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Article: Clarithromycin attenuates mastectomy-induced acute inflammatory response

TitleClarithromycin attenuates mastectomy-induced acute inflammatory response
Authors
Issue Date2000
PublisherAmerican Society for Microbiology.
Citation
Clinical And Diagnostic Laboratory Immunology, 2000, v. 7 n. 6, p. 925-931 How to Cite?
AbstractBased on the observation that administration of clarithromycin led to an attenuation of the inflammatory response induced by surgical trauma in a guinea pig model, we investigated the potential beneficial effects of clarithromycin on the local and systemic inflammatory response in patients undergoing mastectomy in an open-label prospective study. During a 16-month period, 54 patients who underwent mastectomy were randomly divided into two groups. In one group, the patients received oral clarithromycin at a dose of 500 mg twice a day, from the day before to 3 days after mastectomy. There was no significant difference in the incidence of antibiotic prophylaxis-related toxicities or postoperative infections between the patients who received clarithromycin and those who did not. Clarithromycin treatment was significantly associated with an attenuation of febrile response, tachycardia, tachypnea, and an increase in monocyte counts (P, <0.0001, <0.01, <0.05, and <0.01, respectively). Clarithromycin also reduced the intensity and duration of postoperative pain (P, <0.05 and <0.005, respectively) and increased the range of motion of the involved shoulder (P < 0.05 for abduction and flexion). We conclude that clarithromycin effectively modulates the acute inflammatory response associated with mastectomy and produces a better clinical outcome.
Persistent Identifierhttp://hdl.handle.net/10722/49200
ISSN
2007 Impact Factor: 2.511
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, LWCen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorWoo, PCYen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2008-06-12T06:36:36Z-
dc.date.available2008-06-12T06:36:36Z-
dc.date.issued2000en_HK
dc.identifier.citationClinical And Diagnostic Laboratory Immunology, 2000, v. 7 n. 6, p. 925-931en_HK
dc.identifier.issn1071-412Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49200-
dc.description.abstractBased on the observation that administration of clarithromycin led to an attenuation of the inflammatory response induced by surgical trauma in a guinea pig model, we investigated the potential beneficial effects of clarithromycin on the local and systemic inflammatory response in patients undergoing mastectomy in an open-label prospective study. During a 16-month period, 54 patients who underwent mastectomy were randomly divided into two groups. In one group, the patients received oral clarithromycin at a dose of 500 mg twice a day, from the day before to 3 days after mastectomy. There was no significant difference in the incidence of antibiotic prophylaxis-related toxicities or postoperative infections between the patients who received clarithromycin and those who did not. Clarithromycin treatment was significantly associated with an attenuation of febrile response, tachycardia, tachypnea, and an increase in monocyte counts (P, <0.0001, <0.01, <0.05, and <0.01, respectively). Clarithromycin also reduced the intensity and duration of postoperative pain (P, <0.05 and <0.005, respectively) and increased the range of motion of the involved shoulder (P < 0.05 for abduction and flexion). We conclude that clarithromycin effectively modulates the acute inflammatory response associated with mastectomy and produces a better clinical outcome.en_HK
dc.format.extent384 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofClinical and Diagnostic Laboratory Immunologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsClinical and Diagnostic Laboratory Immunology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Clinical and Diagnostic Laboratory Immunology, 2000, v. 7 n. 6, p. 925-931en_HK
dc.subject.meshAnti-Bacterial Agents - administration & dosage - therapeutic useen_HK
dc.subject.meshClarithromycin - administration & dosage - therapeutic useen_HK
dc.subject.meshInflammation - drug therapy - etiologyen_HK
dc.subject.meshMastectomy - adverse effectsen_HK
dc.subject.meshPostoperative Complications - drug therapy - etiologyen_HK
dc.titleClarithromycin attenuates mastectomy-induced acute inflammatory responseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1071-412X&volume=7&issue=6&spage=925&epage=931&date=2000&atitle=Clarithromycin+attenuates+mastectomy-induced+acute+inflammatory+responseen_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityWoo, PCY=rp00430en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/CDLI.7.6.925-931.2000en_HK
dc.identifier.pmid11063500-
dc.identifier.pmcidPMC95987en_HK
dc.identifier.scopuseid_2-s2.0-0034459014en_HK
dc.identifier.hkuros56208-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034459014&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue6en_HK
dc.identifier.spage925en_HK
dc.identifier.epage931en_HK
dc.identifier.isiWOS:000167743800014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChow, LWC=7202532995en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridWoo, PCY=7201801340en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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