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Article: The Effect of Pseudomonas aeruginosa Infection on Clinical Parameters in Steady-State Bronchiectasis

TitleThe Effect of Pseudomonas aeruginosa Infection on Clinical Parameters in Steady-State Bronchiectasis
Authors
KeywordsBronchiectasis
Pseudomonas aeruginosa
Sputum pathogens
Issue Date1998
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 1998, v. 114 n. 6, p. 1594-1598 How to Cite?
AbstractStudy objective: To investigate the effect of Pseudomonas aeruginosa infection on clinical parameters in Chinese patients with noncystic fibrosis and steady-state bronchiectasis. Design: Prospective, cross-sectional clinicomicrobiological study with informed consent. Setting: Consecutive outpatient recruitment from a specialist bronchiectasis respiratory clinic. Patients: Outpatients (n = 100; 62 women; 55.1 ± 16.7 years old; FEV1/FVC 1.4 ± 0.7/2.1 ± 0.9 L), who had stable respiratory symptoms for more than 3 weeks. Measurements and results: Respiratory pathogens isolated from the sputum were: Pseudomonas aeruginosa (33), Haemophilus influenzae (10), Moraxella catarrhalis (2), other Gram-negative bacilli (5), Streptococcus pneumoniae (6), Staphylococcus aureus (5), mycobacteria (3), and yeast (1). Clinical parameters in patients with positive isolation of P aeruginosa were compared with those without the organism in the sputum culture (non-P aeruginosa). In the P aeruginosa group, the FEV1/FVC ratio and sputum volume were lower (p < 0.005) and higher (p < 0.0001), respectively, than those of the non-P aeruginosa group. The FEV1/FVC ratio (< 60%) and sputum volume (grading > 5) were independently associated with a positive sputum isolation of P aeruginosa with odds ratios of 3.1 (confidence interval [CI] 1.2 to 8.4; p < 0.01) and 4.7 (CI 1.6 to 13.3; p < 0.001), respectively. Conclusions: P aeruginosa is the predominant respiratory pathogen isolated in the sputum of Chinese patients with steady-state bronchiectasis, and its isolation is associated with high sputum output (≥ 75th quartile) and moderately severe airflow obstruction (FEV1/FVC < 60%).
Persistent Identifierhttp://hdl.handle.net/10722/49086
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, PLen_HK
dc.contributor.authorChan, KNen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorHo, CSen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2008-06-12T06:34:06Z-
dc.date.available2008-06-12T06:34:06Z-
dc.date.issued1998en_HK
dc.identifier.citationChest, 1998, v. 114 n. 6, p. 1594-1598en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49086-
dc.description.abstractStudy objective: To investigate the effect of Pseudomonas aeruginosa infection on clinical parameters in Chinese patients with noncystic fibrosis and steady-state bronchiectasis. Design: Prospective, cross-sectional clinicomicrobiological study with informed consent. Setting: Consecutive outpatient recruitment from a specialist bronchiectasis respiratory clinic. Patients: Outpatients (n = 100; 62 women; 55.1 ± 16.7 years old; FEV1/FVC 1.4 ± 0.7/2.1 ± 0.9 L), who had stable respiratory symptoms for more than 3 weeks. Measurements and results: Respiratory pathogens isolated from the sputum were: Pseudomonas aeruginosa (33), Haemophilus influenzae (10), Moraxella catarrhalis (2), other Gram-negative bacilli (5), Streptococcus pneumoniae (6), Staphylococcus aureus (5), mycobacteria (3), and yeast (1). Clinical parameters in patients with positive isolation of P aeruginosa were compared with those without the organism in the sputum culture (non-P aeruginosa). In the P aeruginosa group, the FEV1/FVC ratio and sputum volume were lower (p < 0.005) and higher (p < 0.0001), respectively, than those of the non-P aeruginosa group. The FEV1/FVC ratio (< 60%) and sputum volume (grading > 5) were independently associated with a positive sputum isolation of P aeruginosa with odds ratios of 3.1 (confidence interval [CI] 1.2 to 8.4; p < 0.01) and 4.7 (CI 1.6 to 13.3; p < 0.001), respectively. Conclusions: P aeruginosa is the predominant respiratory pathogen isolated in the sputum of Chinese patients with steady-state bronchiectasis, and its isolation is associated with high sputum output (≥ 75th quartile) and moderately severe airflow obstruction (FEV1/FVC < 60%).en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBronchiectasisen_HK
dc.subjectPseudomonas aeruginosaen_HK
dc.subjectSputum pathogensen_HK
dc.titleThe Effect of Pseudomonas aeruginosa Infection on Clinical Parameters in Steady-State Bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=114&issue=6&spage=1594&epage=1598&date=1998&atitle=The+effect+of+Pseudomonas+aeruginosa+infection+on+clinical+parameters+in+steady-state+bronchiectasisen_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1378/chest.114.6.1594en_HK
dc.identifier.pmid9872194-
dc.identifier.scopuseid_2-s2.0-0032253292en_HK
dc.identifier.hkuros39370-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032253292&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume114en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1594en_HK
dc.identifier.epage1598en_HK
dc.identifier.isiWOS:000077613600021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridChan, KN=15737866400en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridHo, CS=36986008400en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK

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