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Article: Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

TitleNrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
Authors
Issue Date2002
PublisherAmerican Society for Microbiology.
Citation
Molecular And Cellular Biology, 2002, v. 22 n. 15, p. 5492-5505 How to Cite?
AbstractKeratinocyte growth factor (KGF) is a potent mitogen for epithelial cells, and it promotes survival of these cells under stress conditions. In a search for KGF-regulated genes in keratinocytes, we identified the gene encoding the transcription factor NF-E2-related factor 2 (Nrf2). Nrf2 is a key player in the cellular stress response. This might be of particular importance during wound healing, where large amounts of reactive oxygen species are produced as a defense against invading bacteria. Therefore, we studied the wound repair process in Nrf2 knockout mice. Interestingly, the expression of various key players involved in wound healing was significantly reduced in early wounds of the Nrf2 knockout animals, and the late phase of repair was characterized by prolonged inflammation. However, these differences in gene expression were not reflected by obvious histological abnormalities. The normal healing rate appears to be at least partially due to an up-regulation of the related transcription factor Nrf3, which was also identified as a target of KGF and which was coexpressed with Nrf2 in the healing skin wound. Taken together, our results reveal novel roles of the KGF-regulated transcription factors Nrf2 and possibly Nrf3 in the control of gene expression and inflammation during cutaneous wound repair.
Persistent Identifierhttp://hdl.handle.net/10722/49048
ISSN
2015 Impact Factor: 4.427
2015 SCImago Journal Rankings: 3.806
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBraun, Sen_HK
dc.contributor.authorHanselmann, Cen_HK
dc.contributor.authorGassmann, MGen_HK
dc.contributor.authorAuf dem Keller, UAen_HK
dc.contributor.authorBornBerclaz, Cen_HK
dc.contributor.authorChan, Ken_HK
dc.contributor.authorKan, YWen_HK
dc.contributor.authorWerner, Sen_HK
dc.date.accessioned2008-06-12T06:33:17Z-
dc.date.available2008-06-12T06:33:17Z-
dc.date.issued2002en_HK
dc.identifier.citationMolecular And Cellular Biology, 2002, v. 22 n. 15, p. 5492-5505en_HK
dc.identifier.issn0270-7306en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49048-
dc.description.abstractKeratinocyte growth factor (KGF) is a potent mitogen for epithelial cells, and it promotes survival of these cells under stress conditions. In a search for KGF-regulated genes in keratinocytes, we identified the gene encoding the transcription factor NF-E2-related factor 2 (Nrf2). Nrf2 is a key player in the cellular stress response. This might be of particular importance during wound healing, where large amounts of reactive oxygen species are produced as a defense against invading bacteria. Therefore, we studied the wound repair process in Nrf2 knockout mice. Interestingly, the expression of various key players involved in wound healing was significantly reduced in early wounds of the Nrf2 knockout animals, and the late phase of repair was characterized by prolonged inflammation. However, these differences in gene expression were not reflected by obvious histological abnormalities. The normal healing rate appears to be at least partially due to an up-regulation of the related transcription factor Nrf3, which was also identified as a target of KGF and which was coexpressed with Nrf2 in the healing skin wound. Taken together, our results reveal novel roles of the KGF-regulated transcription factors Nrf2 and possibly Nrf3 in the control of gene expression and inflammation during cutaneous wound repair.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofMolecular and Cellular Biologyen_HK
dc.rightsMolecular and Cellular Biology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Molecular and Cellular Biology, 2002, v. 22 n. 15, p. 5492-5505en_HK
dc.subject.meshDNA-Binding Proteins - deficiency - genetics - metabolismen_HK
dc.subject.meshFibroblast Growth Factors - pharmacologyen_HK
dc.subject.meshInflammation - metabolism - pathologyen_HK
dc.subject.meshKeratinocytes - drug effects - metabolism - pathologyen_HK
dc.subject.meshSkin - drug effects - injuries - pathologyen_HK
dc.titleNrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wounden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-7306&volume=22&issue=15&spage=5492&epage=5505&date=2002&atitle=Nrf2+transcription+factor,+a+novel+target+of+keratinocyte+growth+factor+action+which+regulates+gene+expression+and+inflammation+in+the+healing+skin+wounden_HK
dc.identifier.emailChan, K: kaimin@hkucc.hku.hken_HK
dc.identifier.authorityChan, K=rp00489en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/MCB.22.15.5492-5505.2002en_HK
dc.identifier.pmid12101242-
dc.identifier.pmcidPMC133949en_HK
dc.identifier.scopuseid_2-s2.0-0036318224en_HK
dc.identifier.hkuros113817-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036318224&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue15en_HK
dc.identifier.spage5492en_HK
dc.identifier.epage5505en_HK
dc.identifier.isiWOS:000176743600020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridBraun, S=7201804637en_HK
dc.identifier.scopusauthoridHanselmann, C=6506204434en_HK
dc.identifier.scopusauthoridGassmann, MG=12797420700en_HK
dc.identifier.scopusauthoridAuf dem Keller, UA=6506489394en_HK
dc.identifier.scopusauthoridBornBerclaz, C=6505644186en_HK
dc.identifier.scopusauthoridChan, K=7406032228en_HK
dc.identifier.scopusauthoridKan, YW=36919857000en_HK
dc.identifier.scopusauthoridWerner, S=7202885883en_HK

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