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Article: Detection of specific antibodies to an antigenic mannoprotein for diagnosis of Penicillium marneffei penicilliosis

TitleDetection of specific antibodies to an antigenic mannoprotein for diagnosis of Penicillium marneffei penicilliosis
Authors
Issue Date1998
PublisherAmerican Society for Microbiology.
Citation
Journal Of Clinical Microbiology, 1998, v. 36 n. 10, p. 3028-3031 How to Cite?
AbstractThe disseminated and progressive fungal disease Penicillium marneffei penicilliosis is one of the most common infectious diseases in AIDS patients in Southeast Asia. To diagnose systemic penicilliosis, we developed an enzyme-linked immunosorbent assay (ELISA)-based antibody test with Mp1p, a purified recombinant antigenic mannoprotein of P. marneffei. Evaluation of the test with guinea pig sera against P. marneffei and other pathogenic fungi indicated that this assay was specific for P. marneffei. Clinical evaluation revealed that high levels of specific antibody were detected in two immunocompetent penicilliosis patients. Furthermore, approximately 80% (14 of 17) of the documented penicilliosis patients with human immunodeficiency virus tested positive for the specific antibody. No false-positive results were found for serum samples from 90 healthy blood donors, 20 patients with typhoid fever, and 55 patients with tuberculosis, indicating a high specificity of the test. Thus, this ELISA-based test for the detection of anti-Mp1p antibody can be of significant value as a diagnostic for penicilliosis.
Persistent Identifierhttp://hdl.handle.net/10722/49192
ISSN
2015 Impact Factor: 3.631
2015 SCImago Journal Rankings: 2.151
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCao, Len_HK
dc.contributor.authorChen, DLen_HK
dc.contributor.authorLee, Cen_HK
dc.contributor.authorChan, CMen_HK
dc.contributor.authorChan, KMen_HK
dc.contributor.authorVanittanakom, Nen_HK
dc.contributor.authorTsang, DNCen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2008-06-12T06:36:26Z-
dc.date.available2008-06-12T06:36:26Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Clinical Microbiology, 1998, v. 36 n. 10, p. 3028-3031en_HK
dc.identifier.issn0095-1137en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49192-
dc.description.abstractThe disseminated and progressive fungal disease Penicillium marneffei penicilliosis is one of the most common infectious diseases in AIDS patients in Southeast Asia. To diagnose systemic penicilliosis, we developed an enzyme-linked immunosorbent assay (ELISA)-based antibody test with Mp1p, a purified recombinant antigenic mannoprotein of P. marneffei. Evaluation of the test with guinea pig sera against P. marneffei and other pathogenic fungi indicated that this assay was specific for P. marneffei. Clinical evaluation revealed that high levels of specific antibody were detected in two immunocompetent penicilliosis patients. Furthermore, approximately 80% (14 of 17) of the documented penicilliosis patients with human immunodeficiency virus tested positive for the specific antibody. No false-positive results were found for serum samples from 90 healthy blood donors, 20 patients with typhoid fever, and 55 patients with tuberculosis, indicating a high specificity of the test. Thus, this ELISA-based test for the detection of anti-Mp1p antibody can be of significant value as a diagnostic for penicilliosis.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofJournal of Clinical Microbiologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Clinical Microbiology, 1998, v. 36 n. 10, p. 3028-3031en_HK
dc.subject.meshAIDS-Related Opportunistic Infections - diagnosis - immunology - microbiologyen_HK
dc.subject.meshAntibodies, Fungal - blooden_HK
dc.subject.meshAntigens, Fungal - immunologyen_HK
dc.subject.meshMembrane Glycoproteins - immunologyen_HK
dc.subject.meshPenicillium - immunology - isolation & purificationen_HK
dc.titleDetection of specific antibodies to an antigenic mannoprotein for diagnosis of Penicillium marneffei penicilliosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0095-1137&volume=36&issue=10&spage=3028&epage=3031&date=1998&atitle=Detection+of+specific+antibodies+to+an+antigenic+mannoprotein+for+diagnosis+of+Penicillium+marneffei+penicilliosisen_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9738061-
dc.identifier.pmcidPMC105105en_HK
dc.identifier.scopuseid_2-s2.0-0031659295en_HK
dc.identifier.hkuros44994-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031659295&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue10en_HK
dc.identifier.spage3028en_HK
dc.identifier.epage3031en_HK
dc.identifier.isiWOS:000075896800038-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCao, L=7401637818en_HK
dc.identifier.scopusauthoridChen, DL=15820196100en_HK
dc.identifier.scopusauthoridLee, C=7410162028en_HK
dc.identifier.scopusauthoridChan, CM=7404814453en_HK
dc.identifier.scopusauthoridChan, KM=26324790600en_HK
dc.identifier.scopusauthoridVanittanakom, N=6603939234en_HK
dc.identifier.scopusauthoridTsang, DNC=7005609132en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK

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