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Article: Isolated extramedullary relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia

TitleIsolated extramedullary relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia
Authors
Au, WYChan, ACLLie, AKWSo, JCCLiang, RKwong, YL
KeywordsBone marrow transplantation
Chronic myeloid leukemia
Granulocytic sarcoma
Issue Date1998
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 1998, v. 22 n. 1, p. 99-102 How to Cite?
DOI: http://dx.doi.org/10.1038/sj.bmt.1701294
AbstractRelapse of chronic myeloid leukemia (CML) as extramedullary granulocytic sarcoma (GS) after allogeneic bone marrow transplantation (BMT) is a rare occurrence. We report two patients who developed spinal GS as the first indication of relapse after allogeneic BMT for CML. In both cases, the marrow was in morphologic and karyotypic remission. However, fluorescence in situ hybridization (FISH) successfully demonstrated the presence of a minor Ph-positive clone in the marrow, as well as an occult clone with an additional Ph chromosome detected in one case. The results indicated a stronger graft-versus-leukemia effect in the marrow than in the peripheral tissues.
Persistent Identifierhttp://hdl.handle.net/10722/49073
ISSN
0268-3369
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.318
ISI Accession Number ID
WOS:000074582700016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorChan, ACLen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorSo, JCCen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2008-06-12T06:33:49Z-
dc.date.available2008-06-12T06:33:49Z-
dc.date.issued1998en_HK
dc.identifier.citationBone Marrow Transplantation, 1998, v. 22 n. 1, p. 99-102en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49073-
dc.description.abstractRelapse of chronic myeloid leukemia (CML) as extramedullary granulocytic sarcoma (GS) after allogeneic bone marrow transplantation (BMT) is a rare occurrence. We report two patients who developed spinal GS as the first indication of relapse after allogeneic BMT for CML. In both cases, the marrow was in morphologic and karyotypic remission. However, fluorescence in situ hybridization (FISH) successfully demonstrated the presence of a minor Ph-positive clone in the marrow, as well as an occult clone with an additional Ph chromosome detected in one case. The results indicated a stronger graft-versus-leukemia effect in the marrow than in the peripheral tissues.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.subjectBone marrow transplantationen_HK
dc.subjectChronic myeloid leukemiaen_HK
dc.subjectGranulocytic sarcomaen_HK
dc.titleIsolated extramedullary relapse after allogeneic bone marrow transplantation for chronic myeloid leukemiaen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, JCC:scc@pathology.hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authoritySo, JCC=rp00391en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1038/sj.bmt.1701294en_HK
dc.identifier.pmid9678803-
dc.identifier.scopuseid_2-s2.0-0031825582en_HK
dc.identifier.hkuros33136-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031825582&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue1en_HK
dc.identifier.spage99en_HK
dc.identifier.epage102en_HK
dc.identifier.isiWOS:000074582700016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridChan, ACL=16047349300en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridSo, JCC=7102919978en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0268-3369-

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