File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Rapid evolution of H5N1 influenza viruses in chickens in Hong Kong

TitleRapid evolution of H5N1 influenza viruses in chickens in Hong Kong
Authors
Issue Date1999
PublisherAmerican Society for Microbiology.
Citation
Journal of Virology, 1999, v. 73 n. 4, p. 3366-3374 How to Cite?
AbstractThe H5N1 avian influenza virus that killed 6 of 18 persons infected in Hong Kong in 1997 was transmitted directly from poultry to humans. Viral isolates from this outbreak may provide molecular clues to zoonotic transfer. Here we demonstrate that the H5N1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution. When introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins, especially in the hemagglutinin (HA). Surprisingly, these H5N1 isolates had a large proportion of amino acid changes in all gene products except in the HA. These viruses maybe reassortants each of whose HA gene is well adapted to domestic poultry while the rest of the genome arises from a different source. The consensus amino acid sequences of 'internal' virion proteins reveal amino acids previously found in human strains. These human-specific amino acids may be important factors in zoonotic transmission.
Persistent Identifierhttp://hdl.handle.net/10722/49190
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, NNen_HK
dc.contributor.authorShortridge, KFen_HK
dc.contributor.authorClaas, ECJen_HK
dc.contributor.authorKrauss, SLen_HK
dc.contributor.authorWebster, RGen_HK
dc.date.accessioned2008-06-12T06:36:24Z-
dc.date.available2008-06-12T06:36:24Z-
dc.date.issued1999en_HK
dc.identifier.citationJournal of Virology, 1999, v. 73 n. 4, p. 3366-3374en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49190-
dc.description.abstractThe H5N1 avian influenza virus that killed 6 of 18 persons infected in Hong Kong in 1997 was transmitted directly from poultry to humans. Viral isolates from this outbreak may provide molecular clues to zoonotic transfer. Here we demonstrate that the H5N1 viruses circulating in poultry comprised two distinguishable phylogenetic lineages in all genes that were in very rapid evolution. When introduced into new hosts, influenza viruses usually undergo rapid alteration of their surface glycoproteins, especially in the hemagglutinin (HA). Surprisingly, these H5N1 isolates had a large proportion of amino acid changes in all gene products except in the HA. These viruses maybe reassortants each of whose HA gene is well adapted to domestic poultry while the rest of the genome arises from a different source. The consensus amino acid sequences of 'internal' virion proteins reveal amino acids previously found in human strains. These human-specific amino acids may be important factors in zoonotic transmission.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 1999, v. 73 n. 4, p. 3366-3374en_HK
dc.subject.meshGenes, Viralen_HK
dc.subject.meshGenome, Viralen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtypeen_HK
dc.subject.meshInfluenza A virus - geneticsen_HK
dc.subject.meshInfluenza in Birds - epidemiology - transmission - virologyen_HK
dc.titleRapid evolution of H5N1 influenza viruses in chickens in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=73&issue=4&spage=3366&epage=3374&date=1999&atitle=Rapid+evolution+of+H5N1+influenza+viruses+in+chickens+in+Hong+Kongen_HK
dc.identifier.emailShortridge, KF: microgen@hkucc.hku.hken_HK
dc.identifier.emailWebster, RG: stjude@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid10074191-
dc.identifier.pmcidPMC104101en_HK
dc.identifier.scopuseid_2-s2.0-0345391024-
dc.identifier.hkuros44875-
dc.identifier.isiWOS:000079122400091-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats