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Article: Cytokine gene expression profile of circulating CD4 + T cells in active pulmonary tuberculosis

TitleCytokine gene expression profile of circulating CD4 + T cells in active pulmonary tuberculosis
Authors
Keywordscytokines
helper T cells
interleukin 2
T lymphocytes
tuberculosis
Issue Date1997
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 1997, v. 111 n. 3, p. 606-611 How to Cite?
AbstractT lymphocytes, particularly CD4 + cells, are thought to play an important role in the immune defense against Mycobacterium tuberculosis through the release of their wide array of cytokines. In vitro studies suggest that Mycobacterium-specific T-cell clones are of the TH 1 subtype. Using the technique of reverse transcription-polymerase chain reaction, we have investigated the capacity for cytokine gene expression profile in ex vivo circulating CD4 + T cells from 20 patients with active pulmonary tuberculosis compared with that of 30 normal healthy tuberculin-positive volunteers. Venous blood samples were collected from the former prior to the initiation of chemotherapy. A significant increase in interleukin (IL-2) expression (p<0.001) and a significant decrease in IL-5 expression (p<0.0001) were observed in patients with tuberculosis but no differences were seen in the expression of IL-4 and interferon gamma between the two study groups. Our data support a TH 1-like immune response in active tuberculosis.
Persistent Identifierhttp://hdl.handle.net/10722/49094
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, CKWen_HK
dc.contributor.authorHo, Sen_HK
dc.contributor.authorChan, CHSen_HK
dc.contributor.authorChan, Jen_HK
dc.contributor.authorChoy, Den_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2008-06-12T06:34:17Z-
dc.date.available2008-06-12T06:34:17Z-
dc.date.issued1997en_HK
dc.identifier.citationChest, 1997, v. 111 n. 3, p. 606-611en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49094-
dc.description.abstractT lymphocytes, particularly CD4 + cells, are thought to play an important role in the immune defense against Mycobacterium tuberculosis through the release of their wide array of cytokines. In vitro studies suggest that Mycobacterium-specific T-cell clones are of the TH 1 subtype. Using the technique of reverse transcription-polymerase chain reaction, we have investigated the capacity for cytokine gene expression profile in ex vivo circulating CD4 + T cells from 20 patients with active pulmonary tuberculosis compared with that of 30 normal healthy tuberculin-positive volunteers. Venous blood samples were collected from the former prior to the initiation of chemotherapy. A significant increase in interleukin (IL-2) expression (p<0.001) and a significant decrease in IL-5 expression (p<0.0001) were observed in patients with tuberculosis but no differences were seen in the expression of IL-4 and interferon gamma between the two study groups. Our data support a TH 1-like immune response in active tuberculosis.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectcytokinesen_HK
dc.subjecthelper T cellsen_HK
dc.subjectinterleukin 2en_HK
dc.subjectT lymphocytesen_HK
dc.subjecttuberculosisen_HK
dc.titleCytokine gene expression profile of circulating CD4 + T cells in active pulmonary tuberculosisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=111&issue=3&spage=606&epage=611&date=1997&atitle=Cytokine+gene+expression+profile+of+circulating+CD4++T+cells+in+active+pulmonary+tuberculosisen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1378/chest.111.3.606en_HK
dc.identifier.pmid9118695-
dc.identifier.scopuseid_2-s2.0-0030939026en_HK
dc.identifier.hkuros41369-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030939026&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue3en_HK
dc.identifier.spage606en_HK
dc.identifier.epage611en_HK
dc.identifier.isiWOS:A1997WM94600016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, CKW=7403086390en_HK
dc.identifier.scopusauthoridHo, S=36839064900en_HK
dc.identifier.scopusauthoridChan, CHS=16169208100en_HK
dc.identifier.scopusauthoridChan, J=15041622900en_HK
dc.identifier.scopusauthoridChoy, D=14324272700en_HK
dc.identifier.scopusauthoridLeung, R=7101875690en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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