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Article: Heparin therapy in the Chinese--lower doses are required

TitleHeparin therapy in the Chinese--lower doses are required
Authors
Issue Date1997
PublisherOxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/
Citation
Q J M, 1997, v. 90 n. 8, p. 535-543 How to Cite?
AbstractWarfarin requirements are lower in the Chinese, but it is not known if this applies to heparin. We investigated the optimal dose for heparin therapy in Chinese patients, and to assess relationship between i.v. heparin dosage and anticoagulation efficacy. One hundred Chinese patients requiring intravenous heparin therapy were given an initial bolus followed by continuous intravenous infusion. The main outcome measures were: (i) Efficacy of anticoagulation assessed by blood coagulation studies (APTT) compared to heparin dosage, (ii) Determinants of dosage variation-age, gender, body weight, height, indication for heparin therapy and number of medications, other disease, and serum albumin level. It was found that the mean therapeutic infusion dose requirement of heparin was 848.7 +/- 274.7 units/h, 79% required a dose of 1000 units/h or less. Heparin dose correlated negatively with age (r = -0.40; p < 0.001) and positively with weight (r = 0.44 p < 0.001) and height (r = 0.49; p < 0.001). Chinese subjects require lower heparin doses (about 800 units/h) than usually recommended for Caucasians (usual dose 1000-1500 units/h). This can be partly explained by the lower body weight in Chinese patients.
Persistent Identifierhttp://hdl.handle.net/10722/49078
ISSN
2015 Impact Factor: 2.824
2015 SCImago Journal Rankings: 0.633
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, CMen_HK
dc.contributor.authorChan, TYen_HK
dc.contributor.authorTsoi, WCen_HK
dc.contributor.authorSanderson, JEen_HK
dc.date.accessioned2008-06-12T06:33:56Z-
dc.date.available2008-06-12T06:33:56Z-
dc.date.issued1997en_HK
dc.identifier.citationQ J M, 1997, v. 90 n. 8, p. 535-543en_HK
dc.identifier.issn1460-2725en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49078-
dc.description.abstractWarfarin requirements are lower in the Chinese, but it is not known if this applies to heparin. We investigated the optimal dose for heparin therapy in Chinese patients, and to assess relationship between i.v. heparin dosage and anticoagulation efficacy. One hundred Chinese patients requiring intravenous heparin therapy were given an initial bolus followed by continuous intravenous infusion. The main outcome measures were: (i) Efficacy of anticoagulation assessed by blood coagulation studies (APTT) compared to heparin dosage, (ii) Determinants of dosage variation-age, gender, body weight, height, indication for heparin therapy and number of medications, other disease, and serum albumin level. It was found that the mean therapeutic infusion dose requirement of heparin was 848.7 +/- 274.7 units/h, 79% required a dose of 1000 units/h or less. Heparin dose correlated negatively with age (r = -0.40; p < 0.001) and positively with weight (r = 0.44 p < 0.001) and height (r = 0.49; p < 0.001). Chinese subjects require lower heparin doses (about 800 units/h) than usually recommended for Caucasians (usual dose 1000-1500 units/h). This can be partly explained by the lower body weight in Chinese patients.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnticoagulants - administration & dosageen_HK
dc.subject.meshBlood Coagulation Disorders - drug therapy - metabolismen_HK
dc.subject.meshHeparin - administration & dosageen_HK
dc.subject.meshThrombolytic Therapyen_HK
dc.subject.meshDrug Administration Scheduleen_HK
dc.titleHeparin therapy in the Chinese--lower doses are requireden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1460-2725&volume=90&issue=8&spage=535&epage=543&date=1997&atitle=Heparin+therapy+in+the+Chinese--lower+doses+are+requireden_HK
dc.identifier.emailYu, CM: cymua@hkucc.hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1093/qjmed/90.8.535en_HK
dc.identifier.pmid9327033en_HK
dc.identifier.hkuros35475-
dc.identifier.isiWOS:A1997XQ87600008-

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