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Article: High seroprevalence of Helicobacter pylori in active bronchiectasis

TitleHigh seroprevalence of Helicobacter pylori in active bronchiectasis
Authors
Issue Date1998
PublisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.org
Citation
American Journal Of Respiratory And Critical Care Medicine, 1998, v. 158 n. 4, p. 1047-1051 How to Cite?
AbstractHelicobacter pylori causes chronic inflammation of the gastric mucosa and has been identified in tracheobronchial secretions. Serum IgG against H. pylori was therefore measured prospectively in consecutive subjects with bronchiectasis (n - 100; mean age + SD 55.1 + 16.7 yr), active pulmonary tuberculosis (n - 87; age, 57.3 + 19.1 yr), and healthy volunteers (n - 94; age, 54.6 + 7.6 yr). Seropositivity was found in 76.0% of bronchiectatic subjects, which was significantly higher than that of the control (54.3%, p - 0.001) and tuberculous (52.9%, p = 0.0001) groups. Multiple logistic regression, adjusted for age, sex, occupational social class, and number of persons living in the house-hold, showed that H. pylori IgG levels of the bronchiectatic group were still significantly higher than that of the control (p = 0.0014) and tuberculous (p = 0.0154) groups. Multiple regression analysis revealed associations between H. pylori serology and sputum volume (p = 0.03) and age (p = 0.001) in the bronchiectatic patients, but not lung function indices or causes of bronchiectasis. The H. pylori seroprevalence in bronchiectasis was significantly (p = 0.0002) higher in patients who produced more (83.1%) than those who produced less than 5 ml sputum/24 h (58.6%). This is the first report of a high H. pylori seroprevalence in bronchiectasis which appears to be specific. Further studies are indicated to evaluate the possible pathogenic role of H. pylori in bronchiectasis.
Persistent Identifierhttp://hdl.handle.net/10722/49083
ISSN
2015 Impact Factor: 13.118
2015 SCImago Journal Rankings: 5.832
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorKarlberg, Jen_HK
dc.contributor.authorWong, BCen_HK
dc.contributor.authorHu, WHen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorIp, MSen_HK
dc.date.accessioned2008-06-12T06:34:02Z-
dc.date.available2008-06-12T06:34:02Z-
dc.date.issued1998en_HK
dc.identifier.citationAmerican Journal Of Respiratory And Critical Care Medicine, 1998, v. 158 n. 4, p. 1047-1051en_HK
dc.identifier.issn1073-449Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49083-
dc.description.abstractHelicobacter pylori causes chronic inflammation of the gastric mucosa and has been identified in tracheobronchial secretions. Serum IgG against H. pylori was therefore measured prospectively in consecutive subjects with bronchiectasis (n - 100; mean age + SD 55.1 + 16.7 yr), active pulmonary tuberculosis (n - 87; age, 57.3 + 19.1 yr), and healthy volunteers (n - 94; age, 54.6 + 7.6 yr). Seropositivity was found in 76.0% of bronchiectatic subjects, which was significantly higher than that of the control (54.3%, p - 0.001) and tuberculous (52.9%, p = 0.0001) groups. Multiple logistic regression, adjusted for age, sex, occupational social class, and number of persons living in the house-hold, showed that H. pylori IgG levels of the bronchiectatic group were still significantly higher than that of the control (p = 0.0014) and tuberculous (p = 0.0154) groups. Multiple regression analysis revealed associations between H. pylori serology and sputum volume (p = 0.03) and age (p = 0.001) in the bronchiectatic patients, but not lung function indices or causes of bronchiectasis. The H. pylori seroprevalence in bronchiectasis was significantly (p = 0.0002) higher in patients who produced more (83.1%) than those who produced less than 5 ml sputum/24 h (58.6%). This is the first report of a high H. pylori seroprevalence in bronchiectasis which appears to be specific. Further studies are indicated to evaluate the possible pathogenic role of H. pylori in bronchiectasis.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Thoracic Society. The Journal's web site is located at http://ajrccm.atsjournals.orgen_HK
dc.relation.ispartofAmerican Journal of Respiratory and Critical Care Medicineen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBronchiectasis - immunology - microbiologyen_HK
dc.subject.meshHelicobacter Infections - diagnosis - immunologyen_HK
dc.subject.meshHelicobacter pylori - immunology - isolation & purificationen_HK
dc.subject.meshAntibodies, Bacterial - blooden_HK
dc.subject.meshForced Expiratory Volume - physiologyen_HK
dc.titleHigh seroprevalence of Helicobacter pylori in active bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1073-449X&volume=158&issue=4&spage=1047&epage=1051&date=1998&atitle=High+Seroprevalence+of+Helicobacter+pylori+in+Active+Bronchiectasisen_HK
dc.identifier.emailKarlberg, J: jpekarl@hkucc.hku.hken_HK
dc.identifier.emailWong, BC: bcywong@hku.hken_HK
dc.identifier.emailIp, MS: msmip@hku.hken_HK
dc.identifier.authorityKarlberg, J=rp00400en_HK
dc.identifier.authorityWong, BC=rp00429en_HK
dc.identifier.authorityIp, MS=rp00347en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9769259-
dc.identifier.scopuseid_2-s2.0-0031739480en_HK
dc.identifier.hkuros39135-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031739480&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume158en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1047en_HK
dc.identifier.epage1051en_HK
dc.identifier.isiWOS:000076453300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK
dc.identifier.scopusauthoridLam, SK=55424391900en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridKarlberg, J=7005218406en_HK
dc.identifier.scopusauthoridWong, BC=7402023340en_HK
dc.identifier.scopusauthoridHu, WH=25932937100en_HK
dc.identifier.scopusauthoridYew, WW=7005934631en_HK
dc.identifier.scopusauthoridIp, MS=7102423259en_HK

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