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Article: Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms

TitleMolecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms
Authors
Issue Date2005
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2005, v. 79 n. 18, p. 11892-11900 How to Cite?
Abstract
Massive numbers of palm civets were culled to remove sources for the reemergence of severe acute respiratory syndrome (SARS) in Guangdong Province, China, in January 2004, following SARS coronavirus detection in market animals. The virus was identified in all 91 palm civets and 15 raccoon dogs of animal market origin sampled prior to culling, but not in 1,107 palm civets later sampled at 25 farms, spread over 12 provinces, which were claimed to be the source of traded animals. Twenty-seven novel signature variation residues (SNVs) were identified on the spike gene and were analyzed for their phylogenetic relationships, based on 17 sequences obtained from animals in our study and from other published studies. Analysis indicated that the virus in palm civets at the live-animal market had evolved to infect humans. The evolutionary starting point was a prototype group consisting of three viral sequences of animal origin. Initially, seven SNV sites caused six amino acid changes, at positions 147, 228, 240, 479, 821, and 1080 of the spike protein, to generate low-pathogenicity viruses. One of these was linked to the first SARS patient in the 2003-2004 period. A further 14 SNVs caused 11 amino acid residue changes, at positions 360, 462, 472, 480, 487, 609, 613, 665, 743, 765, and 1163. The resulting high-pathogenicity groups were responsible for infections during the so-called early-phase epidemic of 2003. Finally, the remaining six SNVs caused four amino acid changes, at positions 227, 244, 344, and 778, which resulted in the group of viruses responsible for the global epidemic. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
DescriptionErratum in: Journal of Virology 2006 Aug;80(15):7786
Persistent Identifierhttp://hdl.handle.net/10722/49166
ISSN
2013 Impact Factor: 4.648
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKan, Ben_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorJing, Hen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorJiang, Xen_HK
dc.contributor.authorYan, Men_HK
dc.contributor.authorLiang, Wen_HK
dc.contributor.authorZheng, Hen_HK
dc.contributor.authorWan, Ken_HK
dc.contributor.authorLiu, Qen_HK
dc.contributor.authorCui, Ben_HK
dc.contributor.authorXu, Yen_HK
dc.contributor.authorZhang, Een_HK
dc.contributor.authorWang, Hen_HK
dc.contributor.authorYe, Jen_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorLi, Men_HK
dc.contributor.authorCui, Zen_HK
dc.contributor.authorQi, Xen_HK
dc.contributor.authorChen, Ken_HK
dc.contributor.authorDu, Len_HK
dc.contributor.authorGao, Ken_HK
dc.contributor.authorZhao, YTen_HK
dc.contributor.authorZou, XZen_HK
dc.contributor.authorFeng, YJen_HK
dc.contributor.authorGao, YFen_HK
dc.contributor.authorHai, Ren_HK
dc.contributor.authorYu, Den_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorXu, Jen_HK
dc.date.accessioned2008-06-12T06:35:54Z-
dc.date.available2008-06-12T06:35:54Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Virology, 2005, v. 79 n. 18, p. 11892-11900en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49166-
dc.descriptionErratum in: Journal of Virology 2006 Aug;80(15):7786en_HK
dc.description.abstractMassive numbers of palm civets were culled to remove sources for the reemergence of severe acute respiratory syndrome (SARS) in Guangdong Province, China, in January 2004, following SARS coronavirus detection in market animals. The virus was identified in all 91 palm civets and 15 raccoon dogs of animal market origin sampled prior to culling, but not in 1,107 palm civets later sampled at 25 farms, spread over 12 provinces, which were claimed to be the source of traded animals. Twenty-seven novel signature variation residues (SNVs) were identified on the spike gene and were analyzed for their phylogenetic relationships, based on 17 sequences obtained from animals in our study and from other published studies. Analysis indicated that the virus in palm civets at the live-animal market had evolved to infect humans. The evolutionary starting point was a prototype group consisting of three viral sequences of animal origin. Initially, seven SNV sites caused six amino acid changes, at positions 147, 228, 240, 479, 821, and 1080 of the spike protein, to generate low-pathogenicity viruses. One of these was linked to the first SARS patient in the 2003-2004 period. A further 14 SNVs caused 11 amino acid residue changes, at positions 360, 462, 472, 480, 487, 609, 613, 665, 743, 765, and 1163. The resulting high-pathogenicity groups were responsible for infections during the so-called early-phase epidemic of 2003. Finally, the remaining six SNVs caused four amino acid changes, at positions 227, 244, 344, and 778, which resulted in the group of viruses responsible for the global epidemic. Copyright © 2005, American Society for Microbiology. All Rights Reserved.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2005, v. 79 n. 18, p. 11892-11900en_HK
dc.subject.meshEvolution, Molecularen_HK
dc.subject.meshSARS Virus - classification - genetics - isolation & purificationen_HK
dc.subject.meshViverridae - virologyen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - epidemiology - transmission - virologyen_HK
dc.subject.meshViral Envelope Proteins - geneticsen_HK
dc.titleMolecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farmsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=79&issue=18&spage=11892&epage=11900&date=2005&atitle=Molecular+evolution+analysis+and+geographic+investigation+of+severe+acute+respiratory+syndrome+coronavirus-like+virus+in+palm+civets+at+an+animal+market+and+on+farmsen_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.79.18.11892-11900.2005en_HK
dc.identifier.pmid16140765en_HK
dc.identifier.pmcidPMC1212604en_HK
dc.identifier.scopuseid_2-s2.0-24644457565en_HK
dc.identifier.hkuros110152-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24644457565&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume79en_HK
dc.identifier.issue18en_HK
dc.identifier.spage11892en_HK
dc.identifier.epage11900en_HK
dc.identifier.isiWOS:000231633900034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKan, B=7004014966en_HK
dc.identifier.scopusauthoridWang, M=7406685232en_HK
dc.identifier.scopusauthoridJing, H=7101842573en_HK
dc.identifier.scopusauthoridXu, H=7407448207en_HK
dc.identifier.scopusauthoridJiang, X=7404628139en_HK
dc.identifier.scopusauthoridYan, M=55438160300en_HK
dc.identifier.scopusauthoridLiang, W=8724705400en_HK
dc.identifier.scopusauthoridZheng, H=7403441401en_HK
dc.identifier.scopusauthoridWan, K=7102748961en_HK
dc.identifier.scopusauthoridLiu, Q=34877172400en_HK
dc.identifier.scopusauthoridCui, B=35098364600en_HK
dc.identifier.scopusauthoridXu, Y=8724706200en_HK
dc.identifier.scopusauthoridZhang, E=8837819300en_HK
dc.identifier.scopusauthoridWang, H=7501732532en_HK
dc.identifier.scopusauthoridYe, J=22982405600en_HK
dc.identifier.scopusauthoridLi, G=8724707000en_HK
dc.identifier.scopusauthoridLi, M=8724707100en_HK
dc.identifier.scopusauthoridCui, Z=8543262000en_HK
dc.identifier.scopusauthoridQi, X=14045610900en_HK
dc.identifier.scopusauthoridChen, K=54790558800en_HK
dc.identifier.scopusauthoridDu, L=35740266200en_HK
dc.identifier.scopusauthoridGao, K=36795368400en_HK
dc.identifier.scopusauthoridZhao, YT=7407399215en_HK
dc.identifier.scopusauthoridZou, XZ=8724708000en_HK
dc.identifier.scopusauthoridFeng, YJ=8724708100en_HK
dc.identifier.scopusauthoridGao, YF=14045101900en_HK
dc.identifier.scopusauthoridHai, R=6603029779en_HK
dc.identifier.scopusauthoridYu, D=10338984600en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridXu, J=8101558800en_HK

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