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Article: The effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid media

TitleThe effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid media
Authors
Issue Date1998
PublisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/
Citation
Journal of Antimicrobial Chemotherapy, 1998, v. 41 n. 3, p. 357-366 How to Cite?
AbstractThe effect of drugs in combination on the growth of Candida glabrata was studied in solid medium by demonstration of reduced or enhanced growth, and in liquid medium by determination of interaction indices. Amphotericin B and 5-fluorocytosine showed a synergic effect, while combinations of amphotericin B and miconazole, and miconazole and 5-fluorocytosine exhibited antagonistic effects. In addition, concentration-dependent antagonism was observed amongst combinations of metabolic inhibitors, between inhibitors of sterol biosynthesis (terbinafine, miconazole, ketoconazole, clotrimazole, econazole, fluconazole, itraconazole and amorolfine) and inhibitors of nucleic acid or protein biosynthesis (5-fluorocytosine, 5-fluorouracil, rifampicin and chlortetracycline). This antagonism was strain-specific, occurring with C. glabrata strain 4, Saccharomyces cerevisiae strain 237 and Candida albicans strain 72R, but not with C. albicans strain 6406 or Candida parapsilosis strain 3104.
Persistent Identifierhttp://hdl.handle.net/10722/49185
ISSN
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ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSiau, Hen_HK
dc.contributor.authorKerridge, Den_HK
dc.date.accessioned2008-06-12T06:36:17Z-
dc.date.available2008-06-12T06:36:17Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal of Antimicrobial Chemotherapy, 1998, v. 41 n. 3, p. 357-366en_HK
dc.identifier.issn0305-7453en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49185-
dc.description.abstractThe effect of drugs in combination on the growth of Candida glabrata was studied in solid medium by demonstration of reduced or enhanced growth, and in liquid medium by determination of interaction indices. Amphotericin B and 5-fluorocytosine showed a synergic effect, while combinations of amphotericin B and miconazole, and miconazole and 5-fluorocytosine exhibited antagonistic effects. In addition, concentration-dependent antagonism was observed amongst combinations of metabolic inhibitors, between inhibitors of sterol biosynthesis (terbinafine, miconazole, ketoconazole, clotrimazole, econazole, fluconazole, itraconazole and amorolfine) and inhibitors of nucleic acid or protein biosynthesis (5-fluorocytosine, 5-fluorouracil, rifampicin and chlortetracycline). This antagonism was strain-specific, occurring with C. glabrata strain 4, Saccharomyces cerevisiae strain 237 and Candida albicans strain 72R, but not with C. albicans strain 6406 or Candida parapsilosis strain 3104.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jac.oxfordjournals.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAmphotericin B - administration & dosage - pharmacologyen_HK
dc.subject.meshAntifungal Agents - administration & dosage - pharmacologyen_HK
dc.subject.meshCandida - cytology - drug effects - growth & developmenten_HK
dc.subject.meshFlucytosine - administration & dosage - pharmacologyen_HK
dc.subject.meshAgaren_HK
dc.titleThe effect of antifungal drugs in combination on the growth of Candida glabrata in solid and liquid mediaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-7453&volume=41&issue=3&spage=357&epage=366&date=1998&atitle=The+effect+of+antifungal+drugs+in+combination+on+the+growth+of+Candida+glabrata+in+solid+and+liquid+mediaen_HK
dc.identifier.emailSiau, H: hongsiau@hkusua.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1093/jac/41.3.357en_HK
dc.identifier.pmid9578162-
dc.identifier.scopuseid_2-s2.0-0031954527-
dc.identifier.hkuros36661-
dc.identifier.isiWOS:000073501500007-

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