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Article: Nasopharyngeal carriage of antimicrobial-resistant Streptococcus pneumoniae among young children attending 79 kindergartens and day care centers in Hong Kong

TitleNasopharyngeal carriage of antimicrobial-resistant Streptococcus pneumoniae among young children attending 79 kindergartens and day care centers in Hong Kong
Authors
Issue Date2001
PublisherAmerican Society for Microbiology.
Citation
Antimicrobial Agents And Chemotherapy, 2001, v. 45 n. 10, p. 2765-2770 How to Cite?
AbstractResistance to penicillin and multiple antimicrobial agents among Streptococcus pneumoniae strains is becoming an increasing problem worldwide and in Asia. To determine the prevalence of carriage of S. pneumoniae isolates not susceptible to penicillin in young children, we obtained nasopharyngeal swab specimens from 1,978 children (ages, 2 to 6 years) attending 79 day care centers or kindergartens. Three hundred eighty-three strains of S. pneumoniae were isolated from these children. Fifty-eight percent of these isolates had reduced susceptibility to penicillin, 123 (32.1%) were intermediate, and 100 (26.1%) were resistant. A very high penicillin MIC (4 μg/ml) was found in 3.3% of the isolates. The isolates also demonstrated high rates of resistance to other antimicrobial agents (51.2% to cefaclor, 50.2% to cefuroxime, 42.8% to cefotaxime, 80.7% to trimethoprimsulfamethoxazole, 77% to erythromycin, 60% to clindamycin, and 33.7% to chloramphenicol). No isolate was resistant to fluoroquinolone. Multidrug resistance (not susceptible to the β-lactams and three or more other classes) was found in 39.4% of the isolates. Risk factors for the carriage of S. pneumoniae not susceptible to penicillin were multiple physician visits in the preceding 3 months and use of antimicrobial agents by the individual or by household members in the preceding 3 months. In the logistic regression analysis, only the use of antimicrobial agents in the preceding 3 months was an independent risk factor (P = 0.004; odds ratio, 2; 95% confidence interval, 1.2 to 3.2). This study demonstrated the high prevalence of antibiotic-resistant S. pneumoniae in healthy young children in the community in Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/49205
ISSN
2015 Impact Factor: 4.415
2015 SCImago Journal Rankings: 2.322
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChiu, SSen_HK
dc.contributor.authorPak Leung Hoen_HK
dc.contributor.authorChow, FKHen_HK
dc.contributor.authorKwok Yung Yuenen_HK
dc.contributor.authorYu Lung Lauen_HK
dc.date.accessioned2008-06-12T06:36:43Z-
dc.date.available2008-06-12T06:36:43Z-
dc.date.issued2001en_HK
dc.identifier.citationAntimicrobial Agents And Chemotherapy, 2001, v. 45 n. 10, p. 2765-2770en_HK
dc.identifier.issn0066-4804en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49205-
dc.description.abstractResistance to penicillin and multiple antimicrobial agents among Streptococcus pneumoniae strains is becoming an increasing problem worldwide and in Asia. To determine the prevalence of carriage of S. pneumoniae isolates not susceptible to penicillin in young children, we obtained nasopharyngeal swab specimens from 1,978 children (ages, 2 to 6 years) attending 79 day care centers or kindergartens. Three hundred eighty-three strains of S. pneumoniae were isolated from these children. Fifty-eight percent of these isolates had reduced susceptibility to penicillin, 123 (32.1%) were intermediate, and 100 (26.1%) were resistant. A very high penicillin MIC (4 μg/ml) was found in 3.3% of the isolates. The isolates also demonstrated high rates of resistance to other antimicrobial agents (51.2% to cefaclor, 50.2% to cefuroxime, 42.8% to cefotaxime, 80.7% to trimethoprimsulfamethoxazole, 77% to erythromycin, 60% to clindamycin, and 33.7% to chloramphenicol). No isolate was resistant to fluoroquinolone. Multidrug resistance (not susceptible to the β-lactams and three or more other classes) was found in 39.4% of the isolates. Risk factors for the carriage of S. pneumoniae not susceptible to penicillin were multiple physician visits in the preceding 3 months and use of antimicrobial agents by the individual or by household members in the preceding 3 months. In the logistic regression analysis, only the use of antimicrobial agents in the preceding 3 months was an independent risk factor (P = 0.004; odds ratio, 2; 95% confidence interval, 1.2 to 3.2). This study demonstrated the high prevalence of antibiotic-resistant S. pneumoniae in healthy young children in the community in Hong Kong.en_HK
dc.format.extent384 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofAntimicrobial Agents and Chemotherapyen_HK
dc.rightsAntimicrobial Agents and Chemotherapy. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 2001, v. 45 n. 10, p. 2765-2770en_HK
dc.subject.meshAnti-Bacterial Agents - pharmacologyen_HK
dc.subject.meshCarrier State - microbiologyen_HK
dc.subject.meshNasopharynx - microbiologyen_HK
dc.subject.meshStreptococcus pneumoniae - drug effectsen_HK
dc.subject.meshChild Day Care Centersen_HK
dc.titleNasopharyngeal carriage of antimicrobial-resistant Streptococcus pneumoniae among young children attending 79 kindergartens and day care centers in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0066-4804&volume=45&issue=10&spage=2765&epage=2770&date=2001&atitle=Nasopharyngeal+carriage+of+antimicrobial-resistant+Streptococcus+pneumoniae+among+young+children+attending+79+kindergartens+and+day+care+centers+in+Hong+Kongen_HK
dc.identifier.emailChiu, SS:ssschiu@hkucc.hku.hken_HK
dc.identifier.emailPak Leung Ho:plho@hkucc.hku.hken_HK
dc.identifier.emailKwok Yung Yuen:kyyuen@hkucc.hku.hken_HK
dc.identifier.emailYu Lung Lau:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChiu, SS=rp00421en_HK
dc.identifier.authorityPak Leung Ho=rp00406en_HK
dc.identifier.authorityKwok Yung Yuen=rp00366en_HK
dc.identifier.authorityYu Lung Lau=rp00361en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/AAC.45.10.2765-2770.2001en_HK
dc.identifier.pmid11557466-
dc.identifier.pmcidPMC90728en_HK
dc.identifier.scopuseid_2-s2.0-0034806947en_HK
dc.identifier.hkuros61632-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034806947&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume45en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2765en_HK
dc.identifier.epage2770en_HK
dc.identifier.isiWOS:000171154500014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChiu, SS=7202291500en_HK
dc.identifier.scopusauthoridPak Leung Ho=7402211363en_HK
dc.identifier.scopusauthoridChow, FKH=36640352900en_HK
dc.identifier.scopusauthoridKwok Yung Yuen=36078079100en_HK
dc.identifier.scopusauthoridYu Lung Lau=7201403380en_HK

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