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Article: Hepatic events after bone marrow transplantation in patients with hepatitis B infection: A case controlled study

TitleHepatic events after bone marrow transplantation in patients with hepatitis B infection: A case controlled study
Authors
KeywordsBone marrow transplantation
GVHD
HBV
HBV reactivation
Hepatitis
VOD
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 1997, v. 19 n. 8, p. 795-799 How to Cite?
AbstractHepatitis B reactivation following chemotherapy withdrawal may result in hepatitis, hepatic failure and death. We studied the clinical outcome and the causes of hepatic events of hepatitis B surface antigen positive recipients undergoing bone marrow transplantation. Twenty-four hepatitis B surface antigen patients were matched with 24 hepatitis B surface antigen negative patients for age, sex, CMV positive serology, underlying hematological disease and type of bone marrow transplantation. Post-BMT, there were 18 patients in the hepatitis B surface antigen positive group and four patients in the hepatitis B surface antigen negative group who suffered from hepatitis (P < 0.05). Thirteen of the 18 hepatitis were related to HBV reactivation in the hepatitis B surface antigen positive group and none of the four hepatitis in the hepatitis B surface antigen negative group (P = 0.01). The hepatitis B surface antigen positive group also had an increased incidence of acute graft-versus-host disease of liver (6 vs 1, P = 0.03). However, there was no significant increase in the incidence of veno-occlusive disease (10 vs 7, P = 0.40) and persistent hepatitis (3 vs 0, P = 0.07) in the hepatitis B surface antigen positive group. Using the log-rank test, there was no significant difference in survival between the hepatitis B surface antigen positive and negative recipients.
Persistent Identifierhttp://hdl.handle.net/10722/49058
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorChiu, EKWen_HK
dc.contributor.authorLee, CKen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2008-06-12T06:33:30Z-
dc.date.available2008-06-12T06:33:30Z-
dc.date.issued1997en_HK
dc.identifier.citationBone Marrow Transplantation, 1997, v. 19 n. 8, p. 795-799en_HK
dc.identifier.issn0268-3369en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49058-
dc.description.abstractHepatitis B reactivation following chemotherapy withdrawal may result in hepatitis, hepatic failure and death. We studied the clinical outcome and the causes of hepatic events of hepatitis B surface antigen positive recipients undergoing bone marrow transplantation. Twenty-four hepatitis B surface antigen patients were matched with 24 hepatitis B surface antigen negative patients for age, sex, CMV positive serology, underlying hematological disease and type of bone marrow transplantation. Post-BMT, there were 18 patients in the hepatitis B surface antigen positive group and four patients in the hepatitis B surface antigen negative group who suffered from hepatitis (P < 0.05). Thirteen of the 18 hepatitis were related to HBV reactivation in the hepatitis B surface antigen positive group and none of the four hepatitis in the hepatitis B surface antigen negative group (P = 0.01). The hepatitis B surface antigen positive group also had an increased incidence of acute graft-versus-host disease of liver (6 vs 1, P = 0.03). However, there was no significant increase in the incidence of veno-occlusive disease (10 vs 7, P = 0.40) and persistent hepatitis (3 vs 0, P = 0.07) in the hepatitis B surface antigen positive group. Using the log-rank test, there was no significant difference in survival between the hepatitis B surface antigen positive and negative recipients.en_HK
dc.format.extent420 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_HK
dc.relation.ispartofBone Marrow Transplantationen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBone marrow transplantationen_HK
dc.subjectGVHDen_HK
dc.subjectHBVen_HK
dc.subjectHBV reactivationen_HK
dc.subjectHepatitisen_HK
dc.subjectVODen_HK
dc.titleHepatic events after bone marrow transplantation in patients with hepatitis B infection: A case controlled studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-3369&volume=19&issue=8&spage=795&epage=799&date=1997&atitle=Hepatic+events+after+bone+marrow+transplantation+in+patients+with+hepatitis+B+infection:+a+case+controlled+studyen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1038/sj.bmt.1700744en_HK
dc.identifier.pmid9134171-
dc.identifier.scopuseid_2-s2.0-0030983343en_HK
dc.identifier.hkuros22846-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030983343&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue8en_HK
dc.identifier.spage795en_HK
dc.identifier.epage799en_HK
dc.identifier.isiWOS:A1997WV98600007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridChiu, EKW=24827833600en_HK
dc.identifier.scopusauthoridLee, CK=36882460100en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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