Z-
dc.date.available2008-06-12T06:36:54Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Virology, 2002, v. 76 n. 1, p. 118-126en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49215-
dc.description.abstractThe H5N1 influenza virus, which killed humans and poultry in 1997, was a reassortant that possibly arose in one type of domestic poultry present in the live-poultry markets of Hong Kong. Given that all the precursors of H5N1/97 are still circulating in poultry in southern China, the reassortment event that generated H5N1 could be repeated. Because A/goose/Guangdong/1/96-like (H5N1; Go/Gd) viruses are the proposed donors of the hemagglutinin gene of the H5N1 virus, we investigated the continued circulation, host range, and transmissibility of Go/Gd-like viruses in poultry. The Go/Gd-like viruses caused weight loss and death in some mice inoculated with high virus doses. Transmission of Go/Gd-like H5N1 viruses to geese by contact with infected geese resulted in infection of all birds but limited signs of overt disease. In contrast, oral inoculation with high doses of Go/Gd-like viruses resulted in the deaths of up to 50% of infected geese. Transmission from infected geese to chickens occurred only by fecal contact, whereas transmission to quail occurred by either aerosol or fecal spread. This difference is probably explained by the higher susceptibility of quail to Go/Gd-like virus. The high degree of susceptibility of quail to Go/Gd (H5N1)-like viruses and the continued circulation of H6N1 and H9N2 viruses in quail support the hypothesis that quail were the host of origin of the H5N1/97 virus. The ease of transmission of Go/Gd (H5N1)-like viruses to land-based birds, especially quail, supports the wisdom of separating aquatic and land-based poultry in the markets in Hong Kong and the need for continued surveillance in the field and live-bird markets in which different types of poultry are in contact with one another.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2002, v. 76 n. 1, p. 118-126en_HK
dc.subject.meshDisease Vectorsen_HK
dc.subject.meshGeese - virologyen_HK
dc.subject.meshInfluenza A virus - isolation & purification - pathogenicity - physiologyen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshPoultry - virologyen_HK
dc.titleCharacterization of H5N1 influenza viruses that continue to circulate in geese in southeastern Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=76&issue=1&spage=118&epage=126&date=2002&atitle=Characterization+of+H5N1+influenza+viruses+that+continue+to+circulate+in+geese+in+southeastern+Chinaen_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.76.1.118-126.2002en_HK
dc.identifier.pmid11739677-
dc.identifier.pmcidPMC135698en_HK
dc.identifier.scopuseid_2-s2.0-0036133252en_HK
dc.identifier.hkuros72887-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036133252&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue1en_HK
dc.identifier.spage118en_HK
dc.identifier.epage126en_HK
dc.identifier.isiWOS:000172644900012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridWalker, D=7404440465en_HK
dc.identifier.scopusauthoridKrauss, S=7102769210en_HK
dc.identifier.scopusauthoridNan Nan Zhou=7409905910en_HK
dc.identifier.scopusauthoridGovorkova, EA=7003837718en_HK
dc.identifier.scopusauthoridEllis, TM=7202589926en_HK
dc.identifier.scopusauthoridDyrting, KC=6508235969en_HK
dc.identifier.scopusauthoridSit, T=36904517400en_HK
dc.identifier.scopusauthoridPerez, DR=7101996480en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK

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