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Article: Neuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in rats

TitleNeuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in rats
Authors
KeywordsAntisense oligodeoxynucleotide
Neuropeptide Y
Neuropeptide Y receptor
Neuroprotection
Stroke
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2000, v. 98 n. 4, p. 771-777 How to Cite?
AbstractAn antisense oligodeoxynucleotide selective for the rat neuropeptide Y1 receptor gene was given into the left lateral ventricle in the experimental group of rats, whereas a missense oligodeoxynucleotide or saline was given in the control groups. Some rats were decapitated at 1-2h after the last injection of the oligodeoxynucleotides to examine their effects on the Y1 receptor density in the insular cortex. When compared to the Y1 and Y2 binding density of the untreated rats, the antisense-treated rats had reduced Y1 binding in the insular cortex but the Y2 binding was unaffected; treatment with missense oligodeoxynucleotide had no effect. Other rats underwent a right-sided middle cerebral artery occlusion at 1-2h after the last injection of the oligodeoxynucleotides or saline to examine the effect on the infarction volume at three days following stroke. The antisense treatment resulted in a doubling of the mean infarction volume when compared to the missense or saline treatment.Thus, reducing the Y1 receptor density prior to middle cerebral artery occlusion is harmful. Neuropeptide Y may mediate neuroprotection against focal ischemia via the cortical Y1 receptor, since the immunoreactivity for neuropeptide Y has been shown to increase within the peri-infarct cortex after middle cerebral artery occlusion. Copyright (C) 2000 IBRO.
Persistent Identifierhttp://hdl.handle.net/10722/49081
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, RTFen_HK
dc.contributor.authorCechetto, DFen_HK
dc.date.accessioned2008-06-12T06:34:00Z-
dc.date.available2008-06-12T06:34:00Z-
dc.date.issued2000en_HK
dc.identifier.citationNeuroscience, 2000, v. 98 n. 4, p. 771-777en_HK
dc.identifier.issn0306-4522en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49081-
dc.description.abstractAn antisense oligodeoxynucleotide selective for the rat neuropeptide Y1 receptor gene was given into the left lateral ventricle in the experimental group of rats, whereas a missense oligodeoxynucleotide or saline was given in the control groups. Some rats were decapitated at 1-2h after the last injection of the oligodeoxynucleotides to examine their effects on the Y1 receptor density in the insular cortex. When compared to the Y1 and Y2 binding density of the untreated rats, the antisense-treated rats had reduced Y1 binding in the insular cortex but the Y2 binding was unaffected; treatment with missense oligodeoxynucleotide had no effect. Other rats underwent a right-sided middle cerebral artery occlusion at 1-2h after the last injection of the oligodeoxynucleotides or saline to examine the effect on the infarction volume at three days following stroke. The antisense treatment resulted in a doubling of the mean infarction volume when compared to the missense or saline treatment.Thus, reducing the Y1 receptor density prior to middle cerebral artery occlusion is harmful. Neuropeptide Y may mediate neuroprotection against focal ischemia via the cortical Y1 receptor, since the immunoreactivity for neuropeptide Y has been shown to increase within the peri-infarct cortex after middle cerebral artery occlusion. Copyright (C) 2000 IBRO.en_HK
dc.format.extent420 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_HK
dc.relation.ispartofNeuroscienceen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsNeuroscience. Copyright © Elsevier BV.en_HK
dc.subjectAntisense oligodeoxynucleotideen_HK
dc.subjectNeuropeptide Yen_HK
dc.subjectNeuropeptide Y receptoren_HK
dc.subjectNeuroprotectionen_HK
dc.subjectStrokeen_HK
dc.titleNeuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-4522&volume=98&issue=4&spage=771&epage=777&date=2000&atitle=Neuropeptide+Y-Y1+receptor+antisense+oligodeoxynucleotide+increases+the+infarct+volume+after+middle+cerebral+artery+occlusion+in+ratsen_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1016/S0306-4522(00)00159-7en_HK
dc.identifier.pmid10891620-
dc.identifier.scopuseid_2-s2.0-0034124503en_HK
dc.identifier.hkuros37639-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034124503&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume98en_HK
dc.identifier.issue4en_HK
dc.identifier.spage771en_HK
dc.identifier.epage777en_HK
dc.identifier.isiWOS:000088427200016-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.identifier.scopusauthoridCechetto, DF=7006226109en_HK

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