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Article: Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer

TitleCombination therapy with suicide and cytokine genes for hepatic metastases of lung cancer
Authors
KeywordsAdenoviral vectors
Cytokine gene
Gene therapy
Liver metastases
Lung cancer
Suicide gene
Issue Date1997
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 1997, v. 112 n. 5, p. 1332-1337 How to Cite?
AbstractMetastases of lung cancer are a major cause of treatment failure. To evaluate the therapeutic efficacy of gene therapy in metastatic lung cancer, we used adenoviral (ADV) mediated transfer of the herpes simplex virus thymidine kinase (HSV-tk) gene and the cytokine gene interleukin-2 (IL-2) to treat a murine model of metastatic lung cancer in the liver. Hepatic metastases were established by intrahepatic implantation of LL2 cells in syngeneic recipient mice. One week after tumor implantation, various replication defective ADV vectors were injected intratumorally. Treatment with a vector expressing the HSV-tk followed by ganciclovir administration with ADV.tk resulted in significant regression of tumor (p<0.01) as well as prolongation of survival (p<0.001). While a vector expressing mouse IL-2 ADV.IL-2 alone was ineffective, combination therapy with HSV-tk resulted in further tumor regression and improvement of animal survival (p<0.05). These results demonstrate that suicide and cytokine genes can be utilized in combination to treat metastatic lung cancer in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/49074
ISSN
2015 Impact Factor: 5.94
2015 SCImago Journal Rankings: 3.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorChen, SHen_HK
dc.contributor.authorKosai, Ken_HK
dc.contributor.authorFinegold, Men_HK
dc.contributor.authorWoo, SLCen_HK
dc.date.accessioned2008-06-12T06:33:50Z-
dc.date.available2008-06-12T06:33:50Z-
dc.date.issued1997en_HK
dc.identifier.citationChest, 1997, v. 112 n. 5, p. 1332-1337en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49074-
dc.description.abstractMetastases of lung cancer are a major cause of treatment failure. To evaluate the therapeutic efficacy of gene therapy in metastatic lung cancer, we used adenoviral (ADV) mediated transfer of the herpes simplex virus thymidine kinase (HSV-tk) gene and the cytokine gene interleukin-2 (IL-2) to treat a murine model of metastatic lung cancer in the liver. Hepatic metastases were established by intrahepatic implantation of LL2 cells in syngeneic recipient mice. One week after tumor implantation, various replication defective ADV vectors were injected intratumorally. Treatment with a vector expressing the HSV-tk followed by ganciclovir administration with ADV.tk resulted in significant regression of tumor (p<0.01) as well as prolongation of survival (p<0.001). While a vector expressing mouse IL-2 ADV.IL-2 alone was ineffective, combination therapy with HSV-tk resulted in further tumor regression and improvement of animal survival (p<0.05). These results demonstrate that suicide and cytokine genes can be utilized in combination to treat metastatic lung cancer in vivo.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAdenoviral vectorsen_HK
dc.subjectCytokine geneen_HK
dc.subjectGene therapyen_HK
dc.subjectLiver metastasesen_HK
dc.subjectLung canceren_HK
dc.subjectSuicide geneen_HK
dc.titleCombination therapy with suicide and cytokine genes for hepatic metastases of lung canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-3692&volume=112&issue=5&spage=1332&epage=1337&date=1997&atitle=Combination+therapy+with+suicide+and+cytokine+genes+for+hepatic+metastases+of+lung+canceren_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1378/chest.112.5.1332en_HK
dc.identifier.pmid9367477-
dc.identifier.scopuseid_2-s2.0-0030701975en_HK
dc.identifier.hkuros33342-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030701975&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume112en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1332en_HK
dc.identifier.epage1337en_HK
dc.identifier.isiWOS:A1997YF05200031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridChen, SH=7410253435en_HK
dc.identifier.scopusauthoridKosai, K=35463991100en_HK
dc.identifier.scopusauthoridFinegold, M=7006478991en_HK
dc.identifier.scopusauthoridWoo, SLC=7402853378en_HK

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