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Article: Characterization of the influenza A virus gene pool in avian species in southern China: Was H6N1 a derivative or a precursor of H5N1?

TitleCharacterization of the influenza A virus gene pool in avian species in southern China: Was H6N1 a derivative or a precursor of H5N1?
Authors
Issue Date2000
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2000, v. 74 n. 14, p. 6309-6315 How to Cite?
AbstractIn 1997, an H5N1 influenza virus outbreak occurred in chickens in Hong Kong, and the virus was transmitted directly to humans. Because there is limited information about the avian influenza virus reservoir in that region, we genetically characterized virus strains isolated in Hong Kong during the 1997 outbreak. We sequenced the gene segments of a heterogeneous group of viruses of seven different serotypes (H3N8, H4N8, H6N1, H6N9, H11N1, H11N9, and H11N8) isolated from various bird species. The phylogenetic relationships divided these viruses into several subgroups. An H6N1 virus isolated from teal (A/teal/Hong Kong/W312/97 [H6N1]) showed very high (>98%) nucleotide homology to the human influenza virus A/Hong Kong/156/97 (H5N1) in the six internal genes. The N1 neuraminidase sequence showed 97% nucleotide homology to that of the human H5N1 virus, and the N1 protein of both viruses had the same 19-amino-acid deletion in the stalk region. The deduced hemagglutinin amino acid sequence of the H6N1 virus was most similar to that of A/shearwater/Australia/1/72 (H6N5). The H6N1 virus is the first known isolate with seven H5N1-like segments and may have been the donor of the neuraminidase and the internal genes of the H5N1 viruses. The high homology between the internal genes of H9N2, H6N1, and the H5N1 isolates indicates that these subtypes are able to exchange their internal genes and are therefore a potential source of new pathogenic influenza virus strains. Our analysis suggests that surveillance for influenza A viruses should be conducted for wild aquatic birds as well as for poultry, pigs, and humans and that H6 isolates should be further characterized.
Persistent Identifierhttp://hdl.handle.net/10722/49210
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHoffmann, Een_HK
dc.contributor.authorStech, Jen_HK
dc.contributor.authorLeneva, Ien_HK
dc.contributor.authorKrauss, Sen_HK
dc.contributor.authorScholtissek, Cen_HK
dc.contributor.authorChin, PSen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorWebster, RGen_HK
dc.date.accessioned2008-06-12T06:36:49Z-
dc.date.available2008-06-12T06:36:49Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Virology, 2000, v. 74 n. 14, p. 6309-6315en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49210-
dc.description.abstractIn 1997, an H5N1 influenza virus outbreak occurred in chickens in Hong Kong, and the virus was transmitted directly to humans. Because there is limited information about the avian influenza virus reservoir in that region, we genetically characterized virus strains isolated in Hong Kong during the 1997 outbreak. We sequenced the gene segments of a heterogeneous group of viruses of seven different serotypes (H3N8, H4N8, H6N1, H6N9, H11N1, H11N9, and H11N8) isolated from various bird species. The phylogenetic relationships divided these viruses into several subgroups. An H6N1 virus isolated from teal (A/teal/Hong Kong/W312/97 [H6N1]) showed very high (>98%) nucleotide homology to the human influenza virus A/Hong Kong/156/97 (H5N1) in the six internal genes. The N1 neuraminidase sequence showed 97% nucleotide homology to that of the human H5N1 virus, and the N1 protein of both viruses had the same 19-amino-acid deletion in the stalk region. The deduced hemagglutinin amino acid sequence of the H6N1 virus was most similar to that of A/shearwater/Australia/1/72 (H6N5). The H6N1 virus is the first known isolate with seven H5N1-like segments and may have been the donor of the neuraminidase and the internal genes of the H5N1 viruses. The high homology between the internal genes of H9N2, H6N1, and the H5N1 isolates indicates that these subtypes are able to exchange their internal genes and are therefore a potential source of new pathogenic influenza virus strains. Our analysis suggests that surveillance for influenza A viruses should be conducted for wild aquatic birds as well as for poultry, pigs, and humans and that H6 isolates should be further characterized.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2000, v. 74 n. 14, p. 6309-6315en_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshInfluenza A virus - classification - genetics - isolation & purification - pathogenicityen_HK
dc.subject.meshInfluenza in Birdsen_HK
dc.subject.meshMice, Inbred BALB Cen_HK
dc.titleCharacterization of the influenza A virus gene pool in avian species in southern China: Was H6N1 a derivative or a precursor of H5N1?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=74&issue=14&spage=6309&epage=6315&date=2000&atitle=Characterization+of+the+influenza+A+virus+gene+pool+in+avian+species+in+southern+China:+was+H6N1+a+derivative+or+a+precursor+of+H5N1?en_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.74.14.6309-6315.2000en_HK
dc.identifier.pmid10864640-
dc.identifier.pmcidPMC112136en_HK
dc.identifier.scopuseid_2-s2.0-0033945532en_HK
dc.identifier.hkuros54171-
dc.identifier.hkuros61978-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033945532&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue14en_HK
dc.identifier.spage6309en_HK
dc.identifier.epage6315en_HK
dc.identifier.isiWOS:000087817900009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHoffmann, E=7201369718en_HK
dc.identifier.scopusauthoridStech, J=23028967700en_HK
dc.identifier.scopusauthoridLeneva, I=6602522537en_HK
dc.identifier.scopusauthoridKrauss, S=7102769210en_HK
dc.identifier.scopusauthoridScholtissek, C=7006002772en_HK
dc.identifier.scopusauthoridChin, PS=7004662086en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridShortridge, KF=7005677034en_HK
dc.identifier.scopusauthoridWebster, RG=36048363100en_HK

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