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Article: Primary human herpes virus 6 infection transmitted from donor to recipient through bone marrow infusion

TitlePrimary human herpes virus 6 infection transmitted from donor to recipient through bone marrow infusion
Authors
KeywordsFoscarnet
Ganciclovir
HHV 6
Infection
Myelosuppression
Wiskott-Aldrich syndrome
Issue Date1998
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 1998, v. 21 n. 10, p. 1063-1066 How to Cite?
AbstractAn 8.5-month-old boy with Wiskott-Aldrich syndrome received a sibling matched bone marrow transplant from his healthy non-identical twin brother. The donor had primary human herpes virus 6 (HHV-6) infection around the time of bone marrow donation. The recipient had hepatitis in the first week and then developed fever and rash on day 18. Skin biopsy was shown to have HHV-6 antigen and his peripheral blood leukocytes were HHV-6 DNA positive. He engrafted on day 18 but the ANC dropped from 5.5 x 109/l (day 23) to 0.48 x 109/l (day 34) with persistent HHV-6 DNAemia. Bone marrow on day 35 was positive for HHV-6 DNA. He was treated with G-CSF and ganciclovir with good response. He later had pneumonitis which was treated empirically with foscarnet, ceftazidime and clarithromycin.
Persistent Identifierhttp://hdl.handle.net/10722/49183
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, YLen_HK
dc.contributor.authorPeiris, Men_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorChiu, Den_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2008-06-12T06:36:15Z-
dc.date.available2008-06-12T06:36:15Z-
dc.date.issued1998en_HK
dc.identifier.citationBone Marrow Transplantation, 1998, v. 21 n. 10, p. 1063-1066en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49183-
dc.description.abstractAn 8.5-month-old boy with Wiskott-Aldrich syndrome received a sibling matched bone marrow transplant from his healthy non-identical twin brother. The donor had primary human herpes virus 6 (HHV-6) infection around the time of bone marrow donation. The recipient had hepatitis in the first week and then developed fever and rash on day 18. Skin biopsy was shown to have HHV-6 antigen and his peripheral blood leukocytes were HHV-6 DNA positive. He engrafted on day 18 but the ANC dropped from 5.5 x 109/l (day 23) to 0.48 x 109/l (day 34) with persistent HHV-6 DNAemia. Bone marrow on day 35 was positive for HHV-6 DNA. He was treated with G-CSF and ganciclovir with good response. He later had pneumonitis which was treated empirically with foscarnet, ceftazidime and clarithromycin.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFoscarneten_HK
dc.subjectGancicloviren_HK
dc.subjectHHV 6en_HK
dc.subjectInfectionen_HK
dc.subjectMyelosuppressionen_HK
dc.subjectWiskott-Aldrich syndromeen_HK
dc.titlePrimary human herpes virus 6 infection transmitted from donor to recipient through bone marrow infusionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=21&issue=10&spage=1063&epage=1066&date=1998&atitle=Primary+human+herpes+virus+6+infection+transmitted+from+donor+to+recipient+through+bone+marrow+infusionen_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailPeiris, M: malik@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF: gcfchan@hku.hken_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityPeiris, M=rp00410en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1038/sj.bmt.1701230en_HK
dc.identifier.pmid9632282-
dc.identifier.scopuseid_2-s2.0-0031797550en_HK
dc.identifier.hkuros31714-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031797550&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1063en_HK
dc.identifier.epage1066en_HK
dc.identifier.isiWOS:000073631800015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridPeiris, M=7005486823en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridChiu, D=16749062300en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK

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