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Article: Effect of age on the characteristics and clinical behavior of non-Hodgkin's lymphoma patients

TitleEffect of age on the characteristics and clinical behavior of non-Hodgkin's lymphoma patients
Authors
KeywordsAge
Elderly patients
Non-Hodgkin's lymphoma
Issue Date1997
PublisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/
Citation
Annals of Oncology, 1997, v. 8 n. 10, p. 973-978 How to Cite?
AbstractBACKGROUND: The goals of this study are to describe the frequency, clinical characteristics, and outcome of the different non-Hodgkin's lymphomas according to age. PATIENTS AND METHODS: Patients included in the recently published analysis of the Non-Hodgkin's Lymphoma Classification Project were analyzed. All patients had their slides reviewed and classified by five independent expert hematopathologists. Lymphomas were classified according to the Revised European American Classification of lymphoid neoplasms. Sufficient data were available on 1283 cases. Five age groups were analyzed: < 35 years, 35-49 years, 50-59 years, 60-69 years, and > or = 70 years. RESULTS: Few differences were observed between the age groups with regard to lymphoma types and clinical characteristics. Anaplastic large cell lymphoma, Burkitt's lymphoma, and lymphoblastic lymphoma were observed more frequently in patients younger than 35 years, whereas small lymphocytic and lymphoplasmacytoid lymphomas were observed more frequently in patients older than 70 years. Mantle cell lymphoma and marginal zone lymphomas were observed more frequently in middle-aged patients. Poor performance status was more frequent in older patients, as was bone marrow infiltration, whereas spleen involvement was more frequent in younger patients. Young and older patients had a slightly worse age-adjusted International Prognostic Index score (P < 0.01). Complete response rates decreased with age from 68% in the youngest patients to 45% in the oldest patients (P < 0.0001). Median event-free survival and overall survival also decreased with age (P < 0.0001). CONCLUSIONS: Elderly patients have a poorer outcome than younger patients but age alone is not sufficient to discriminate patients with a poor outcome. However, the histologic type of lymphoma and clinical characteristics may define a subgroup of patients with a poor outcome in each age category.
DescriptionThe Non-Hodgkin's Lymphoma Classification Project
Persistent Identifierhttp://hdl.handle.net/10722/49066
ISSN
2015 Impact Factor: 9.269
2015 SCImago Journal Rankings: 4.362

 

DC FieldValueLanguage
dc.contributor.authorAnderson, JRen_HK
dc.contributor.authorArmitage, JOen_HK
dc.contributor.authorBerger, Fen_HK
dc.contributor.authorCavalli, Fen_HK
dc.contributor.authorChan, WCen_HK
dc.contributor.authorClose, Jen_HK
dc.contributor.authorCoiffier, Ben_HK
dc.contributor.authorConnors, Jen_HK
dc.contributor.authorDiebold, Jen_HK
dc.contributor.authorGascoyne, Ren_HK
dc.contributor.authorHarris, Nen_HK
dc.contributor.authorHiddemann, Wen_HK
dc.contributor.authorHo, Fen_HK
dc.contributor.authorJacobs, Pen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorLister, TAen_HK
dc.contributor.authorMacLennan, KAen_HK
dc.contributor.authorMuller-Hermelink, HKen_HK
dc.contributor.authorNathwani, BNen_HK
dc.contributor.authorNorton, Aen_HK
dc.contributor.authorOtt, Gen_HK
dc.contributor.authorPedrinis, Een_HK
dc.contributor.authorRoy, Pen_HK
dc.contributor.authorSchauer, Aen_HK
dc.contributor.authorWeisenburger, DDen_HK
dc.date.accessioned2008-06-12T06:33:40Z-
dc.date.available2008-06-12T06:33:40Z-
dc.date.issued1997en_HK
dc.identifier.citationAnnals of Oncology, 1997, v. 8 n. 10, p. 973-978en_HK
dc.identifier.issn0923-7534en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49066-
dc.descriptionThe Non-Hodgkin's Lymphoma Classification Projecten_HK
dc.description.abstractBACKGROUND: The goals of this study are to describe the frequency, clinical characteristics, and outcome of the different non-Hodgkin's lymphomas according to age. PATIENTS AND METHODS: Patients included in the recently published analysis of the Non-Hodgkin's Lymphoma Classification Project were analyzed. All patients had their slides reviewed and classified by five independent expert hematopathologists. Lymphomas were classified according to the Revised European American Classification of lymphoid neoplasms. Sufficient data were available on 1283 cases. Five age groups were analyzed: < 35 years, 35-49 years, 50-59 years, 60-69 years, and > or = 70 years. RESULTS: Few differences were observed between the age groups with regard to lymphoma types and clinical characteristics. Anaplastic large cell lymphoma, Burkitt's lymphoma, and lymphoblastic lymphoma were observed more frequently in patients younger than 35 years, whereas small lymphocytic and lymphoplasmacytoid lymphomas were observed more frequently in patients older than 70 years. Mantle cell lymphoma and marginal zone lymphomas were observed more frequently in middle-aged patients. Poor performance status was more frequent in older patients, as was bone marrow infiltration, whereas spleen involvement was more frequent in younger patients. Young and older patients had a slightly worse age-adjusted International Prognostic Index score (P < 0.01). Complete response rates decreased with age from 68% in the youngest patients to 45% in the oldest patients (P < 0.0001). Median event-free survival and overall survival also decreased with age (P < 0.0001). CONCLUSIONS: Elderly patients have a poorer outcome than younger patients but age alone is not sufficient to discriminate patients with a poor outcome. However, the histologic type of lymphoma and clinical characteristics may define a subgroup of patients with a poor outcome in each age category.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAgeen_HK
dc.subjectElderly patientsen_HK
dc.subjectNon-Hodgkin's lymphomaen_HK
dc.titleEffect of age on the characteristics and clinical behavior of non-Hodgkin's lymphoma patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0923-7534&volume=8&issue=10&spage=973&epage=978&date=1997&atitle=Effect+of+age+on+the+characteristics+and+clinical+behavior+of+non-Hodgkin%27s+lymphoma+patientsen_HK
dc.identifier.emailHo, F: faithho@hkucc.hku.hken_HK
dc.identifier.emailLiang, R: rliang@hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1023/A:1008205619617-
dc.identifier.pmid9402170-
dc.identifier.scopuseid_2-s2.0-0030659105-
dc.identifier.hkuros28847-

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