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Article: Avian-to-human transmission of H9N2 subtype influenza A viruses: Relationship between H9N2 and H5N1 human isolates
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TitleAvian-to-human transmission of H9N2 subtype influenza A viruses: Relationship between H9N2 and H5N1 human isolates
 
AuthorsLin, YP2
Shaw, M5
Gregory, V2
Cameron, K2
Lim, W3
Klimov, A5
Subbarao, K5
Guan, Y1 4
Krauss, S4
Shortridge, K1
Webster, R4
Cox, N5
Hay, A2
 
Issue Date2000
 
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
 
CitationProceedings Of The National Academy Of Sciences Of The United States Of America, 2000, v. 97 n. 17, p. 9654-9658 [How to Cite?]
 
AbstractIn 1997, 18 cases of influenza in Hong Kong (bird flu) caused by a novel H5N1 (chicken) virus resulted in the deaths of six individuals and once again raised the specter of a potentially devastating influenza pandemic. Slaughter of the poultry in the live bird markets removed the source of infection and no further human cases of H5N1 infection have occurred. In March 1999, however, a new pandemic threat appeared when influenza A H9N2 viruses infected two children in Hong Kong. These two virus isolates are similar to an H9N2 virus isolated from a quail in Hong Kong in late 1997. Although differing in their surface hemagglutinin and neuraminidase components, a notable feature of these H9N2 viruses is that the six genes encoding the internal components of the virus are similar to those of the 1997 H5N1 human and avian isolates. This common feature emphasizes the apparent propensity of avian viruses with this genetic complement to infect humans and highlights the potential for the emergence of a novel human pathogen.
 
ISSN0027-8424
2013 Impact Factor: 9.809
 
PubMed Central IDPMC16920
 
ISI Accession Number IDWOS:000088840500058
 
ReferencesReferences in Scopus
 
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dc.contributor.authorLin, YP
 
dc.contributor.authorShaw, M
 
dc.contributor.authorGregory, V
 
dc.contributor.authorCameron, K
 
dc.contributor.authorLim, W
 
dc.contributor.authorKlimov, A
 
dc.contributor.authorSubbarao, K
 
dc.contributor.authorGuan, Y
 
dc.contributor.authorKrauss, S
 
dc.contributor.authorShortridge, K
 
dc.contributor.authorWebster, R
 
dc.contributor.authorCox, N
 
dc.contributor.authorHay, A
 
dc.date.accessioned2008-06-12T06:36:33Z
 
dc.date.available2008-06-12T06:36:33Z
 
dc.date.issued2000
 
dc.description.abstractIn 1997, 18 cases of influenza in Hong Kong (bird flu) caused by a novel H5N1 (chicken) virus resulted in the deaths of six individuals and once again raised the specter of a potentially devastating influenza pandemic. Slaughter of the poultry in the live bird markets removed the source of infection and no further human cases of H5N1 infection have occurred. In March 1999, however, a new pandemic threat appeared when influenza A H9N2 viruses infected two children in Hong Kong. These two virus isolates are similar to an H9N2 virus isolated from a quail in Hong Kong in late 1997. Although differing in their surface hemagglutinin and neuraminidase components, a notable feature of these H9N2 viruses is that the six genes encoding the internal components of the virus are similar to those of the 1997 H5N1 human and avian isolates. This common feature emphasizes the apparent propensity of avian viruses with this genetic complement to infect humans and highlights the potential for the emergence of a novel human pathogen.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent384 bytes
 
dc.format.mimetypetext/html
 
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2000, v. 97 n. 17, p. 9654-9658 [How to Cite?]
 
dc.identifier.epage9658
 
dc.identifier.hkuros54176
 
dc.identifier.isiWOS:000088840500058
 
dc.identifier.issn0027-8424
2013 Impact Factor: 9.809
 
dc.identifier.issue17
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC16920
 
dc.identifier.pmid10920197
 
dc.identifier.scopuseid_2-s2.0-12944270582
 
dc.identifier.spage9654
 
dc.identifier.urihttp://hdl.handle.net/10722/49197
 
dc.identifier.volume97
 
dc.languageeng
 
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
 
dc.relation.referencesReferences in Scopus
 
dc.rightsNational Academy of Sciences Proceedings. Copyright © National Academy of Sciences.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshBird Diseases - epidemiology - transmission
 
dc.subject.meshInfluenza A Virus, H5N1 Subtype
 
dc.subject.meshInfluenza A Virus, H9N2 Subtype
 
dc.subject.meshInfluenza A virus - chemistry - classification - genetics - immunology
 
dc.subject.meshInfluenza, Human - epidemiology - transmission
 
dc.titleAvian-to-human transmission of H9N2 subtype influenza A viruses: Relationship between H9N2 and H5N1 human isolates
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. MRC National Institute for Medical Research
  3. Queen Mary Hospital Hong Kong
  4. St. Jude Children Research Hospital
  5. Centers for Disease Control and Prevention