File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Plasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism

TitlePlasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism
Authors
Issue Date1998
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 1, p. 140-143 How to Cite?
AbstractThyroid dysfunction is associated with multiple changes in lipoprotein metabolism, and we have determined the effects of thyroid dysfunction on plasma cholesteryl ester transfer protein (CETP) activity. CETP is a plasma protein that mediates the exchange of cholesteryl ester and triglyceride between plasma lipoproteins and plays an important role in high-density lipoprotein metabolism and in the reverse cholesterol transport pathway. Plasma CETP activity was assayed in 18 hyperthyroid and in 17 hypothyroid patients, before and after treatment, by measuring the transfer of cholesteryl esters from exogenous radiolabeled high-density lipoprotein to apolipoprotein B-containing lipoproteins. Plasma CETP activity was increased in hyperthyroid patients, compared with their matched controls (22.11 ± 8.92% transferred/5 μL·4 h vs. 16.75 ± 6.48, P < 0.05), whereas in hypothyroid patients, plasma CETP activity was decreased (11.14 ± 4.84% transferred/5 μL·4 h vs. 17.26 ± 7.13, P < 0.01). Plasma CETP activity decreased after treatment of thyrotoxicosis, although a significant change was observed, mainly in the severely thyrotoxic patients with free T4 > 100 pmol/L (n = 11, 25.61 ± 8.12% transferred/5 μL·4 h vs. 21.71 ± 7.84, P < 0.05). In the hypothyroid patients, there was a significant increase in plasma CETP activity after thyroxine replacement (11.14 ± 4.84% transferred/5 μL·4 h vs. 15.46 ± 6.71, P < 0.01). There was a strong positive correlation between log(free T4) and plasma CETP activity (r = 0.51, P < 0.001). In summary, both hyper- and hypothyroidism are associated with significant changes in plasma CETP activity, and these changes are corrected when the patients have been rendered euthyroid.
Persistent Identifierhttp://hdl.handle.net/10722/49075
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorShiu, SWMen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2008-06-12T06:33:52Z-
dc.date.available2008-06-12T06:33:52Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 1998, v. 83 n. 1, p. 140-143en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49075-
dc.description.abstractThyroid dysfunction is associated with multiple changes in lipoprotein metabolism, and we have determined the effects of thyroid dysfunction on plasma cholesteryl ester transfer protein (CETP) activity. CETP is a plasma protein that mediates the exchange of cholesteryl ester and triglyceride between plasma lipoproteins and plays an important role in high-density lipoprotein metabolism and in the reverse cholesterol transport pathway. Plasma CETP activity was assayed in 18 hyperthyroid and in 17 hypothyroid patients, before and after treatment, by measuring the transfer of cholesteryl esters from exogenous radiolabeled high-density lipoprotein to apolipoprotein B-containing lipoproteins. Plasma CETP activity was increased in hyperthyroid patients, compared with their matched controls (22.11 ± 8.92% transferred/5 μL·4 h vs. 16.75 ± 6.48, P < 0.05), whereas in hypothyroid patients, plasma CETP activity was decreased (11.14 ± 4.84% transferred/5 μL·4 h vs. 17.26 ± 7.13, P < 0.01). Plasma CETP activity decreased after treatment of thyrotoxicosis, although a significant change was observed, mainly in the severely thyrotoxic patients with free T4 > 100 pmol/L (n = 11, 25.61 ± 8.12% transferred/5 μL·4 h vs. 21.71 ± 7.84, P < 0.05). In the hypothyroid patients, there was a significant increase in plasma CETP activity after thyroxine replacement (11.14 ± 4.84% transferred/5 μL·4 h vs. 15.46 ± 6.71, P < 0.01). There was a strong positive correlation between log(free T4) and plasma CETP activity (r = 0.51, P < 0.001). In summary, both hyper- and hypothyroidism are associated with significant changes in plasma CETP activity, and these changes are corrected when the patients have been rendered euthyroid.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.rightsJournal of Clinical Endocrinology and Metabolism. Copyright © The Endocrine Society.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarrier Proteins - blooden_HK
dc.subject.meshGlycoproteinsen_HK
dc.subject.meshGraves Disease - blood - drug therapyen_HK
dc.subject.meshHypothyroidism - blood - drug therapy - etiologyen_HK
dc.subject.meshAntithyroid Agents - therapeutic useen_HK
dc.titlePlasma cholesteryl ester transfer protein activity in hyper- and hypothyroidismen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=83&issue=1&spage=140&epage=143&date=1998&atitle=Plasma+cholesteryl+ester+transfer+protein+activity+in+hyper-+and+hypothyroidismen_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.emailKung, AWC:awckung@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1210/jc.83.1.140en_HK
dc.identifier.pmid9435431-
dc.identifier.scopuseid_2-s2.0-0031768732en_HK
dc.identifier.hkuros33940-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031768732&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue1en_HK
dc.identifier.spage140en_HK
dc.identifier.epage143en_HK
dc.identifier.isiWOS:000071270600026-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridShiu, SWM=7005550652en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats