Article: Effect of age on the characteristics and clinical behavior of non-Hodgkin's lymphoma patients

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TitleEffect of age on the characteristics and clinical behavior of non-Hodgkin's lymphoma patients
AuthorsAnderson, JR
Armitage, JO
Berger, F
Cavalli, F
Chan, WC
Close, J
Coiffier, B
Connors, J
Diebold, J
Gascoyne, R
Harris, N
Hiddemann, W
Ho, F
Jacobs, P
Liang, R
Lister, TA
MacLennan, KA
Muller-Hermelink, HK
Nathwani, BN
Norton, A
Ott, G
Pedrinis, E
Roy, P
Schauer, A
Weisenburger, DD
KeywordsAge
Elderly patients
Non-Hodgkin's lymphoma
Issue Date1997
PublisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/
CitationAnnals of Oncology, 1997, v. 8 n. 10, p. 973-978 [How to Cite?]
DOI: http://dx.doi.org/10.1023/A:1008205619617
AbstractBACKGROUND: The goals of this study are to describe the frequency, clinical characteristics, and outcome of the different non-Hodgkin's lymphomas according to age. PATIENTS AND METHODS: Patients included in the recently published analysis of the Non-Hodgkin's Lymphoma Classification Project were analyzed. All patients had their slides reviewed and classified by five independent expert hematopathologists. Lymphomas were classified according to the Revised European American Classification of lymphoid neoplasms. Sufficient data were available on 1283 cases. Five age groups were analyzed: < 35 years, 35-49 years, 50-59 years, 60-69 years, and > or = 70 years. RESULTS: Few differences were observed between the age groups with regard to lymphoma types and clinical characteristics. Anaplastic large cell lymphoma, Burkitt's lymphoma, and lymphoblastic lymphoma were observed more frequently in patients younger than 35 years, whereas small lymphocytic and lymphoplasmacytoid lymphomas were observed more frequently in patients older than 70 years. Mantle cell lymphoma and marginal zone lymphomas were observed more frequently in middle-aged patients. Poor performance status was more frequent in older patients, as was bone marrow infiltration, whereas spleen involvement was more frequent in younger patients. Young and older patients had a slightly worse age-adjusted International Prognostic Index score (P < 0.01). Complete response rates decreased with age from 68% in the youngest patients to 45% in the oldest patients (P < 0.0001). Median event-free survival and overall survival also decreased with age (P < 0.0001). CONCLUSIONS: Elderly patients have a poorer outcome than younger patients but age alone is not sufficient to discriminate patients with a poor outcome. However, the histologic type of lymphoma and clinical characteristics may define a subgroup of patients with a poor outcome in each age category.
DescriptionThe Non-Hodgkin's Lymphoma Classification Project
ISSN0923-7534
2011 Impact Factor: 6.425
2011 SCImago Journal Rankings: 0.541
DOIhttp://dx.doi.org/10.1023/A:1008205619617
DC Field
Value
dc.contributor.authorAnderson, JR
dc.contributor.authorArmitage, JO
dc.contributor.authorBerger, F
dc.contributor.authorCavalli, F
dc.contributor.authorChan, WC
dc.contributor.authorClose, J
dc.contributor.authorCoiffier, B
dc.contributor.authorConnors, J
dc.contributor.authorDiebold, J
dc.contributor.authorGascoyne, R
dc.contributor.authorHarris, N
dc.contributor.authorHiddemann, W
dc.contributor.authorHo, F
dc.contributor.authorJacobs, P
dc.contributor.authorLiang, R
dc.contributor.authorLister, TA
dc.contributor.authorMacLennan, KA
dc.contributor.authorMuller-Hermelink, HK
dc.contributor.authorNathwani, BN
dc.contributor.authorNorton, A
dc.contributor.authorOtt, G
dc.contributor.authorPedrinis, E
dc.contributor.authorRoy, P
dc.contributor.authorSchauer, A
dc.contributor.authorWeisenburger, DD
dc.date.accessioned2008-06-12T06:33:40Z
dc.date.available2008-06-12T06:33:40Z
dc.date.issued1997
dc.description.abstractBACKGROUND: The goals of this study are to describe the frequency, clinical characteristics, and outcome of the different non-Hodgkin's lymphomas according to age. PATIENTS AND METHODS: Patients included in the recently published analysis of the Non-Hodgkin's Lymphoma Classification Project were analyzed. All patients had their slides reviewed and classified by five independent expert hematopathologists. Lymphomas were classified according to the Revised European American Classification of lymphoid neoplasms. Sufficient data were available on 1283 cases. Five age groups were analyzed: < 35 years, 35-49 years, 50-59 years, 60-69 years, and > or = 70 years. RESULTS: Few differences were observed between the age groups with regard to lymphoma types and clinical characteristics. Anaplastic large cell lymphoma, Burkitt's lymphoma, and lymphoblastic lymphoma were observed more frequently in patients younger than 35 years, whereas small lymphocytic and lymphoplasmacytoid lymphomas were observed more frequently in patients older than 70 years. Mantle cell lymphoma and marginal zone lymphomas were observed more frequently in middle-aged patients. Poor performance status was more frequent in older patients, as was bone marrow infiltration, whereas spleen involvement was more frequent in younger patients. Young and older patients had a slightly worse age-adjusted International Prognostic Index score (P < 0.01). Complete response rates decreased with age from 68% in the youngest patients to 45% in the oldest patients (P < 0.0001). Median event-free survival and overall survival also decreased with age (P < 0.0001). CONCLUSIONS: Elderly patients have a poorer outcome than younger patients but age alone is not sufficient to discriminate patients with a poor outcome. However, the histologic type of lymphoma and clinical characteristics may define a subgroup of patients with a poor outcome in each age category.
dc.description.naturepublished_or_final_version
dc.descriptionThe Non-Hodgkin's Lymphoma Classification Project
dc.format.extent418 bytes
dc.format.mimetypetext/html
dc.identifier.citationAnnals of Oncology, 1997, v. 8 n. 10, p. 973-978 [How to Cite?]
DOI: http://dx.doi.org/10.1023/A:1008205619617
dc.identifier.doihttp://dx.doi.org/10.1023/A:1008205619617
dc.identifier.hkuros28847
dc.identifier.issn0923-7534
2011 Impact Factor: 6.425
2011 SCImago Journal Rankings: 0.541
dc.identifier.openurl
dc.identifier.pmid9402170
dc.identifier.scopuseid_2-s2.0-0030659105
dc.identifier.urihttp://hdl.handle.net/10722/49066
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://annonc.oxfordjournals.org/
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectAge
dc.subjectElderly patients
dc.subjectNon-Hodgkin's lymphoma
dc.titleEffect of age on the characteristics and clinical behavior of non-Hodgkin's lymphoma patients
dc.typeArticle
Author Affiliations
  1. Centre Hospitalier Lyon-Sud