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- Publisher Website: 10.1210/jcem.83.1.4491
- Scopus: eid_2-s2.0-0031768732
- PMID: 9435431
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Article: Plasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism
Title | Plasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism |
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Authors | |
Issue Date | 1998 |
Publisher | The Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org |
Citation | Journal of Clinical Endocrinology and Metabolism, 1998, v. 83 n. 1, p. 140-143 How to Cite? |
Abstract | Thyroid dysfunction is associated with multiple changes in lipoprotein metabolism, and we have determined the effects of thyroid dysfunction on plasma cholesteryl ester transfer protein (CETP) activity. CETP is a plasma protein that mediates the exchange of cholesteryl ester and triglyceride between plasma lipoproteins and plays an important role in high-density lipoprotein metabolism and in the reverse cholesterol transport pathway. Plasma CETP activity was assayed in 18 hyperthyroid and in 17 hypothyroid patients, before and after treatment, by measuring the transfer of cholesteryl esters from exogenous radiolabeled high-density lipoprotein to apolipoprotein B-containing lipoproteins. Plasma CETP activity was increased in hyperthyroid patients, compared with their matched controls (22.11 ± 8.92% transferred/5 μL·4 h vs. 16.75 ± 6.48, P < 0.05), whereas in hypothyroid patients, plasma CETP activity was decreased (11.14 ± 4.84% transferred/5 μL·4 h vs. 17.26 ± 7.13, P < 0.01). Plasma CETP activity decreased after treatment of thyrotoxicosis, although a significant change was observed, mainly in the severely thyrotoxic patients with free T4 > 100 pmol/L (n = 11, 25.61 ± 8.12% transferred/5 μL·4 h vs. 21.71 ± 7.84, P < 0.05). In the hypothyroid patients, there was a significant increase in plasma CETP activity after thyroxine replacement (11.14 ± 4.84% transferred/5 μL·4 h vs. 15.46 ± 6.71, P < 0.01). There was a strong positive correlation between log(free T4) and plasma CETP activity (r = 0.51, P < 0.001). In summary, both hyper- and hypothyroidism are associated with significant changes in plasma CETP activity, and these changes are corrected when the patients have been rendered euthyroid. |
Persistent Identifier | http://hdl.handle.net/10722/49075 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 1.899 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tan, KCB | en_HK |
dc.contributor.author | Shiu, SWM | en_HK |
dc.contributor.author | Kung, AWC | en_HK |
dc.date.accessioned | 2008-06-12T06:33:52Z | - |
dc.date.available | 2008-06-12T06:33:52Z | - |
dc.date.issued | 1998 | en_HK |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 1998, v. 83 n. 1, p. 140-143 | en_HK |
dc.identifier.issn | 0021-972X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/49075 | - |
dc.description.abstract | Thyroid dysfunction is associated with multiple changes in lipoprotein metabolism, and we have determined the effects of thyroid dysfunction on plasma cholesteryl ester transfer protein (CETP) activity. CETP is a plasma protein that mediates the exchange of cholesteryl ester and triglyceride between plasma lipoproteins and plays an important role in high-density lipoprotein metabolism and in the reverse cholesterol transport pathway. Plasma CETP activity was assayed in 18 hyperthyroid and in 17 hypothyroid patients, before and after treatment, by measuring the transfer of cholesteryl esters from exogenous radiolabeled high-density lipoprotein to apolipoprotein B-containing lipoproteins. Plasma CETP activity was increased in hyperthyroid patients, compared with their matched controls (22.11 ± 8.92% transferred/5 μL·4 h vs. 16.75 ± 6.48, P < 0.05), whereas in hypothyroid patients, plasma CETP activity was decreased (11.14 ± 4.84% transferred/5 μL·4 h vs. 17.26 ± 7.13, P < 0.01). Plasma CETP activity decreased after treatment of thyrotoxicosis, although a significant change was observed, mainly in the severely thyrotoxic patients with free T4 > 100 pmol/L (n = 11, 25.61 ± 8.12% transferred/5 μL·4 h vs. 21.71 ± 7.84, P < 0.05). In the hypothyroid patients, there was a significant increase in plasma CETP activity after thyroxine replacement (11.14 ± 4.84% transferred/5 μL·4 h vs. 15.46 ± 6.71, P < 0.01). There was a strong positive correlation between log(free T4) and plasma CETP activity (r = 0.51, P < 0.001). In summary, both hyper- and hypothyroidism are associated with significant changes in plasma CETP activity, and these changes are corrected when the patients have been rendered euthyroid. | en_HK |
dc.format.extent | 418 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | eng | en_HK |
dc.publisher | The Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org | en_HK |
dc.relation.ispartof | Journal of Clinical Endocrinology and Metabolism | en_HK |
dc.subject.mesh | Carrier Proteins - blood | en_HK |
dc.subject.mesh | Glycoproteins | en_HK |
dc.subject.mesh | Graves Disease - blood - drug therapy | en_HK |
dc.subject.mesh | Hypothyroidism - blood - drug therapy - etiology | en_HK |
dc.subject.mesh | Antithyroid Agents - therapeutic use | en_HK |
dc.title | Plasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Tan, KCB:kcbtan@hku.hk | en_HK |
dc.identifier.email | Kung, AWC:awckung@hku.hk | en_HK |
dc.identifier.authority | Tan, KCB=rp00402 | en_HK |
dc.identifier.authority | Kung, AWC=rp00368 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_HK |
dc.identifier.doi | 10.1210/jcem.83.1.4491 | en_HK |
dc.identifier.pmid | 9435431 | - |
dc.identifier.scopus | eid_2-s2.0-0031768732 | en_HK |
dc.identifier.hkuros | 33940 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0031768732&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 83 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 140 | en_HK |
dc.identifier.epage | 143 | en_HK |
dc.identifier.isi | WOS:000071270600026 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Tan, KCB=8082703100 | en_HK |
dc.identifier.scopusauthorid | Shiu, SWM=7005550652 | en_HK |
dc.identifier.scopusauthorid | Kung, AWC=7102322339 | en_HK |
dc.identifier.issnl | 0021-972X | - |