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Conference Paper: Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma

TitleAdenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
Authors
KeywordsGene transfer
Cytokines
Recombinant adenoviral vectors
Issue Date1996
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
National Academy of Sciences Proceedings, 1996, v. 93 n. 21, p. 11302-11306 How to Cite?
AbstractRecombinant adenoviral mediated delivery of suicide and cytokine genes has been investigated as a treatment for hepatic metastases of colon carcinoma in mice. Liver tumors were established by intrahepatic implantation of a poorly immunogenic colon carcinoma cell line (MCA-26), which is syngeneic in BALB/c mice. Intratumoral transfer of the herpes simplex virus type 1 thymidine kinase (HSV-tk) and the murine interleukin (mIL)-2 genes resulted in substantial hepatic tumor regression, induced an effective systemic antitumoral immunity in the host and prolonged the median survival time of the treated animals from 22 to 35 days. The antitumoral immunity declined gradually, which led to tumor recurrence over time. A recombinant adenovirus expressing the mIL-12 gene was constructed and tested in the MCA-26 tumor model. Intratumoral administration of this cytokine vector alone increased significantly survival time of the animals with 25% of the treated animals still living over 70 days. These data indicate that local expression of IL-12 may also be an attractive treatment strategy for metastatic colon carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/49063
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCaruso, Men_HK
dc.contributor.authorNguyen, KPen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorXu, Ben_HK
dc.contributor.authorKosai, KIen_HK
dc.contributor.authorFinegold, Men_HK
dc.contributor.authorWoo, SLCen_HK
dc.contributor.authorChen, SHen_HK
dc.date.accessioned2008-06-12T06:33:36Z-
dc.date.available2008-06-12T06:33:36Z-
dc.date.issued1996en_HK
dc.identifier.citationNational Academy of Sciences Proceedings, 1996, v. 93 n. 21, p. 11302-11306en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49063-
dc.description.abstractRecombinant adenoviral mediated delivery of suicide and cytokine genes has been investigated as a treatment for hepatic metastases of colon carcinoma in mice. Liver tumors were established by intrahepatic implantation of a poorly immunogenic colon carcinoma cell line (MCA-26), which is syngeneic in BALB/c mice. Intratumoral transfer of the herpes simplex virus type 1 thymidine kinase (HSV-tk) and the murine interleukin (mIL)-2 genes resulted in substantial hepatic tumor regression, induced an effective systemic antitumoral immunity in the host and prolonged the median survival time of the treated animals from 22 to 35 days. The antitumoral immunity declined gradually, which led to tumor recurrence over time. A recombinant adenovirus expressing the mIL-12 gene was constructed and tested in the MCA-26 tumor model. Intratumoral administration of this cytokine vector alone increased significantly survival time of the animals with 25% of the treated animals still living over 70 days. These data indicate that local expression of IL-12 may also be an attractive treatment strategy for metastatic colon carcinoma.en_HK
dc.format.extent384 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsNational Academy of Sciences Proceedings. Copyright © National Academy of Sciences.en_HK
dc.subjectGene transferen_HK
dc.subjectCytokinesen_HK
dc.subjectRecombinant adenoviral vectorsen_HK
dc.titleAdenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-8424&volume=93&issue=21&spage=11302&epage=11306&date=1996&atitle=Adenovirus-mediated+interleukin-12+gene+therapy+for+metastatic+colon+carcinomaen_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1073/pnas.93.21.11302en_HK
dc.identifier.pmid8876130-
dc.identifier.pmcidPMC38052en_HK
dc.identifier.scopuseid_2-s2.0-0029859405en_HK
dc.identifier.hkuros24179-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029859405&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.isiWOS:A1996VM68100004-
dc.identifier.scopusauthoridCaruso, M=7102215432en_HK
dc.identifier.scopusauthoridPhamNguyen, K=6508030969en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridXu, B=7404589214en_HK
dc.identifier.scopusauthoridKosai, KI=35463991100en_HK
dc.identifier.scopusauthoridFinegold, M=7006478991en_HK
dc.identifier.scopusauthoridWoo, SLC=7402853378en_HK
dc.identifier.scopusauthoridChen, SH=7410253435en_HK

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