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- Publisher Website: 10.1073/pnas.0408487101
- Scopus: eid_2-s2.0-11844253848
- PMID: 15611470
- WOS: WOS:000226216400044
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Article: Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription
Title | Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription |
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Authors | |
Keywords | 3-Nitropropionic acid Antioxidant response element Astrocytes malonate |
Issue Date | 2005 |
Publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2005, v. 102 n. 1, p. 244-249 How to Cite? |
Abstract | Complex II inhibitors 3-nitropropionic acid (3NP) and malonate cause striatal damage reminiscent of Huntington's disease and have been shown to involve oxidative stress in their pathogenesis. Because nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent transcriptional activation by means of the antioxidant response element is known to coordinate the up-regulation of cytoprotective genes involved in combating oxidative stress, we investigated the significance of Nrf2 in complex II-induced toxicity. We found that Nrf2-deficient cells and Nrf2 knockout mice are significantly more vulnerable to malonate and 3NP and demonstrate increased antioxidant response element (ARE)-regulated transcription mediated by astrocytes. Furthermore, ARE preactivation by means of intrastriatal transplantation of Nrf2-overexpressing astrocytes before lesioning conferred dramatic protection against complex II inhibition. These observations implicate Nrf2 as an essential inducible factor in the protection against complex II inhibitor-mediated neurotoxicity. These data also introduce Nrf2-mediated ARE transcription as a potential target of preventative therapy in neurodegenerative disorders such as Huntington's disease. |
Persistent Identifier | http://hdl.handle.net/10722/49046 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
PubMed Central ID | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Calkins, MJ | en_HK |
dc.contributor.author | Jakel, RJ | en_HK |
dc.contributor.author | Johnson, DA | en_HK |
dc.contributor.author | Chan, K | en_HK |
dc.contributor.author | Yuen, WK | en_HK |
dc.contributor.author | Johnson, JA | en_HK |
dc.date.accessioned | 2008-06-12T06:33:14Z | - |
dc.date.available | 2008-06-12T06:33:14Z | - |
dc.date.issued | 2005 | en_HK |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2005, v. 102 n. 1, p. 244-249 | en_HK |
dc.identifier.issn | 0027-8424 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/49046 | - |
dc.description.abstract | Complex II inhibitors 3-nitropropionic acid (3NP) and malonate cause striatal damage reminiscent of Huntington's disease and have been shown to involve oxidative stress in their pathogenesis. Because nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent transcriptional activation by means of the antioxidant response element is known to coordinate the up-regulation of cytoprotective genes involved in combating oxidative stress, we investigated the significance of Nrf2 in complex II-induced toxicity. We found that Nrf2-deficient cells and Nrf2 knockout mice are significantly more vulnerable to malonate and 3NP and demonstrate increased antioxidant response element (ARE)-regulated transcription mediated by astrocytes. Furthermore, ARE preactivation by means of intrastriatal transplantation of Nrf2-overexpressing astrocytes before lesioning conferred dramatic protection against complex II inhibition. These observations implicate Nrf2 as an essential inducible factor in the protection against complex II inhibitor-mediated neurotoxicity. These data also introduce Nrf2-mediated ARE transcription as a potential target of preventative therapy in neurodegenerative disorders such as Huntington's disease. | en_HK |
dc.format.extent | 386 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | eng | en_HK |
dc.publisher | National Academy of Sciences. The Journal's web site is located at http://www.pnas.org | en_HK |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | en_HK |
dc.subject | 3-Nitropropionic acid | en_HK |
dc.subject | Antioxidant response element | en_HK |
dc.subject | Astrocytes malonate | en_HK |
dc.title | Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chan, K: kaimin@hkucc.hku.hk | en_HK |
dc.identifier.authority | Chan, K=rp00489 | en_HK |
dc.description.nature | link_to_OA_fulltext | en_HK |
dc.identifier.doi | 10.1073/pnas.0408487101 | en_HK |
dc.identifier.pmid | 15611470 | - |
dc.identifier.pmcid | PMC538748 | en_HK |
dc.identifier.scopus | eid_2-s2.0-11844253848 | en_HK |
dc.identifier.hkuros | 113813 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-11844253848&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 102 | en_HK |
dc.identifier.issue | 1 | en_HK |
dc.identifier.spage | 244 | en_HK |
dc.identifier.epage | 249 | en_HK |
dc.identifier.isi | WOS:000226216400044 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Calkins, MJ=7007180294 | en_HK |
dc.identifier.scopusauthorid | Jakel, RJ=6602508857 | en_HK |
dc.identifier.scopusauthorid | Johnson, DA=7406822641 | en_HK |
dc.identifier.scopusauthorid | Chan, K=7406032228 | en_HK |
dc.identifier.scopusauthorid | Yuen, WK=7102761279 | en_HK |
dc.identifier.scopusauthorid | Johnson, JA=7406813149 | en_HK |
dc.identifier.issnl | 0027-8424 | - |